2022
Returning to basic principles to develop more effective treatments for central nervous system disorders
Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology And Medicine 2022, 247: 856-867. PMID: 35172621, PMCID: PMC9158240, DOI: 10.1177/15353702221078291.Peer-Reviewed Original ResearchConceptsCentral nervous systemPositron emission tomographyNeuroplastic processesMagnetic stimulationCentral nervous system disordersFunctional magnetic resonance imaging (fMRI) imagingNervous system disordersMagnetic resonance imaging (MRI) imagingSystem-based initiativesCNS diseasesClinical trialsEffective treatmentSystem disordersSide effectsNervous systemNew treatmentsClinical disordersCandidate drugsEmission tomographyBrain functionPreclinical research
1991
Failure at task-specific regional brain activation: new conceptualization of a disease entity
Wexler B. Failure at task-specific regional brain activation: new conceptualization of a disease entity. Journal Of Neuropsychiatry 1991, 3: 94-98. PMID: 7580183, DOI: 10.1176/jnp.3.1.94.Peer-Reviewed Original ResearchConceptsNormal brain functionSymptom-based diagnosisRegional brain activationBrain functionBrain activationGroup of patientsCurrent symptom-based diagnosesMultiple brain regionsSpecific anatomic locationsClinical courseEtiologic diagnosisDisease entityAnatomic locationClinical practiceCurrent diagnostic systemsNew treatmentsPathophysiological processesBrain regionsDSM-IIIOrgan systemsDiagnosisBranches of medicinePhysiological dysfunctionNormal functionPatients