2023
Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function
Wexler B, Kish R. Using micro-cognition biomarkers of neurosystem dysfunction to redefine ADHD subtypes: A scalable digital path to diagnosis based on brain function. Psychiatry Research 2023, 326: 115348. PMID: 37494880, PMCID: PMC10517859, DOI: 10.1016/j.psychres.2023.115348.Peer-Reviewed Original ResearchConceptsPoor response inhibitionResponse inhibitionSymptom-based diagnosisGO/NOGO testMarked performance decrementsNew treatment developmentTD childrenADHD childrenADHD subtypesPerformance decrementsInconsistent attentionAbstract categoriesTreatment developmentNatural categoriesBrain functionADHDDifferent neuropathologiesChildren 6Individual patientsTreatment selection
2022
Returning to basic principles to develop more effective treatments for central nervous system disorders
Wexler BE. Returning to basic principles to develop more effective treatments for central nervous system disorders. Experimental Biology And Medicine 2022, 247: 856-867. PMID: 35172621, PMCID: PMC9158240, DOI: 10.1177/15353702221078291.Peer-Reviewed Original ResearchConceptsCentral nervous systemPositron emission tomographyNeuroplastic processesMagnetic stimulationCentral nervous system disordersFunctional magnetic resonance imaging (fMRI) imagingNervous system disordersMagnetic resonance imaging (MRI) imagingSystem-based initiativesCNS diseasesClinical trialsEffective treatmentSystem disordersSide effectsNervous systemNew treatmentsClinical disordersCandidate drugsEmission tomographyBrain functionPreclinical research
2010
Neuroplasticity: Biological Evolution’s Contribution to Cultural Evolution
Wexler B. Neuroplasticity: Biological Evolution’s Contribution to Cultural Evolution. On Thinking 2010, 1-17. DOI: 10.1007/978-3-642-15423-2_1.Peer-Reviewed Original ResearchNeuronal activityBrain areasNeuronal connectionsBrain shapingMost childrenBrain functionBrain structuresYoung adulthoodDifferent neural structuresNumber of cellsNeural structuresOnly animalsNeurocognitive structuresTransgenerational alterationsChildhoodAdulthoodBrain sizeCellsHumansAnimalsFunctional systems
2004
Using fMRI to Study the Mind and Brain
Wexler B. Using fMRI to Study the Mind and Brain. 2004, 279-293. DOI: 10.1002/0470020520.ch15.Chapters
1991
Failure at task-specific regional brain activation: new conceptualization of a disease entity
Wexler B. Failure at task-specific regional brain activation: new conceptualization of a disease entity. Journal Of Neuropsychiatry 1991, 3: 94-98. PMID: 7580183, DOI: 10.1176/jnp.3.1.94.Peer-Reviewed Original ResearchConceptsNormal brain functionSymptom-based diagnosisRegional brain activationBrain functionBrain activationGroup of patientsCurrent symptom-based diagnosesMultiple brain regionsSpecific anatomic locationsClinical courseEtiologic diagnosisDisease entityAnatomic locationClinical practiceCurrent diagnostic systemsNew treatmentsPathophysiological processesBrain regionsDSM-IIIOrgan systemsDiagnosisBranches of medicinePhysiological dysfunctionNormal functionPatients
1986
A Model of Brain Function: Its Implications for Psychiatric Research
Wexler B. A Model of Brain Function: Its Implications for Psychiatric Research. The British Journal Of Psychiatry 1986, 148: 357-362. PMID: 3730703, DOI: 10.1192/bjp.148.4.357.Peer-Reviewed Original Research