2015
Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender
Bolling DZ, Pelphrey KA, Vander Wyk B. Unlike adults, children and adolescents show predominantly increased neural activation to social exclusion by members of the opposite gender. Social Neuroscience 2015, 11: 475-486. PMID: 26592311, PMCID: PMC4976300, DOI: 10.1080/17470919.2015.1117019.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingNeural correlatesGroup membershipOnline ball-tossing gameSocial exclusionAnterior cingulate responsesBall-tossing gameSocial anxiety disorderOpposite genderSocio-emotional developmentDifferential neural correlatesAnterior cingulate cortexPrevious adult studiesPeer rejectionCingulate responseBrain responsesPeer relationsNeural activationAnxiety disordersCingulate cortexMain effectCurrent studyAdolescenceIncreased activationAdolescentsTrait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders
Bolling DZ, Pelphrey KA, Wyk B. Trait-level temporal lobe hypoactivation to social exclusion in unaffected siblings of children and adolescents with autism spectrum disorders. Developmental Cognitive Neuroscience 2015, 13: 75-83. PMID: 26011751, PMCID: PMC4470300, DOI: 10.1016/j.dcn.2015.04.007.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderPosterior superior temporal sulcusUnaffected siblingsAtypical neural processingSocial exclusionFunctional magnetic resonance imagingSuperior temporal sulcusAbnormal neural responsesAnterior temporoparietal junctionAnterior cingulate cortexEmotion processingTemporoparietal junctionNegative affectTemporal sulcusNeural processingBrain responsesNeural endophenotypesNeural responsesNeural activationCingulate cortexNeural circuitrySocial experienceASD probandsPowerful feelings
2014
Altered brain connectivity in sagittal craniosynostosis.
Beckett JS, Brooks ED, Lacadie C, Wyk B, Jou RJ, Steinbacher DM, Constable RT, Pelphrey KA, Persing JA. Altered brain connectivity in sagittal craniosynostosis. Journal Of Neurosurgery Pediatrics 2014, 13: 690-8. PMID: 24745341, DOI: 10.3171/2014.3.peds13516.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingPosterior cingulate cortexCingulate cortexSagittal nonsyndromic craniosynostosisPrefrontal cortexRight posterior cingulate cortexBrodmann area 8Functional connectivity differencesRight middle frontal gyrusWhite matter alterationsAnterior cingulate cortexBrodmann area 7Left ventromedial prefrontal cortexAltered brain connectivityResting-state functional connectivity MRI dataMiddle frontal gyrusRight supramarginal gyrusDefault mode networkIntrinsic connectivity analysesSignificant group differencesAdolescent patientsAltered connectivityNeurocognitive morbidityHigh prevalenceRight parahippocampus
2011
Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differences