2024
Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchMeSH KeywordsAdultChildChild HealthCohort StudiesCross-Sectional StudiesEnvironmental ExposureEnvironmental PollutantsFemaleFluorocarbonsHumansLipidsMaternal ExposurePregnancyConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposureAssociations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchMeSH KeywordsAdultEicosanoidsEnvironmental PollutantsFemaleHumansMaternal ExposureMetalsMetals, HeavyPregnancyPuerto RicoYoung AdultConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory response
2023
Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort
Goutman S, Boss J, Jang D, Mukherjee B, Richardson R, Batterman S, Feldman E. Environmental risk scores of persistent organic pollutants associate with higher ALS risk and shorter survival in a new Michigan case/control cohort. Journal Of Neurology Neurosurgery & Psychiatry 2023, 95: 241-248. PMID: 37758454, PMCID: PMC11060633, DOI: 10.1136/jnnp-2023-332121.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisEnvironmental PollutantsHumansHydrocarbons, ChlorinatedMichiganPersistent Organic PollutantsRisk FactorsConceptsEnvironmental risk scoreAmyotrophic lateral sclerosis riskPersistent organic pollutantsALS riskInterquartile increaseHigher ALS riskAssociated with ALS riskModify disease riskOrganochlorine pesticidesAssociated with riskRisk reduction strategiesPersistent organic pollutant analysisIndividual persistent organic pollutantsPersistent organic pollutant mixturesHazard ratioDisease riskRisk scoreCase/control cohortEnvironmental exposuresControl participantsGenetic susceptibilityPolychlorinated biphenylsAlpha-hexachlorocyclohexaneOrganic pollutantsMortality ratePrenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008
Siwakoti R, Cathey A, Ferguson K, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006–2008. Environmental Research 2023, 237: 116967. PMID: 37634691, PMCID: PMC10913455, DOI: 10.1016/j.envres.2023.116967.Peer-Reviewed Original ResearchConceptsLarge-for-gestational agePreterm birth subtypesBayesian kernel machine regressionSize-for-gestational ageSmall-for-gestational agePreterm birthFetal sexPregnancy outcomesSex-specific estimatesIncreased risk of adverse pregnancy outcomesInterquartile range increaseRisk of adverse pregnancy outcomesBayesian kernel machine regression analysisEarly pregnancy samplesAdverse pregnancy outcomesCase-control studyPrenatal PFAS exposureAssociations of polyfluoroalkyl substancesBW z-scoreEffects of polyfluoroalkyl substancesKernel machine regressionEffect modificationEffects of prenatal exposureRange increaseStratified analysisPer- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation
Kang H, Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Park S. Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45–56 Years of Age: The Study of Women’s Health Across the Nation. Environmental Health Perspectives 2023, 131: 087004. PMID: 37552133, PMCID: PMC10408595, DOI: 10.1289/ehp12351.Peer-Reviewed Original ResearchMeSH KeywordsAlkanesulfonic AcidsCholesterolCholesterol, LDLEnvironmental PollutantsFemaleFluorocarbonsHumansLipidsTriglyceridesWomen's HealthConceptsStudy of Women's HealthOdds ratioWomen's HealthMidlife womenConfidence intervalsFavorable blood lipid profileEstimate odds ratiosAdverse effects of PFASSerum PFAS concentrationsLatent class growth modelingLongitudinal trajectoriesAssociated with totalMenopausal transitionAssociated with trajectoriesLow-density lipoprotein (LDL) cholesterolHigh-density lipoprotein (HDL) cholesterolLipid trajectoriesAverage follow-upBlood total cholesterolBlood lipid profileTriglycerides trajectoriesEpidemiological studiesPositive associationBlood lipidsLDL cholesterolPhthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental ExposureEnvironmental PollutantsFemaleHumansPhthalic AcidsWomen's HealthConceptsStudy of Women's HealthIncidence of diabetesWomen's HealthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidence
2022
Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey
Roberts E, Boss J, Mukherjee B, Salerno S, Zota A, Needham B. Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey. Scientific Reports 2022, 12: 19960. PMID: 36402910, PMCID: PMC9675834, DOI: 10.1038/s41598-022-24316-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Sectional StudiesEnvironmental PollutantsHumansLeukocytesNutrition SurveysPersistent Organic PollutantsPolychlorinated BiphenylsTelomereWhite PeopleConceptsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyPersistent organic pollutantsLeukocyte telomere lengthNutrition Examination SurveyToxic equivalent quotientPolychlorinated biphenylsBlack/white differencesExamination SurveyCross-sectional National Health and Nutrition Examination SurveyNon-Hispanic Black AmericansExposure scoreNon-Hispanic white AmericansSurvey-weighted linear regression modelsIndirect effects of raceAssociated with longer leukocyte telomere lengthSingle-pollutant modelsIndividual persistent organic pollutantsExposure to polychlorinated biphenylsLonger leukocyte telomere lengthSelf-reported racePersistent organic pollutant exposuresBlack AmericansIndividual polychlorinated biphenylOrganic pollutant exposuresPhthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalate exposure is associated with more rapid body fat gain in midlife women: The Study of Women's Health Across the Nation (SWAN) Multi-Pollutant Study. Environmental Research 2022, 216: 114685. PMID: 36341787, PMCID: PMC9870605, DOI: 10.1016/j.envres.2022.114685.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueEnvironmental ExposureEnvironmental PollutantsFemaleHumansObesityPhthalic AcidsThinnessWomen's HealthConceptsDual-energy X-ray absorptiometryBody fat gainStudy of Women's HealthBaseline obesity statusFat massFat gainObesity statusPhthalate metabolitesMidlife womenPhthalate exposureWomen's HealthX-ray absorptiometryEtiology of obesityMono-carboxy-isononyl phthalateAttenuation of estimatesBody fat percentageBody weightMono-isobutyl phthalateMono(3-carboxypropyl) phthalateNormal/underweight womenAssociated with faster increasesMenopause-related factorsStudy obesityStratified analysisFM changesPer- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation
Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Harlow S, Park S. Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation. Hypertension 2022, 79: 1876-1886. PMID: 35695012, PMCID: PMC9308661, DOI: 10.1161/hypertensionaha.121.18809.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEnvironmental PollutantsFemaleFluorocarbonsHumansHypertensionWomen's HealthConceptsHazard ratioIncident hypertensionLowest tertileHighest tertileStudy of Women's HealthFree of hypertensionCalculate hazard ratiosAnnual follow-up visitsCardiovascular disease riskCox proportional hazards modelsQuantile g-computationWomen's cardiovascular disease riskWomen's HealthNo significant associationProportional hazards modelMidlife womenFollow-up visitG-computationDisease riskBlood pressure controlSerum concentrationsSignificant associationPositive associationHazards modelTertilePer- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusEnvironmental PollutantsFemaleFluorocarbonsGlucoseHumansProspective StudiesWomen's HealthConceptsStudy of Women's HealthIncident diabetesWomen's HealthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort studyBiomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersBirth CohortBirth WeightEnvironmental PollutantsFemaleHumansInfant, NewbornMalePhthalic AcidsPregnancyPremature BirthPuerto RicoConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortPerfluoroalkyl Substances and Incident Natural Menopause in Midlife Women: The Mediating Role of Sex Hormones
Ding N, Harlow S, Randolph J, Mukherjee B, Batterman S, Gold E, Park S. Perfluoroalkyl Substances and Incident Natural Menopause in Midlife Women: The Mediating Role of Sex Hormones. American Journal Of Epidemiology 2022, 191: 1212-1223. PMID: 35292812, PMCID: PMC9393069, DOI: 10.1093/aje/kwac052.Peer-Reviewed Original ResearchMeSH KeywordsAlkanesulfonic AcidsEnvironmental PollutantsEstradiolFemaleFluorocarbonsFollicle Stimulating HormoneGonadal Steroid HormonesHumansMenopauseMaternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico
Ashrap P, Aung M, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal urinary phthalate metabolites are associated with lipidomic signatures among pregnant women in Puerto Rico. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 384-391. PMID: 35075242, PMCID: PMC9124693, DOI: 10.1038/s41370-022-00410-3.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersDiglyceridesEnvironmental PollutantsFemaleHumansLipidomicsPhosphatidylcholinesPhthalic AcidsPregnancyPregnant WomenPuerto RicoConceptsUrinary phthalate metabolitesPhthalate metabolitesPlasmenyl-phosphatidylcholinesPregnant womenPuerto Rico PROTECT cohortPhthalate exposureLipidomic profilesMaternal urinary phthalate metabolitesWeeks of pregnancyMetabolite biomarkersMetabolites of di-2-ethylhexyl phthalateChild health outcomesCirculating lipid concentrationsLipidomic markersShotgun lipidomicsFatty acid chainsLipidomic signaturePROTECT cohortLipid profileCell-to-cell signalingImpactThis studyPregnancyAcid chainsPlasma samplesHealth outcomesMediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental PollutantsFemaleGestational AgeHormonesHumansInfant, NewbornMalePhthalic AcidsPregnancyPremature BirthConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women’s Health Across the Nation. Environment International 2021, 157: 106781. PMID: 34311223, PMCID: PMC8490279, DOI: 10.1016/j.envint.2021.106781.Peer-Reviewed Original ResearchConceptsMetal mixturesMetal concentrationsTiming of natural menopauseCox proportional hazards modelsNatural menopauseStudy of Women's HealthProportional hazards modelHazard ratioEnvironmental risk scoreLowest quartileIndividual metal concentrationsExposure to metalsUrinary metal concentrationsHazards modelMedian follow-upMonths of amenorrheaWomen's HealthAssociated with earlier natural menopauseEarly natural menopauseUrinary metalsNation Multi-Pollutant StudyBleeding episodesHormone therapyPremenopausal womenMedian ageAssociations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women. International Journal Of Hygiene And Environmental Health 2021, 235: 113777. PMID: 34090141, PMCID: PMC8207532, DOI: 10.1016/j.ijheh.2021.113777.Peer-Reviewed Original ResearchMeSH KeywordsAdipokinesAlkanesulfonic AcidsBayes TheoremEnvironmental PollutantsFemaleFluorocarbonsHumansWomen's HealthConceptsBayesian kernel machine regressionNormal weightStudy of Women's HealthCirculating levels of leptinHMW adiponectinBayesian kernel machine regression analysisSoluble leptin receptorFree leptin indexSOB-R concentrationsBaseline serum samplesLevels of leptinMultivariate linear regressionPhysical activityAssociated with obesityStatistically significant associationWomen's HealthPolyfluoroalkyl substancesWaist circumferenceKernel machine regressionWomen's backgroundInfluence obesityMidlife womenSmoking statusSOB-RMenopausal statusCross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches. Environmental Health Perspectives 2021, 129: 037007. PMID: 33761273, PMCID: PMC7990518, DOI: 10.1289/ehp7396.Peer-Reviewed Original ResearchMeSH KeywordsBayes TheoremBiomarkersCross-Sectional StudiesEnvironmental PollutantsFemaleHumansPhenolsPhthalic AcidsPolycyclic Aromatic HydrocarbonsPregnancyConceptsExposure analytesToxicity classesMixtures of toxicantsSingle-pollutant modelsPolycyclic aromatic hydrocarbonsHierarchical Bayesian kernel machine regressionBayesian kernel machine regressionKernel machine regressionPrenatal toxicant exposureAdaptive elastic net regressionClasses of toxicantsSingle-pollutantTrace metalsAromatic hydrocarbonsToxic mixturePair-wise associationsAdaptive elastic netToxicant exposurePhthalateMachine regressionEndogenous biomarkersBiomarkers indicativeMultiple linear regressionMetalToxicity
2020
Application of an analytical framework for multivariate mediation analysis of environmental data
Aung M, Song Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Meeker J, Mukherjee B. Application of an analytical framework for multivariate mediation analysis of environmental data. Nature Communications 2020, 11: 5624. PMID: 33159049, PMCID: PMC7648785, DOI: 10.1038/s41467-020-19335-2.Peer-Reviewed Original ResearchAssociations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation
Ding N, Harlow S, Randolph J, Calafat A, Mukherjee B, Batterman S, Gold E, Park S. Associations of Perfluoroalkyl Substances with Incident Natural Menopause: The Study of Women’s Health Across the Nation. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa303. PMID: 32491182, PMCID: PMC7418447, DOI: 10.1210/clinem/dgaa303.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthNatural menopauseHazard ratioSerum concentrationsWomen's HealthCohort of midlife womenConfidence intervalsCalculate hazard ratiosAdverse health outcomesPFAS serum concentrationsMonths of amenorrheaAssociation of perfluoroalkyl substancesEarly natural menopauseBaseline serum concentrationsCox proportional hazards modelsAssociated with earlier natural menopauseIsotope dilution tandem mass spectrometryHealth outcomesProportional hazards modelReverse causationBleeding episodesMidlife womenLowest tertileMedian timeHormone use
2019
Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals
Aung M, Meeker J, Boss J, Bakulski K, Mukherjee B, Cantonwine D, McElrath T, Ferguson K. Manganese is associated with increased plasma interleukin-1β during pregnancy, within a mixtures analysis framework of urinary trace metals. Reproductive Toxicology 2019, 93: 43-53. PMID: 31881266, PMCID: PMC7138746, DOI: 10.1016/j.reprotox.2019.12.004.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiological MonitoringBiomarkersEnvironmental PollutantsFemaleFetusHumansInterleukin-1betaMaleMetalsPregnancyYoung AdultConceptsIL-1BBayesian kernel machine regressionKernel machine regressionInterleukin-1bInterquartile range differenceCross-sectional studyAssociated with biomarkersReproductive health outcomesImmune signaling moleculesHealth outcomesLIFECODES birth cohortPregnant womenImmune perturbationsImmune biomarkersBirth cohortUrinary manganeseMachine regressionLinear regressionExposure analytesAssociationSignaling moleculesRegressionPair-wise associationsTrimesterPregnancy