2022
Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation
Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Harlow S, Park S. Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation. Hypertension 2022, 79: 1876-1886. PMID: 35695012, PMCID: PMC9308661, DOI: 10.1161/hypertensionaha.121.18809.Peer-Reviewed Original ResearchMeSH KeywordsBlood PressureEnvironmental PollutantsFemaleFluorocarbonsHumansHypertensionWomen's HealthConceptsHazard ratioIncident hypertensionLowest tertileHighest tertileStudy of Women's HealthFree of hypertensionCalculate hazard ratiosAnnual follow-up visitsCardiovascular disease riskCox proportional hazards modelsQuantile g-computationWomen's cardiovascular disease riskWomen's HealthNo significant associationProportional hazards modelMidlife womenFollow-up visitG-computationDisease riskBlood pressure controlSerum concentrationsSignificant associationPositive associationHazards modelTertile
2021
Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation. Hypertension 2021, 78: 543-551. PMID: 34148361, PMCID: PMC8266752, DOI: 10.1161/hypertensionaha.121.17295.Peer-Reviewed Original Research
2017
Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA)
He Z, Lee S, Zhang M, Smith J, Guo X, Palmas W, Kardia S, Ionita‐Laza I, Mukherjee B. Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA). Genetic Epidemiology 2017, 41: 801-810. PMID: 29076270, PMCID: PMC5696115, DOI: 10.1002/gepi.22081.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisType I error rateRare-variant association testsRare variantsGene-based association testsRare-variant associationsAssociation TestLongitudinal outcomesLongitudinal studyExome sequencing dataMeasurement of blood pressureGenomic regionsSequence dataTrait heritabilitySequencing studiesMeasured outcomesGenetic variantsVariant analysisModerate sample sizesIndividual variantsRobust to misspecificationWithin-subject correlationStatistical powerExposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction
Sun Z, Mukherjee B, Estes J, Vokonas P, Park S. Exposure enriched outcome dependent designs for longitudinal studies of gene–environment interaction. Statistics In Medicine 2017, 36: 2947-2960. PMID: 28497531, PMCID: PMC5523112, DOI: 10.1002/sim.7332.Peer-Reviewed Original ResearchConceptsLongitudinal cohort studyCohort studyCase-only designLongitudinal studyG x E interactionNormative Aging StudyComplete-case analysisGene-environmentSampling designCase-controlVeterans AdministrationComplex human diseasesE interactionExposure informationAging StudyOutcome trajectoriesStratified samplingRetrospective genotypingIndividual exposureCovariate dataExposure effectsJoint effectsOutcomesTime-varying outcomeEnvironmental factors
2015
Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance
Brook R, Sun Z, Brook J, Zhao X, Ruan Y, Yan J, Mukherjee B, Rao X, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Sun Q, Fan Z, Rajagopalan S. Extreme Air Pollution Conditions Adversely Affect Blood Pressure and Insulin Resistance. Hypertension 2015, 67: 77-85. PMID: 26573709, PMCID: PMC4830086, DOI: 10.1161/hypertensionaha.115.06237.Peer-Reviewed Original ResearchConceptsFine particulate matterParticulate matterAmbient fine particulate matterSD increaseAssociated with worsening insulin resistanceBlack carbon levelsBlack carbon exposurePublic health warningsAir pollutionBeijing metropolitan areaBlack carbonHealth warningsAssociated with rangeCardiometabolic healthCarbon levelsDiastolic blood pressureExposure windowsCardiometabolic diseasesHealth effectsNonsmoking adultsMetabolic syndromeDeveloping world todayCarbon exposureSystolic blood pressure elevationHealth
2014
The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures
Morishita M, Bard R, Wang L, Das R, Dvonch J, Spino C, Mukherjee B, Sun Q, Harkema J, Rajagopalan S, Brook R. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal Of Exposure Science & Environmental Epidemiology 2014, 25: 153-159. PMID: 25227729, PMCID: PMC4462122, DOI: 10.1038/jes.2014.62.Peer-Reviewed Original ResearchConceptsCoarse PMPM massEffects of coarse PMCoarse PM massAmbient coarse PMRural locationsSystolic BPMetrics of exposureBlood pressurePotential health effectsHeart ratePM elementsElevated systolic BPFiltered airAerodynamic diameterDiastolic BP changesMixed model analysisConcentration-response mannerParticulate massFilter samplesParticle constituentsDiastolic BPMeasured elementsHealthy adultsAssociated with similar degreesHemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location
Brook R, Bard R, Morishita M, Dvonch J, Wang L, Yang H, Spino C, Mukherjee B, Kaplan M, Yalavarthi S, Oral E, Ajluni N, Sun Q, Brook J, Harkema J, Rajagopalan S. Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location. Environmental Health Perspectives 2014, 122: 624-630. PMID: 24618231, PMCID: PMC4050508, DOI: 10.1289/ehp.1306595.Peer-Reviewed Original ResearchConceptsCoarse PMParticulate matterAir pollutionRural locationsCoarse particlesParticulate matter air pollutionCoarse PM exposureAssociated with numerous adverse health effectsAcute CV eventsBlood pressureFine particulate matterAmbient coarse particlesNumerous adverse health effectsGlobal air pollutionAdverse health effectsHeart rateFrequency heart rate variabilityCoarse CAPPM exposureFiltered airRandomized double-blind crossover studyDiastolic BPDouble-blind crossover studyHealth effectsHealthy adultsPersonal Black Carbon Exposure Influences Ambulatory Blood Pressure
Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H, Zhang S, Fang Q, Gu D, Brook J, Sun Q, Brook R, Rajagopalan S, Fan Z. Personal Black Carbon Exposure Influences Ambulatory Blood Pressure. Hypertension 2014, 63: 871-877. PMID: 24420543, PMCID: PMC4445364, DOI: 10.1161/hypertensionaha.113.02588.Peer-Reviewed Original ResearchConceptsPersonal black carbonAir pollutionBlack carbonBeijing Municipal Environmental Monitoring CenterFine particulate matter concentrationsCombustion-related air pollutionFine particulate matterAmbulatory blood pressureEnvironmental Monitoring CenterParticulate matter concentrationsBlood pressureHigh air pollutionReduce air pollutionMm HgLow frequency to high frequency ratioPublic health effectsParticulate matterTwenty-four-hour ambulatory blood pressureExposure to high levelsMatter concentrationSystolic blood pressureDiastolic blood pressurePollutionBlood pressure effectsGeneralized linear model
2013
Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome
Wagner J, Allen K, Yang H, Nan B, Morishita M, Mukherjee B, Dvonch J, Spino C, Fink G, Rajagopalan S, Sun Q, Brook R, Harkema J. Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter and Ozone: Effects of Diet-Induced Metabolic Syndrome. Environmental Health Perspectives 2013, 122: 27-33. PMID: 24169565, PMCID: PMC3888573, DOI: 10.1289/ehp.1307085.Peer-Reviewed Original ResearchConceptsHFrD ratsBlood pressureND ratsHeart rateMetabolic syndromeHR variabilityFasting levels of blood glucoseNormal dietMale Sprague-Dawley ratsParticulate matterAssociated with cardiovascular morbidityCardiovascular depressionAir pollutionSprague-Dawley ratsDiet-induced metabolic syndromeElevated fasting levelsToxicity of air pollutantsFine particulate matterHigh-fructose dietLevels of blood glucoseInhalable particulate matterLevels of ozoneInduce MetSCardiovascular morbidityExaggerated BP
2012
Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes
Sun Z, Mukherjee B, Brook R, Gatts G, Yang F, Sun Q, Brook J, Fan Z, Rajagopalan S. Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study investigating the impact of air pollution exposure and propensity for type II diabetes. The Science Of The Total Environment 2012, 448: 72-78. PMID: 23182147, PMCID: PMC4548977, DOI: 10.1016/j.scitotenv.2012.10.087.Peer-Reviewed Original ResearchConceptsAir pollution exposureAir pollutionAmbient fine particulate matterMeasures of air pollution exposureImpact of air pollution exposureFine particulate matterExposure to PM2.5Air pollution measurementsPersonal exposure measurementsCreation of novel methodologiesSub-acute exposurePolluted urban environmentsImpact of environmental factorsParticulate matterPollution exposureStudy visitsPollution measurementsType II diabetesProspective cohort studyEnvironmental risk factorsAmbient measurementsII diabetesCohort studyUrban environmentScreening visit