2022
Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN)
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Park S. Race-specific associations of urinary phenols and parabens with adipokines in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 303: 119164. PMID: 35306088, PMCID: PMC9883839, DOI: 10.1016/j.envpol.2022.119164.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthBayesian kernel machine regressionWomen's HealthLeptin levelsBlack womenAssociated with lower leptinAssociated with favorable profilesAsian womenSoluble leptin receptorRacial differencesRace-specific associationsUrinary phenolCross-sectional associationsNo significant associationObesity-related metabolic diseasesLog-transformed levelsSOB-RKernel machine regressionSerum adipokinesMetabolic disease burdenEffect modificationNation Multi-Pollutant StudyLow leptinLeptin receptorLinear regression models
2021
Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Cross-Sectional Estimation of Endogenous Biomarker Associations with Prenatal Phenols, Phthalates, Metals, and Polycyclic Aromatic Hydrocarbons in Single-Pollutant and Mixtures Analysis Approaches. Environmental Health Perspectives 2021, 129: 037007. PMID: 33761273, PMCID: PMC7990518, DOI: 10.1289/ehp7396.Peer-Reviewed Original ResearchConceptsExposure analytesToxicity classesMixtures of toxicantsSingle-pollutant modelsPolycyclic aromatic hydrocarbonsHierarchical Bayesian kernel machine regressionBayesian kernel machine regressionKernel machine regressionPrenatal toxicant exposureAdaptive elastic net regressionClasses of toxicantsSingle-pollutantTrace metalsAromatic hydrocarbonsToxic mixturePair-wise associationsAdaptive elastic netToxicant exposurePhthalateMachine regressionEndogenous biomarkersBiomarkers indicativeMultiple linear regressionMetalToxicity
2020
Application of an analytical framework for multivariate mediation analysis of environmental data
Aung M, Song Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Meeker J, Mukherjee B. Application of an analytical framework for multivariate mediation analysis of environmental data. Nature Communications 2020, 11: 5624. PMID: 33159049, PMCID: PMC7648785, DOI: 10.1038/s41467-020-19335-2.Peer-Reviewed Original Research
2019
Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort
Aker A, McConnell R, Loch-Caruso R, Park S, Mukherjee B, Rosario Z, Vélez-Vega C, Huerta-Montanez G, Alshawabkeh A, Cordero J, Meeker J. Interactions between chemicals and non-chemical stressors: The modifying effect of life events on the association between triclocarban, phenols and parabens with gestational length in a Puerto Rican cohort. The Science Of The Total Environment 2019, 708: 134719. PMID: 31785910, PMCID: PMC6957748, DOI: 10.1016/j.scitotenv.2019.134719.Peer-Reviewed Original ResearchConceptsLife eventsLinear regression modelsMultiple linear regression modelNegative life eventsPresence of negative life eventsPsychosocial stress measuresAdverse birth outcomesPregnancy cohort studyRegression modelsEffects of psychosocial stressPsychosocial factorsNon-chemical stressorsBirth outcomesEffects of life eventsCohort studyPsychosocial stressPositive LEsPositive life eventsExposure biomarkersSignificant modifiersPrenatal exposureSignificant interactionWomenAssociationRate of eventsUrinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates
Ferguson K, Lan Z, Yu Y, Mukherjee B, McElrath T, Meeker J. Urinary concentrations of phenols in association with biomarkers of oxidative stress in pregnancy: Assessment of effects independent of phthalates. Environment International 2019, 131: 104903. PMID: 31288179, PMCID: PMC6728185, DOI: 10.1016/j.envint.2019.104903.Peer-Reviewed Original ResearchConceptsUrinary phthalate metabolitesOxidative stress biomarkersNon-null associationsPhthalate metabolitesBiomarkers of oxidative stressInterquartile rangeBenzophenone-3Associated with increasesOutcome biomarkersIncreased maternal oxidative stressStress biomarkersExposure to environmental phenolsOxidative stressReduced fetal growthUrinary oxidative stress biomarkersMaternal oxidative stressEffect estimatesAdaptive elastic net modelStudy populationPreterm birthFetal growthConcentration of phenolUrinary phenolPregnancyUrinary concentrationsA repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Calafat A, Cordero J, Meeker J. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019, 18: 28. PMID: 30940137, PMCID: PMC6444601, DOI: 10.1186/s12940-019-0459-5.Peer-Reviewed Original ResearchConceptsUrinary biomarkersAssociated with adverse birth outcomesAdverse birth outcomesPregnant womenBirth outcomesAdverse outcomesSerum hormonesStudy visitsParaben biomarkersThyroid hormonesParaben exposurePercent changeHormoneBiomarker concentrationsMaternal hormonesBiomarkersOutcomesVisitsAssociationExposureGestationRandom interceptPregnancyThyroid
2018
The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico. Environmental Research 2018, 169: 41-51. PMID: 30412856, PMCID: PMC6347499, DOI: 10.1016/j.envres.2018.10.030.Peer-Reviewed Original ResearchConceptsAssociated with gestational ageGestational ageOdds of SGAInfant sexBirth outcomesStudy visitsVisit 1Odds of preterm birthOdds of LGAAssociated with adverse birth outcomesBirthweight z-scoreBiomarker concentrationsAdverse birth outcomesPuerto Rico TestsitePreterm birthPregnant womenBirth weightUrinary biomarker concentrationsExposure biomarkersLogistic regression modelsVisit 3SGADecreased oddsZ-scoreCalculate oddsAssociations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study
Aung M, Ferguson K, Cantonwine D, Bakulski K, Mukherjee B, Loch-Caruso R, McElrath T, Meeker J. Associations between maternal plasma measurements of inflammatory markers and urinary levels of phenols and parabens during pregnancy: A repeated measures study. The Science Of The Total Environment 2018, 650: 1131-1140. PMID: 30308801, PMCID: PMC6236678, DOI: 10.1016/j.scitotenv.2018.08.356.Peer-Reviewed Original ResearchConceptsPlasma inflammatory markersInflammatory markersC-reactive proteinInterquartile range increaseFetal developmentImmunological biomarkersRange increaseTumor necrosis factor-aCase-control studyProspective birth cohortImmune system regulationHealthy pregnancyUrinary phenolSystemic inflammationImmunological mechanismsInterleukin-10Urinary levelsInterleukin-1bPregnancyStudy visitsMultivariate linear mixed modelReproductive outcomesMeasures of exposureInverse probability weightingUrine samplesAssociations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study
Aker A, Johns L, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment International 2018, 113: 341-349. PMID: 29366524, PMCID: PMC5866216, DOI: 10.1016/j.envint.2018.01.006.Peer-Reviewed Original ResearchConceptsThyroid hormonesAssociated with altered thyroid hormone levelsFetal health outcomesThyroid hormone levelsIQR increaseMultivariate regression analysisGestational ageMultivariate linear regression modelFetal neurodevelopmentPregnant womenFree thyroxinePotential biological mechanismsTime of exposureUrinary biomarkersCohort studyHormone levelsParaben biomarkersTotal triiodothyronineCase-control samplePregnancyBlood samplesTotal thyroxineHormone concentrationsHealth outcomesHormone
2017
Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis
Johns L, Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Urinary BPA and Phthalate Metabolite Concentrations and Plasma Vitamin D Levels in Pregnant Women: A Repeated Measures Analysis. Environmental Health Perspectives 2017, 125: 087026. PMID: 28934718, PMCID: PMC5783673, DOI: 10.1289/ehp1178.Peer-Reviewed Original ResearchConceptsCohort of pregnant womenMono-3-carboxypropyl phthalateVitamin D levelsPregnant womenD levelsNested case-control study of preterm birthMeasures of urinary phthalate metabolitesProspective cohort of pregnant womenOdds of vitamin D deficiencyCase-control study of preterm birthDi(2-ethylhexyl) phthalate metabolitesInverse associationStudy of preterm birthInterquartile rangePlasma vitamin D levelsCirculating total 25(OH)DNested case-control studyMetabolites of di(2-ethylhexyl) phthalateVitamin D deficiencyDi(2-ethylhexyl) phthalatePhthalate metabolite concentrationsUrinary phthalate metabolitesUrinary bisphenol AProspective birth cohortPreterm birthThyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study
Aung M, Johns L, Ferguson K, Mukherjee B, McElrath T, Meeker J. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study. Environment International 2017, 104: 33-40. PMID: 28410473, PMCID: PMC5497503, DOI: 10.1016/j.envint.2017.04.001.Peer-Reviewed Original ResearchConceptsThyroid hormone parametersHormonal parametersStudy visitsCases of preterm birthInterquartile rangeSupply of thyroid hormonesNormal birth outcomesUrinary bisphenol A concentrationsNested case-control studyThyrotropin (TSHContext of pregnancyUrinary BPA concentrationsUrinary bisphenol ACase-control studyIn vitro studiesPreterm birthTSH levelsMultivariate linear regression modelPregnant womenFetal developmentFree T4Visit 3Measures analysisBirth outcomesPregnancy
2016
Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy
Ferguson K, Cantonwine D, McElrath T, Mukherjee B, Meeker J. Repeated measures analysis of associations between urinary bisphenol-A concentrations and biomarkers of inflammation and oxidative stress in pregnancy. Reproductive Toxicology 2016, 66: 93-98. PMID: 27751756, PMCID: PMC5125888, DOI: 10.1016/j.reprotox.2016.10.002.Peer-Reviewed Original ResearchConceptsInterquartile range increaseBisphenol AOxidative stressRange increaseUrinary bisphenol A concentrationsC-reactive proteinBiomarkers of inflammationIL-6 concentrationsAdverse birth outcomesPrimary mechanism of actionAssociated with significant increasesRepeated measures analysisBisphenol A exposureBiomarkers of oxidative stressBisphenol A concentrationsMechanism of actionPregnant womenFetal developmentImpact pregnancyInflammation markersBirth outcomesOxidative stress biomarkersIL-6BPA exposurePregnancyUrinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth
Ferguson K, Meeker J, Cantonwine D, Chen Y, Mukherjee B, McElrath T. Urinary phthalate metabolite and bisphenol A associations with ultrasound and delivery indices of fetal growth. Environment International 2016, 94: 531-537. PMID: 27320326, PMCID: PMC4980186, DOI: 10.1016/j.envint.2016.06.013.Peer-Reviewed Original ResearchConceptsActual fetal weightUrinary phthalate metabolitesPhthalate metabolitesFetal weightFetal growthDi-2-ethylhexyl phthalate metabolitesNon-anomalous singleton pregnanciesAssociated with decreased fetal growthConcentrations of phthalate metabolitesTime pointsExposure to di-2-ethylhexyl phthalateSingleton pregnanciesLongitudinal birth cohortFetal sexDi-2-ethylhexyl phthalateInterquartile range increaseCross-sectional associationsUltrasound scanPregnancyInverse associationMaternal exposureDelivery indexUrine samplesStandard deviation decreaseBirth cohort
2015
Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy
Ferguson K, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Phthalate metabolites and bisphenol-A in association with circulating angiogenic biomarkers across pregnancy. Placenta 2015, 36: 699-703. PMID: 25913709, PMCID: PMC4441857, DOI: 10.1016/j.placenta.2015.04.002.Peer-Reviewed Original ResearchConceptsSFlt-1 to PlGF ratioSFlt-1Biomarkers of angiogenesisPhthalate metabolitesPlGF ratioPlacental developmentSoluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Tyrosine kinase-1Placental growth factorUrinary DEHP metabolitesProspective birth cohortAdverse birth outcomesCase-control populationDelivered pretermGestational ageAngiogenic biomarkersExposure to phthalatesUrinary biomarkersDEHP metabolitesBirth outcomesPlasma biomarkersPregnancyPlGFAssociated with decreasesUrinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth
Cantonwine D, Ferguson K, Mukherjee B, McElrath T, Meeker J. Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth. Environmental Health Perspectives 2015, 123: 895-901. PMID: 25815860, PMCID: PMC4559950, DOI: 10.1289/ehp.1408126.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthBisphenol A exposurePreterm premature rupture of membranesClinical classificationClassification of preterm birthSubcategories of preterm birthPremature rupture of membranesBisphenol A levelsCases of preterm birthAssociated with preterm birthSpontaneous preterm laborPreterm premature ruptureRupture of membranesSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProspective birth cohort studyUrinary bisphenol ACase-control studyAssociated with increased oddsA levelsTertiary teaching hospitalBirth cohort studyDelivered preterm
2013
Distribution, Variability, and Predictors of Urinary Concentrations of Phenols and Parabens among Pregnant Women in Puerto Rico
Meeker J, Cantonwine D, Rivera-González L, Ferguson K, Mukherjee B, Calafat A, Ye X, Del Toro L, Crespo-Hernández N, Jiménez-Vélez B, Alshawabkeh A, Cordero J. Distribution, Variability, and Predictors of Urinary Concentrations of Phenols and Parabens among Pregnant Women in Puerto Rico. Environmental Science And Technology 2013, 47: 3439-3447. PMID: 23469879, PMCID: PMC3638245, DOI: 10.1021/es400510g.Peer-Reviewed Original ResearchConceptsBenzophenone-3Bisphenol AConcentrations of bisphenol AConcentrations of triclosanPuerto RicoUrinary concentrations of triclosanNorthern Puerto RicoConcentration of phenolHuman exposureB-PbTriclosanIntraclass correlation coefficientFrequent detectionUrinary concentrationsMethyl parabenParabensPropyl parabenEndocrine-related diseasesPregnant womenReduce exposureButyl parabenWomen of reproductive agePuerto Rican pregnant womenConcentrationRico