2013
Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data
Ko Y, Saha‐Chaudhuri P, Park S, Vokonas P, Mukherjee B. Novel Likelihood Ratio Tests for Screening Gene‐Gene and Gene‐Environment Interactions With Unbalanced Repeated‐Measures Data. Genetic Epidemiology 2013, 37: 581-591. PMID: 23798480, PMCID: PMC4009698, DOI: 10.1002/gepi.21744.Peer-Reviewed Original ResearchConceptsGene-environment interactionsGene-gene interactionsTesting gene-gene interactionsModel gene-gene interactionsRepeated-measures studyLongitudinal cohort studyNormative Aging StudyCumulative lead exposureCase-control studyGene-environmentGene-geneType I error rateCohort studyScreening toolAging StudyLikelihood ratio testMain effectEpistasis patternsRatio testLead exposureHemochromatosis genePower propertiesPulse pressureRegression-based approachRestrictive assumptions
2012
Environmental Cadmium and Lead Exposures and Hearing Loss in U.S. Adults: The National Health and Nutrition Examination Survey, 1999 to 2004
Choi Y, Hu H, Mukherjee B, Miller J, Park S. Environmental Cadmium and Lead Exposures and Hearing Loss in U.S. Adults: The National Health and Nutrition Examination Survey, 1999 to 2004. Environmental Health Perspectives 2012, 120: 1544-1550. PMID: 22851306, PMCID: PMC3556613, DOI: 10.1289/ehp.1104863.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyPure-tone averageHealth and Nutrition Examination SurveyHearing lossNutrition Examination SurveyExamination SurveyU.S. adultsRisk factorsGeneral populationU.S. general populationBlood cadmiumHearing thresholdsNonoccupational noiseHearing abilityLow-level exposure to cadmiumLead exposureYears of ageClinical risk factorsU.S. populationExamination componentsEnvironmental cadmiumEpidemiological studiesHearingAnalyzed dataAdults
2011
Lead exposure and visual-motor abilities in children from Chennai, India
Palaniappan K, Roy A, Balakrishnan K, Gopalakrishnan L, Mukherjee B, Hu H, Bellinger D. Lead exposure and visual-motor abilities in children from Chennai, India. NeuroToxicology 2011, 32: 465-470. PMID: 21510976, PMCID: PMC3115626, DOI: 10.1016/j.neuro.2011.03.011.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBiomarkersChildChild BehaviorChild DevelopmentChild, PreschoolCross-Sectional StudiesDeveloping CountriesEnvironmental ExposureEnvironmental PollutantsFemaleHumansIndiaLeadLead Poisoning, Nervous System, ChildhoodLinear ModelsMaleNeuropsychological TestsPsychomotor PerformanceRisk AssessmentRisk FactorsSocioeconomic FactorsConceptsHigher blood lead levelsBlood lead levelsEducation levelMotor Ability TestUrban Indian childrenVisual-motor abilitiesCross-sectional studyMother's education levelFather's education levelAverage monthly incomeIndian childrenVisuo-motor developmentLead levelsMotor composite scoresMean blood lead levelLead exposureVisual-motorMonthly incomeDose-effect relationshipVisual-motor integrationComposite scoreSchool children
2010
Hemoglobin, Lead Exposure, and Intelligence Quotient: Effect Modification by the DRD2 Taq IA Polymorphism
Roy A, Hu H, Bellinger D, Mukherjee B, Modali R, Nasaruddin K, Schwartz J, Wright R, Ettinger A, Palaniapan K, Balakrishnan K. Hemoglobin, Lead Exposure, and Intelligence Quotient: Effect Modification by the DRD2 Taq IA Polymorphism. Environmental Health Perspectives 2010, 119: 144-149. PMID: 21205584, PMCID: PMC3018494, DOI: 10.1289/ehp.0901878.Peer-Reviewed Original ResearchConceptsDRD2 Taq IA polymorphismIntelligence quotientIQ pointsAssociated with higher IQDopamine D2 receptorsScale of IntelligenceProtective effect of hemoglobinLog blood leadD2 receptorsDRD2 polymorphismsHigher IQDRD2IA categoriesLead exposureCognitionGeneralized estimating equationsSignificant public health issueChildrenIntelligenceEffects of leadAnimal studiesChildren 3DopamineMassARRAY iPLEX platformHigher hemoglobin levelsCumulative lead exposure and age-related hearing loss: The VA Normative Aging Study
Park S, Elmarsafawy S, Mukherjee B, Spiro A, Vokonas P, Nie H, Weisskopf M, Schwartz J, Hu H. Cumulative lead exposure and age-related hearing loss: The VA Normative Aging Study. Hearing Research 2010, 269: 48-55. PMID: 20638461, PMCID: PMC2934752, DOI: 10.1016/j.heares.2010.07.004.Peer-Reviewed Original ResearchConceptsAge-related hearing lossPure-tone averagePatella lead levelsCumulative lead exposureHearing lossHearing thresholdsNormative Aging StudyAssociated with poorer hearing thresholdsOdds of hearing lossAir conduction hearing thresholdsAssociated with hearing lossConduction hearing thresholdsPoorer hearing thresholdsAging StudyDevelopment of age-related hearing lossReduction of lead exposureVA Normative Aging StudyCross-sectional analysisLead exposureOccupational noiseHearing abilityK X-ray fluorescencePotential confoundersEpidemiological researchLead levelsHFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
Zhang A, Park S, Wright R, Weisskopf M, Mukherjee B, Nie H, Sparrow D, Hu H. HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study. Environmental Health Perspectives 2010, 118: 1261-1266. PMID: 20478760, PMCID: PMC2944087, DOI: 10.1289/ehp.1002251.Peer-Reviewed Original ResearchConceptsCumulative lead exposureHFE H63D polymorphismC282Y variantBone lead levelsAssociated with steeper increasesLinear mixed-effects regression modelsFamily history of hypertensionMixed-effects regression modelsDaily intake of calciumNormative Aging StudyPredictor of cardiovascular diseaseWaist circumferenceIntake of calciumHistory of hypertensionLead exposureH63D polymorphismAlcohol intakeRandom interceptFamily historyMarker of arterial stiffnessTotal caloriesAging StudySteeper increasesLead levelsCardiovascular disease
2009
Bone Lead Level Prediction Models and Their Application to Examine the Relationship of Lead Exposure and Hypertension in the Third National Health and Nutrition Examination Survey
Park S, Mukherjee B, Xia X, Sparrow D, Weisskopf M, Nie H, Hu H. Bone Lead Level Prediction Models and Their Application to Examine the Relationship of Lead Exposure and Hypertension in the Third National Health and Nutrition Examination Survey. Journal Of Occupational And Environmental Medicine 2009, 51: 1422-1436. PMID: 19952788, PMCID: PMC2939477, DOI: 10.1097/jom.0b013e3181bf6c8d.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBone and BonesBostonCohort StudiesEnvironmental ExposureFemaleHumansHypertensionLeadLongitudinal StudiesMaleMiddle AgedNutrition SurveysPatellaRadiographyRegression AnalysisRisk AssessmentRisk FactorsSpectrometry, X-Ray EmissionTibiaUnited StatesUnited States Department of Veterans AffairsYoung AdultConceptsNational Health and Nutrition Examination SurveyThird National Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyCommunity-based cohortPatella leadExamination SurveyCohort of older menCommunity-based cohort of older menK X-ray fluorescenceNHANES-IIISignificant associationBlood lead levelsOlder menStandard covariatesPatellaExternal validationCorrelation coefficientBlood leadLead exposureTibiaLead levelsAssociationSurveyLead studies