2023
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks
Fritsche L, Nam K, Du J, Kundu R, Salvatore M, Shi X, Lee S, Burgess S, Mukherjee B. Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks. PLOS Genetics 2023, 19: e1010907. PMID: 38113267, PMCID: PMC10763941, DOI: 10.1371/journal.pgen.1010907.Peer-Reviewed Original ResearchConceptsPolygenic risk scoresMichigan Genomics InitiativeUK BiobankPre-existing conditionsPhenome-wide association studyAssociation studiesCohort-specific analysesPolygenic risk score approachUK Biobank cohortMeta-analysisIncreased risk of hospitalizationGenome-wide association studiesBody mass indexRisk of hospitalizationIdentified novel associationsRisk score approachCOVID-19 outcome dataCOVID-19 hospitalizationCOVID-19Mass indexRisk scoreBiobankCardiovascular conditionsCOVID-19 severityIncreased riskUsing Multi-Modal Electronic Health Record Data for the Development and Validation of Risk Prediction Models for Long COVID Using the Super Learner Algorithm
Jin W, Hao W, Shi X, Fritsche L, Salvatore M, Admon A, Friese C, Mukherjee B. Using Multi-Modal Electronic Health Record Data for the Development and Validation of Risk Prediction Models for Long COVID Using the Super Learner Algorithm. Journal Of Clinical Medicine 2023, 12: 7313. PMID: 38068365, PMCID: PMC10707399, DOI: 10.3390/jcm12237313.Peer-Reviewed Original ResearchComposite risk scoreRisk scoreElectronic health recordsAnalyses identified several factorsValidation of risk prediction modelsModerate discriminatory abilityRisk prediction modelPost-acute sequelae of COVID-19Health recordsCombined risk scorePost-acuteIdentification of individualsPrevention effortsSuper Learner algorithmMedical recordsHealthcare challengesPublic healthMedical phenotypesCOVID-19Increased riskPredictive factorsCOVID-19 infectionRecord DataPost-acute sequelaeHigh riskCharacterizing and Predicting Post-Acute Sequelae of SARS CoV-2 Infection (PASC) in a Large Academic Medical Center in the US
Fritsche L, Jin W, Admon A, Mukherjee B. Characterizing and Predicting Post-Acute Sequelae of SARS CoV-2 Infection (PASC) in a Large Academic Medical Center in the US. Journal Of Clinical Medicine 2023, 12: 1328. PMID: 36835863, PMCID: PMC9967320, DOI: 10.3390/jcm12041328.Peer-Reviewed Original ResearchPost-Acute Sequelae of SARS CoV-2 infectionElectronic health record dataPhenotype risk scoreHealth record dataCase-control study designPhenome-wide scanAcademic medical centerRisk prediction modelPost-COVID-19Risk stratification approachStudy designRecord dataRisk scoreHistory of COVID-19Medical CenterCOVID-19Increased riskPre-COVID-19Post-acute sequelaePre-COVID-19 periodRiskPost-COVID-19 periodCohortStratification approachSARS CoV-2 infectionCOVID-19 outcomes by cancer status, site, treatment, and vaccination
Salvatore M, Hu M, Beesley L, Mondul A, Pearce C, Friese C, Fritsche L, Mukherjee B. COVID-19 outcomes by cancer status, site, treatment, and vaccination. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 748-759. PMID: 36626383, DOI: 10.1158/1055-9965.epi-22-0607.Peer-Reviewed Original ResearchConceptsCOVID-19 outcomesCancer statusCancer diagnosisAssociated with higher ratesElectronic health record dataHealth record dataColorectal cancerIncreased riskAcademic medical centerKidney cancerCancer-free patientsIntensive care unit admissionCancer sitesAssociated with lower ratesChemotherapy receiptHigher ratesCOVID-19 precautionsRecord dataCOVID-19Logistic regressionMedical CenterUnit admissionRetrospective cohortVaccination statusLung cancer
2022
A Case-Crossover Phenome-wide association study (PheWAS) for understanding Post-COVID-19 diagnosis patterns
Haupert S, Shi X, Chen C, Fritsche L, Mukherjee B. A Case-Crossover Phenome-wide association study (PheWAS) for understanding Post-COVID-19 diagnosis patterns. Journal Of Biomedical Informatics 2022, 136: 104237. PMID: 36283580, PMCID: PMC9595430, DOI: 10.1016/j.jbi.2022.104237.Peer-Reviewed Original ResearchConceptsPhenome-wide association studyPost-COVID-19 conditionCOVID-19 survivorsCohort of COVID-19 survivorsAssociation studiesMental health disordersConditional logistic regressionWithin-person confoundingSARS-CoV-2 infectionRobust study designsProportion of COVID-19 survivorsPost-COVID-19Healthcare needsMental healthSARS-CoV-2Circulatory diseasesPhenotype codesHealth disordersSARS-CoV-2 positivityStudy designSARS-CoV-2 positive patientsLogistic regressionPheWASPost-COVID-19 infectionCOVID-19Estimating COVID-19 Vaccination and Booster Effectiveness Using Electronic Health Records From an Academic Medical Center in Michigan
Roberts E, Gu T, Wagner A, Mukherjee B, Fritsche L. Estimating COVID-19 Vaccination and Booster Effectiveness Using Electronic Health Records From an Academic Medical Center in Michigan. AJPM Focus 2022, 1: 100015. PMID: 36942016, PMCID: PMC9323299, DOI: 10.1016/j.focus.2022.100015.Peer-Reviewed Original ResearchIntensive care unit admissionElectronic health record dataHealth record dataElectronic health recordsMedical CenterUnit admissionAcademic medical centerOdds of vaccinationHealth recordsSevere COVID-19 outcomesAffluent areasHealthcare workersStudy designRecord dataCalendar quarterCOVID-19COVID-19 outcomesDisease overallUniversity of Michigan Medical CenterObservational studySevere COVID-19SARS-CoV-2 infectionVaccine effectivenessBooster statusOngoing surveillanceAssessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis
Clark-Boucher D, Boss J, Salvatore M, Smith J, Fritsche L, Mukherjee B. Assessing the added value of linking electronic health records to improve the prediction of self-reported COVID-19 testing and diagnosis. PLOS ONE 2022, 17: e0269017. PMID: 35877617, PMCID: PMC9312965, DOI: 10.1371/journal.pone.0269017.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsCOVID-19-related outcomesCOVID-19 testingSurvey respondentsSelf-reported outcomesSelf-reported dataCOVID-19 outcomesElectronic recordsSurvey dataCOVID-19Prediction modelModel contextSurveyCOVID-19 diagnosisOutcomesPredictor variablesDigital surveyData sourcesCoronavirus disease 2019RespondentsPredictorsCOVID-19 casesDiagnosisRecordsGlobal Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review
Chen C, Haupert S, Zimmermann L, Shi X, Fritsche L, Mukherjee B. Global Prevalence of Post-Coronavirus Disease 2019 (COVID-19) Condition or Long COVID: A Meta-Analysis and Systematic Review. The Journal Of Infectious Diseases 2022, 226: 1593-1607. PMID: 35429399, PMCID: PMC9047189, DOI: 10.1093/infdis/jiac136.Peer-Reviewed Original ResearchConceptsPost-COVID-19 conditionCondition prevalenceMeta-analysisGlobal prevalenceHealth effects of COVID-19Prevalence of post-COVID-19 conditionRegional prevalence estimationHealthcare systemPrevalence estimatesPooled prevalencePost-COVID-19Systematic reviewDerSimonian-Laird estimatorMeta-analyzedMemory problemsHealth effectsPrevalenceEffects of COVID-19Post-coronavirus disease 2019Long COVIDCOVID-19COVID-19 conditionsNonhospitalized patientsUnited States
2021
Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan
Zhao Z, Salerno S, Shi X, Lee S, Mukherjee B, Fritsche L. Understanding the Patterns of Serological Testing for COVID-19 Pre- and Post-Vaccination Rollout in Michigan. Journal Of Clinical Medicine 2021, 10: 4341. PMID: 34640359, PMCID: PMC8509702, DOI: 10.3390/jcm10194341.Peer-Reviewed Original ResearchNon-Hispanic black race/ethnicityRegional health centersEver-smoking statusHealth centersBlack race/ethnicityAssociated with ageCirculatory diseasesSARS-CoV-2 antibody testingMichigan MedicinePre-existing conditionsNeighborhood variablesCOVID-19SARS-CoV-2 antibodiesSARS-CoV-2Vaccinated individualsVaccine-induced immunityRespiratory diseaseIndividualsCOVID-19 infectionExploratory analysisLiver diseaseAgeSerological testsCOVID-19 Pandemic in India: Through the Lens of Modeling
Babu G, Ray D, Bhaduri R, Halder A, Kundu R, Menon G, Mukherjee B. COVID-19 Pandemic in India: Through the Lens of Modeling. Global Health Science And Practice 2021, 9: 220-228. PMID: 34234020, PMCID: PMC8324184, DOI: 10.9745/ghsp-d-21-00233.Peer-Reviewed Original ResearchA Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine
Salvatore M, Gu T, Mack J, Sankar S, Patil S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. A Phenome-Wide Association Study (PheWAS) of COVID-19 Outcomes by Race Using the Electronic Health Records Data in Michigan Medicine. Journal Of Clinical Medicine 2021, 10: 1351. PMID: 33805886, PMCID: PMC8037108, DOI: 10.3390/jcm10071351.Peer-Reviewed Original ResearchPhenome-wide association studyCOVID-19 outcomesIntensive care unitAssociation studiesNon-Hispanic blacksNon-Hispanic whitesAcademic medical centerAssociated with hospitalizationHealthcare deliveryAssociated with mortalityMedicine backgroundPre-existing conditionsMedical phenomeDisease preventionVulnerable populationsPulmonary heart diseaseTargeted screeningMental disordersCOVID-19Associated with intensive care unitMedical CenterRecord DataCare unitGenitourinary conditionsHeart disease
2020
Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes
Salerno S, Zhao Z, Sankar S, Salvatore M, Gu T, Fritsche L, Lee S, Lisabeth L, Valley T, Mukherjee B. Patterns of repeated diagnostic testing for COVID‐19 in relation to patient characteristics and outcomes. Journal Of Internal Medicine 2020, 289: 726-737. PMID: 33253457, PMCID: PMC7753604, DOI: 10.1111/joim.13213.Peer-Reviewed Original ResearchConceptsAssociated with repeat testingFalse-negative rateNeighborhood poverty levelPre-existing type 2 diabetesSevere COVID-19-related outcomesDiagnostic testsPatient characteristicsPre-existing kidney diseaseBody mass indexICU-level careHealth outcomesCOVID-19-related outcomesCharacteristics of patientsCOVID-19 diagnostic testsType 2 diabetesMichigan MedicineMass indexCOVID-19Pain symptomsPatient agePoverty levelDownstream outcomesKidney diseaseRepeated testingLiver diseaseComprehensive public health evaluation of lockdown as a non-pharmaceutical intervention on COVID-19 spread in India: national trends masking state-level variations
Salvatore M, Basu D, Ray D, Kleinsasser M, Purkayastha S, Bhattacharyya R, Mukherjee B. Comprehensive public health evaluation of lockdown as a non-pharmaceutical intervention on COVID-19 spread in India: national trends masking state-level variations. BMJ Open 2020, 10: e041778. PMID: 33303462, PMCID: PMC7733201, DOI: 10.1136/bmjopen-2020-041778.Peer-Reviewed Original ResearchConceptsEffective public health interventionsPublic health interventionsPublic health evaluationPublic health metricsAverage daily numberHealth interventionsState-level trendsHealth metricsTest positivity rateCohort studyCase fatality rateHealth evaluationNational trendsCOVID-19Holistic assessmentDaily numberConfirmed COVID-19 casesCOVID-19 pandemicNational patternsNational lockdownInterventionCOVID-19 outbreakFatality rateCase countsState-wise variationsAre women leaders significantly better at controlling the contagion during the COVID-19 pandemic?
Purkayastha S, Salvatore M, Mukherjee B. Are women leaders significantly better at controlling the contagion during the COVID-19 pandemic? Journal Of Health And Social Sciences 2020, 5: 231-240. PMID: 32875269, PMCID: PMC7457824.Peer-Reviewed Original Research