2006
Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-κB, and AP-1
Ueno H, Pradhan S, Schlessel D, Hirasawa H, Sumpio BE. Nicotine enhances human vascular endothelial cell expression of ICAM-1 and VCAM-1 via protein kinase C, p38 mitogen-activated protein kinase, NF-κB, and AP-1. Cardiovascular Toxicology 2006, 6: 39-50. PMID: 16845181, DOI: 10.1385/ct:6:1:39.Peer-Reviewed Original ResearchConceptsHuman umbilical vein endothelial cellsICAM-1VCAM-1NF-κBAdhesion moleculesP38 mitogen-activated protein kinaseProtein kinase CMitogen-activated protein kinaseVascular cell adhesion moleculeEndothelial cellsExposure of HUVECsCellular adhesion molecule expressionAP-1Vascular endothelial cell expressionMajor risk factorEffects of nicotineEtiology of atherosclerosisP38 MAPKAdhesion molecule expressionIntercellular adhesion moleculeTranscription factor NF-κBCellular adhesion moleculesEndothelial cell expressionFactor NF-κBUmbilical vein endothelial cells
2003
Immunobiologic analysis of arterial tissue in Buerger's disease
Lee T, Seo J, Sumpio BE, Kim SJ. Immunobiologic analysis of arterial tissue in Buerger's disease. European Journal Of Vascular And Endovascular Surgery 2003, 25: 451-457. PMID: 12713785, DOI: 10.1053/ejvs.2002.1869.Peer-Reviewed Original ResearchConceptsThromboangiitis obliteransT cellsVaso vasorumI-NOSVCAM-1Endothelial cellsDegree of recanalizationT lymphocyte infiltrationCD4 T cellsInflammatory cytokine detectionInterferon-gamma mRNABuerger's diseasePatent arteriesCD8 cellsImmunologic injuryLymphocyte infiltrationImmune inflammationImmune injuryLuminal obliterationEtiologic mechanismsTUNEL studiesCell activationArterial wallRT-PCRCytokine detection