1993
Captopril renal scintigraphy: A new standard for predicting outcome after renal revascularization
Meier G, Sumpio B, Setaro J, Black H, Gusberg R. Captopril renal scintigraphy: A new standard for predicting outcome after renal revascularization. Journal Of Vascular Surgery 1993, 17: 280-287. PMID: 8433423, DOI: 10.1016/0741-5214(93)90413-g.Peer-Reviewed Original ResearchConceptsCaptopril renal scintigraphyCaptopril-induced changesRenal revascularizationHypertension responseBlood pressureAmerican Heart Association criteriaDose of captoprilGlomerular filtration rateCessation of administrationNuclear medicine techniquesCaptopril administrationStandard renogramRenovascular diseaseBalloon angioplastyVascular toneRenal scintigraphyFiltration rateBaseline scanRevascularizationStudy groupAssociation criteriaPatientsEnzyme inhibitorsMedicine techniquesRenogram
1987
Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity.
Sumpio B, Baue A, Chaudry I. Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987, 101: 315-22. PMID: 2950608.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateRenal perfusate flowTubular absorptionPerfusate flowUrine outputImmunosuppressive agentsVerapamil pretreatmentClearance periodMicrograms/ATP-MgCl2 treatmentControl clearance periodsUse of cyclosporineCombination of verapamilSerious side effectsTissue ATP levelsEffects of adenosineCyA treatmentCyA nephrotoxicityCyclosporine nephrotoxicityVerapamil treatmentTubular functionRenal flowNephrotoxic potentialFiltration rateATP-MgCl2
1985
Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorption