2003
An appraisal of different cardiac risk reduction strategies in vascular surgery patients
Kakisis JD, Abir F, Liapis CD, Sumpio BE. An appraisal of different cardiac risk reduction strategies in vascular surgery patients. European Journal Of Vascular And Endovascular Surgery 2003, 25: 493-504. PMID: 12787690, DOI: 10.1053/ejvs.2002.1851.Peer-Reviewed Original ResearchConceptsVascular surgeryPerioperative mortalityVascular proceduresAvailable pharmacological agentsCardiac risk reductionCoronary artery bypassVascular surgery patientsLow-risk patientsMyocardial infarction ratePercutaneous transluminal angioplastyCalcium channel blockersArtery bypassCardiac morbidityCardiac mortalityCoronary revascularizationInfarction ratePerioperative outcomesSurgery patientsTransluminal angioplastyOverall mortalityCardiac riskCardioprotective effectsPerioperative settingChannel blockersOutcome measures
1998
Calcium-Independent Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Cyclic Strain
Ikeda M, Takei T, Mills I, Sumpio B. Calcium-Independent Activation of Extracellular Signal-Regulated Kinases 1 and 2 by Cyclic Strain. Biochemical And Biophysical Research Communications 1998, 247: 462-465. PMID: 9642151, DOI: 10.1006/bbrc.1998.8811.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalcium Channel BlockersCalcium-Calmodulin-Dependent Protein KinasesCattleCells, CulturedChelating AgentsEgtazic AcidEndothelium, VascularEnzyme ActivationExtracellular SpaceGadoliniumHydroquinonesIntracellular FluidMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesPhosphorylationStress, MechanicalConceptsEndothelial cellsActivation of ERK1/2Baseline phosphorylationExtracellular Ca2Normal extracellular Ca2Aortic endothelial cellsKinase 1Bovine aortic endothelial cellsStrain-induced activationCycles/minChannel blockersExtracellular signal-regulated kinases 1Signal-regulated kinases 1Calcium-independent activationBenzohydroquinoneERK1/2 activationERK1/2Free mediumEffect of Ca2ActivationCa2EGTA