African Trypanosome-Induced Blood–Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation
Sumpio BJ, Chitragari G, Moriguchi T, Shalaby S, Pappas-Brown V, Khan AM, Sekaran SD, Sumpio BE, Grab DJ. African Trypanosome-Induced Blood–Brain Barrier Dysfunction under Shear Stress May Not Require ERK Activation. International Journal Of Angiology 2014, 24: 41-46. PMID: 27053915, PMCID: PMC4813428, DOI: 10.1055/s-0034-1370890.Peer-Reviewed Original ResearchHuman brain microvascular endothelial cellsBrain microvascular endothelial cellsTransendothelial electrical resistanceBlood-brain barrierBrain postcapillary venulesBrain barrier dysfunctionMicrovascular endothelial cellsPhosphorylation of ERK1/2Parasite cysteine proteasesNeurological symptomsBBB permeabilityBarrier dysfunctionExtracellular signal-regulated kinaseBrain capillariesMicrovascular permeabilityAbsence of trypanosomesHuman African trypanosomiasisSignal-regulated kinasePostcapillary venulesTransient increaseEndothelial cellsBarrier functionElectric cell-substrate impedance sensingProtozoan parasiteTrypanosome infection