2015
Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection
Jhingran A, Kasahara S, Shepardson KM, Junecko BA, Heung LJ, Kumasaka DK, Knoblaugh SE, Lin X, Kazmierczak BI, Reinhart TA, Cramer RA, Hohl TM. Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection. PLOS Pathogens 2015, 11: e1004589. PMID: 25621893, PMCID: PMC4306481, DOI: 10.1371/journal.ppat.1004589.Peer-Reviewed Original ResearchConceptsRespiratory fungal infectionsDistinct signal transduction pathwaysSignal transduction pathwaysNeutrophil recruitmentChemokine inductionGenetic deletionFungal infectionsFungal clearanceCellular compartmentsTransduction pathwaysC-type lectinProtein triggersLung epithelial cellsNeutrophil-dependent host defenseInterleukin-1 receptorReceptor signalsConidial uptakeLung neutrophil recruitmentLung-infiltrating neutrophilsNeutrophil chemokines CXCL1Sequential rolesMyD88-deficient miceHematopoietic compartmentProtein knockout miceMajor cellular source
2011
Airway Epithelial MyD88 Restores Control of Pseudomonas aeruginosa Murine Infection via an IL-1–Dependent Pathway
Mijares LA, Wangdi T, Sokol C, Homer R, Medzhitov R, Kazmierczak BI. Airway Epithelial MyD88 Restores Control of Pseudomonas aeruginosa Murine Infection via an IL-1–Dependent Pathway. The Journal Of Immunology 2011, 186: 7080-7088. PMID: 21572023, PMCID: PMC3110630, DOI: 10.4049/jimmunol.1003687.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsHumansImmunity, InnateInterleukin-1MiceMice, KnockoutMyeloid Differentiation Factor 88Pseudomonas aeruginosaPseudomonas InfectionsRespiratory MucosaSignal TransductionConceptsInnate immune responseImmune responseMyD88-dependent innate immune responsesIL-1-dependent pathwayBone marrow chimeric miceProtective innate immune responseP. aeruginosaNovel transgenic mouse modelVentilator-associated pneumoniaIL-1R signalingTransgenic mouse modelP. aeruginosa infectionEpithelial cell responsesRadio-resistant cellsIntranasal infectionMyD88 expressionMultiple TLR pathwaysMyD88 functionAeruginosa infectionMouse modelTLR pathwayMurine infectionChimeric miceCell responsesInfection