2024
Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE
Fiske H, Ward C, Shah S, Holubar S, Al-Bawardy B, Barnes E, Binion D, Bohm M, Brand M, Clarke K, Cohen B, Cross R, Dueker J, Engels M, Farraye F, Fine S, Forster E, Gaidos J, Ginsburg P, Goyal A, Hanson J, Herfath H, Hull T, Kelly C, Lazarev M, Levy L, Melia J, Philpott J, Qazi T, Siegel C, Watson A, Wexner S, Williams E, Regueiro M. Clinical Decision Making in Inflammatory Bowel Disease Mimics: Practice Management from Inflammatory Bowel Disease LIVE. Crohn's & Colitis 360 2024, 6: otae022. PMID: 38720935, PMCID: PMC11078036, DOI: 10.1093/crocol/otae022.Peer-Reviewed Original ResearchInflammatory bowel diseaseReview of patient historyPresentation of inflammatory bowel diseaseInflammatory bowel disease patientsTreated with biologicsCost of patient careClinical management implicationsReassessment of treatmentIBD specialistsClinical responseMedication-inducedIBD patientsPrescribed steroidsPatient careEndoscopic biopsyTherapeutic workupMultidisciplinary managementIBD casesBalloon enteroscopyAdverse eventsDifferential diagnosisDisease mimicsDiverse presentationsPatient historyBowel disease
2023
ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis
Mann J, Lucca L, Austin M, Merkin R, Robert M, Al Bawardy B, Raddassi K, Aizenbud L, Joshi N, Hafler D, Abraham C, Herold K, Kluger H. ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis. Journal For ImmunoTherapy Of Cancer 2023, 11: e007358. PMID: 37586769, PMCID: PMC10432652, DOI: 10.1136/jitc-2023-007358.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsT cell subsetsCheckpoint inhibitorsImmune environmentImmune checkpoint inhibitor-induced colitisCheckpoint inhibitor-induced colitisPeripheral immune environmentsStages of colitisTreatment of colitisMerkel cell carcinomaT cell populationsPeripheral blood samplesCourse of progressionT cell receptorMultiple tumor typesAlternative cancer therapyCommon toxicitiesICI colitisTreatment discontinuationAdverse eventsBiologic therapyImmune suppressionCell carcinomaColitisBlood samples
2022
Open-Capsule Budesonide for the Treatment of Isolated Immune Checkpoint Inhibitor-Induced Enteritis
Hussain N, Robert M, Al-Bawardy B. Open-Capsule Budesonide for the Treatment of Isolated Immune Checkpoint Inhibitor-Induced Enteritis. ACG Case Reports Journal 2022, 9: e00882. PMID: 36237281, PMCID: PMC9553371, DOI: 10.14309/crj.0000000000000882.Peer-Reviewed Original Research
2018
Outcomes of repeat balloon assisted enteroscopy in small-bowel bleeding
Al-Bawardy B, Ramos G, Lennon R, Gorospe E, Song L, Bruining D, Alexander J, Coelho-Prabhu N, Fidler J, Rajan E. Outcomes of repeat balloon assisted enteroscopy in small-bowel bleeding. Endoscopy International Open 2018, 06: e694-e699. PMID: 29868634, PMCID: PMC5979197, DOI: 10.1055/a-0599-6085.Peer-Reviewed Original ResearchSmall bowel bleedingTherapeutic yieldAdverse eventsAntegrade routeOnly significant predictive factorChronic obstructive pulmonary diseaseSelf-limited abdominal painChronic kidney diseaseAdverse event ratesObstructive pulmonary diseaseSignificant predictive factorsCardiac comorbiditiesRepeat balloonAbdominal painSecondary outcomesPrimary outcomePulmonary diseaseRetrospective reviewPredictive factorsKidney diseaseBACKGROUND/Diagnostic yieldNegative groupMultivariate analysisEvent ratesOutcomes of endoscopic intervention for overt GI bleeding in severe thrombocytopenia
Ramos GP, Binder M, Hampel P, Braga Neto MB, Sunjaya D, Al Bawardy B, Abu Dayyeh BK, Buttar NS, Bruining DH, Prabhu-Coelho N, Larson MV, Wong Kee Song LM, Rajan E. Outcomes of endoscopic intervention for overt GI bleeding in severe thrombocytopenia. Gastrointestinal Endoscopy 2018, 88: 55-61. PMID: 29408558, DOI: 10.1016/j.gie.2018.01.028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCause of DeathCohort StudiesComorbidityEndoscopy, GastrointestinalErythrocyte TransfusionFemaleGastrointestinal HemorrhageHematemesisHemostasis, SurgicalHumansHypotensionIntensive Care UnitsInternational Normalized RatioLiver CirrhosisLung DiseasesMaleMelenaMiddle AgedMortalityPartial Thromboplastin TimePlatelet TransfusionRecurrenceRetrospective StudiesRisk FactorsSeverity of Illness IndexThrombocytopeniaYoung AdultConceptsIncreased international normalized ratioOvert gastrointestinal bleedingInitial hemostasis rateRecurrent bleeding rateGastrointestinal bleedingLiver cirrhosisSevere thrombocytopeniaPlatelet transfusionsPlatelet countTherapeutic yieldRecurrent bleedingHemostasis rateAdverse eventsBleeding rateHigh initial hemostasis rateIntensive care unit admissionCare unit admissionPredictors of mortalityCause mortality ratesMedian platelet countHours of presentationInternational normalized ratioSetting of thrombocytopeniaProcedural adverse eventsPartial thromboplastin time
2017
Endoscopic muscle biopsy sampling of the duodenum and rectum: a pilot survival study in a porcine model to detect myenteric neurons
Rajan E, Al-Bawardy B, Gostout CJ, Wong Kee Song LM, Deters JL, Knipschield MA, Bernard CE, Farrugia G. Endoscopic muscle biopsy sampling of the duodenum and rectum: a pilot survival study in a porcine model to detect myenteric neurons. Gastrointestinal Endoscopy 2017, 87: 600-606. PMID: 28734992, PMCID: PMC5775930, DOI: 10.1016/j.gie.2017.07.023.Peer-Reviewed Original ResearchConceptsMuscle biopsy samplingProtein gene product 9.5Myenteric neuronsMuscularis propriaGene product 9.5Biopsy samplingSnare electrocauteryUpper endoscopyProduct 9.5Scope clipDuodenal wallBand ligation techniqueFunctional bowel disordersSlow transit constipationProcedural adverse eventsRectal muscularis propriaIntermuscular layerAdverse eventsBowel disordersClinical courseMotility disordersSmall bowelSurgical approachTissue diagnosisPreclinical studies
2016
Over-the-scope clip-assisted endoscopic full-thickness resection of epithelial and subepithelial GI lesions
Al-Bawardy B, Rajan E, Wong Kee Song LM. Over-the-scope clip-assisted endoscopic full-thickness resection of epithelial and subepithelial GI lesions. Gastrointestinal Endoscopy 2016, 85: 1087-1092. PMID: 27569858, DOI: 10.1016/j.gie.2016.08.019.Peer-Reviewed Original ResearchConceptsEndoscopic full-thickness resectionConventional resection techniquesFull-thickness resectionAdverse eventsResection techniquesEpithelial lesionsHistopathologic diagnosisR0 resection statusMean lesion sizeSessile serrated adenomasR0 resectionEndoscopic findingsResection statusBloc resectionElectrosurgical snareRectosigmoid colonGI lesionsMean ageDefinitive diagnosisNeuroendocrine tumorsSubepithelial lesionsPancreatic heterotopiaSafe techniquePadlock clipSerrated adenomasOutcomes and Predictors of Rebleeding After 2-Octyl Cyanoacrylate Injection in Acute Gastric Variceal Hemorrhage
Al-Bawardy B, Gorospe EC, Saleem A, Buttar NS, Song L. Outcomes and Predictors of Rebleeding After 2-Octyl Cyanoacrylate Injection in Acute Gastric Variceal Hemorrhage. Journal Of Clinical Gastroenterology 2016, 50: 458-463. PMID: 26890326, DOI: 10.1097/mcg.0000000000000487.Peer-Reviewed Original ResearchConceptsAcute gastric variceal hemorrhageGastric variceal obturationGastric variceal hemorrhageVariceal hemorrhageAdverse eventsPulmonary embolismEnd-stage liver disease (MELD) scoreGastric varices type 1Gastric variceal rebleedingLiver Disease scoreMetastatic hepatocellular carcinomaAcute hemostasisCyanoacrylate injectionHospital mortalityHospital rebleedingSarin classificationVariceal rebleedingEndoscopic injectionGastric varicesPulmonary emboliRenal failureHemorrhagic strokeInitial hemostasisVariceal obturationPatient cohortOutcomes of double-balloon enteroscopy-assisted direct percutaneous endoscopic jejunostomy tube placement
Al-Bawardy B, Gorospe EC, Alexander JA, Bruining DH, Coelho-Prabhu N, Rajan E, Wong Kee Song LM. Outcomes of double-balloon enteroscopy-assisted direct percutaneous endoscopic jejunostomy tube placement. Endoscopy 2016, 48: 552-556. PMID: 26964079, DOI: 10.1055/s-0042-101853.Peer-Reviewed Original ResearchConceptsJejunostomy tube placementAdverse eventsTube placementPost-procedural adverse eventsStudy aimDPEJ tube placementSerious adverse eventsSignificant adverse eventsMean procedure durationDouble-balloon enteroscopyTechnical success ratePatient demographicsCommon indicationSurgical repairGastric interpositionTechnical successMedical recordsProcedure durationLarge cohortDPEJSurgical adhesionsGut anatomyPatientsConventional endoscopyLarge series