2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8EndometriosisPhyto-oestrogens and the endometrium
Arici A, Bukulmez O. Phyto-oestrogens and the endometrium. The Lancet 2004, 364: 2081-2082. PMID: 15589297, DOI: 10.1016/s0140-6736(04)17565-x.Peer-Reviewed Original Research
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisEstradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect
Seli E, Selam B, Mor G, Kayisli U, Pehlivan T, Arici A. Estradiol regulates monocyte chemotactic protein-1 in human coronary artery smooth muscle cells: a mechanism for its antiatherogenic effect. Menopause The Journal Of The North American Menopause Society 2001, 8: 296-301. PMID: 11449089, DOI: 10.1097/00042192-200107000-00013.Peer-Reviewed Original ResearchConceptsHuman coronary artery smooth muscle cellsCoronary artery smooth muscle cellsArtery smooth muscle cellsMonocyte chemotactic protein-1Smooth muscle cellsChemotactic protein-1Recruitment of macrophagesMCP-1 expressionMCP-1 proteinMuscle cellsProtective effectProtein 1Arterial wallSelective estrogen receptor modulatorsCoronary smooth muscle cellsMCP-1 protein productionEstrogen's protective effectPhenol red-free mediumCharcoal-stripped calf serumProtein productionEstrogen receptor modulatorsPathogenesis of atherosclerosisReverse transcriptase-polymerase chain reactionNorthern blotLow-density lipoproteinExpression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometrium
1999
Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalRegulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata
Sozen I, Olive D, Arici A. Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata. Fertility And Sterility 1998, 69: 1095-1102. PMID: 9627299, DOI: 10.1016/s0015-0282(98)00072-7.Peer-Reviewed Original ResearchConceptsMCP-1 mRNA levelsChemotactic protein-1MCP-1Leiomyoma cellsSex steroidsHigher MCP-1 levelsSteroid hormonesMCP-1 protein productionMonocyte chemotactic protein-1MCP-1 levelsMRNA levelsProtein 1Proliferative phase samplesImmunoreactive MCP-1MCP-1 expressionUniversity Medical CenterLeiomyoma cell proliferationParacrine growth factorMCP-1 mRNAGrowth stimulatory effectMessenger RNA levelsPathogenesis of leiomyomaLocal immunityGnRH analoguesProspective study
1996
Modulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1
Arici A, MacDonald P, Casey M. Modulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1. Biology Of Reproduction 1996, 54: 463-469. PMID: 8788200, DOI: 10.1095/biolreprod54.2.463.Peer-Reviewed Original ResearchConceptsTGF beta 3 mRNAEndometrial stromal cellsTGF beta 1 mRNATGF beta 1Beta 3 mRNAHuman endometrial stromal cellsBeta 1 mRNAPlatelet-derived growth factorStromal cellsBeta 1Proliferative phase endometrial tissueTGF beta 2 mRNATGF-beta mRNA levelsGrowth factorTGF beta 1 treatmentProliferative phase endometriumEstradiol-17 betaLate secretory phaseSecretory phase tissuesBeta 2 mRNABeta mRNA levelsGrowth factor betaDose-dependent mannerTotal RNATime-dependent fashion
1994
Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells
Marshburn P, Arici A, Casey M. Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells. American Journal Of Obstetrics And Gynecology 1994, 170: 1152-1158. PMID: 8166201, DOI: 10.1016/s0002-9378(94)70112-1.Peer-Reviewed Original ResearchConceptsEstradiol-17 betaEndometrial stromal cellsEndometrial glandsMessenger ribonucleic acidStromal cellsHuman endometriumDeoxyribonucleic acid synthesisGlandular epitheliumEpithelial cellsEndometrial glandular epitheliumEndometrial cell proliferationStromal cell originHuman endometrial cellsGrowth factor-β1Acid synthesisRibonucleic acidSecretory endometriumEndometrial cellsTrichloroacetic acid-precipitable materialEndometrial epitheliumSecretory phaseFactor-β1Cell originAcid-precipitable materialEndometrium