2001
Effect of gonadotropin-releasing hormone agonists on monocyte chemotactic protein-1 production and macrophage infiltration in leiomyomatous uterus
Sozen I, Senturk L, Arici A. Effect of gonadotropin-releasing hormone agonists on monocyte chemotactic protein-1 production and macrophage infiltration in leiomyomatous uterus. Fertility And Sterility 2001, 76: 792-796. PMID: 11591415, DOI: 10.1016/s0015-0282(01)02378-0.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1Leiomyomatous uterusMacrophage countGonadotropin-releasing hormone agonistDirect paracrine effectChemotactic protein-1 productionMCP-1 levelsChemotactic protein-1MCP-1 stainingCross-sectional studyMyometrium of womenMCP-1 expressionMonocyte chemotactic protein-1 productionMCP-1 protein expressionUniversity Medical CenterProtein-1 productionGnRH agonistHormone agonistMacrophage infiltrationMedical CenterMAIN OUTCOMEImmunohistochemical analysisLeiomyoma cellsParacrine effectsGnRHInterleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Senturk L, Sozen I, Gutierrez L, Arici A. Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. American Journal Of Obstetrics And Gynecology 2001, 184: 559-566. PMID: 11262453, DOI: 10.1067/mob.2001.111160.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DivisionDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleGonadotropin-Releasing HormoneHumansImmunohistochemistryInterleukin-1Interleukin-8KineticsLeiomyomaMyometriumReceptors, Interleukin-8ARNA, MessengerTumor Cells, CulturedTumor Necrosis Factor-alphaUterine NeoplasmsConceptsInterleukin-8 productionTumor necrosis factor alphaNecrosis factor alphaInterleukin-8Factor alphaInterleukin-1alphaMyometrial cellsCell proliferationInterleukin-8 receptor expressionGonadotropin-releasing hormone agonistType APotent chemoattractant cytokinesDose-dependent increaseMyometrial cell proliferationMessenger ribonucleic acid expressionDose-dependent inhibitionEnzyme-linked immunosorbentRibonucleic acid expressionLeiomyomatous tissueLeiomyomatous uterusHormone agonistHuman myometriumReceptor expressionChemoattractant cytokinesMyometrial tissue
2000
Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
Arici A, Sozen I. Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertility And Sterility 2000, 73: 1006-1011. PMID: 10785229, DOI: 10.1016/s0015-0282(00)00418-0.Peer-Reviewed Original ResearchConceptsTGF-beta3 mRNA levelsLeiomyoma cell proliferationCell proliferationLeiomyoma cellsFibronectin expressionMRNA levelsLeiomyoma samplesProliferative phase samplesTGF-beta3 mRNAUniversity Medical CenterFibronectin mRNA expressionExpression of fibronectinMedical CenterFibrogenic processMAIN OUTCOMESex steroidsMidsecretory phaseMyometrial cellsMyometrial samplesLeiomyomaTGF-beta3MRNA expressionGrowth-promoting effectMyometriumGrowth factor β3
1999
Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populations
1998
Fas‐Fas Ligand System‐Induced Apoptosis in Human Placenta and Gestational Trophoblastic Disease
Mor G, Gutierrez L, Eliza M, Kahyaoglu F, Arici A. Fas‐Fas Ligand System‐Induced Apoptosis in Human Placenta and Gestational Trophoblastic Disease. American Journal Of Reproductive Immunology 1998, 40: 89-94. PMID: 9764350, DOI: 10.1111/j.1600-0897.1998.tb00396.x.Peer-Reviewed Original ResearchConceptsGestational trophoblastic diseaseTrophoblastic diseaseFasL expressionImmunobiology of pregnancyMaternal immune responseMaternal immune toleranceMaternal-fetal interfaceReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionNick-end labeling assayFas ligand expressionEnd-labeling assayPaternal alloantigensPathologic placentasImmune toleranceFetal antigensT cellsFas-FasLImmune responseNormal placentaLigand expressionPlacentaHuman placentaParaffin sectionsPathologic states
1995
Dilutional hyponatremia during hysteroscopic myomectomy with sorbitol-mannitol distention medium
Kim A, Keltz M, Arici A, Rosenberg M, Olive D. Dilutional hyponatremia during hysteroscopic myomectomy with sorbitol-mannitol distention medium. Journal Of Minimally Invasive Gynecology 1995, 2: 237-242. PMID: 9050566, DOI: 10.1016/s1074-3804(05)80026-x.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal PainAdultEndoscopyFemaleHumansHyponatremiaHysteroscopyIndicators and ReagentsLeiomyomaMaleMannitolMenorrhagiaMiddle AgedOrgan SizePelvic PainProstatectomyRetrospective StudiesSodiumSorbitolSyndromeTime FactorsUltrasonographyUterine NeoplasmsUterusWater IntoxicationWater-Electrolyte BalanceConceptsDegree of hyponatremiaHysteroscopic myoma resectionUterine volumeMyoma sizeFibroid volumeDilutional hyponatremiaMyoma resectionYale-New Haven HospitalOperative hysteroscopic proceduresPost-TURP syndromeMyoma volumeHysteroscopic myomectomyOperative timeHyponatremiaHysteroscopic proceduresFluid balanceDistension mediumDistention mediumReproductive endocrinologyOperating timeResectionSyndromeSorbitol-mannitolMyomectomyMyomas