2004
Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis
Luk J, Seval Y, Kayisli UA, Ulukus M, Ulukus CE, Arici A. Regulation of Interleukin-8 Expression in Human Endometrial Endothelial Cells: A Potential Mechanism for the Pathogenesis of Endometriosis. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1805-1811. PMID: 15613411, DOI: 10.1210/jc.2004-1813.Peer-Reviewed Original ResearchConceptsHuman endometrial endothelial cellsIL-8 mRNAEndometrial endothelial cellsIL-8 expressionSex steroidsEndothelial cellsEutopic endometriumCultured human endometrial endothelial cellsIL-8 immunoreactivityEffects of estradiolEutopic endometrial tissuesPathogenesis of endometriosisInterleukin-8 expressionMenstrual cycle phaseEndothelium-specific markersEndometriosis implantsInflammatory basisCytokine levelsEndometriotic implantsInflammatory mediatorsChemokine expressionEndometrial tissueInflammatory aspectsIL-8EndometriosisRegulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli U, Selam B, Arici A. Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro. Molecular Human Reproduction 2004, 10: 393-398. PMID: 15073283, DOI: 10.1093/molehr/gah060.Peer-Reviewed Original ResearchConceptsStromal cell survivalCell survivalStromal cellsVascular endothelial growth factorEndometrial stromal cellsPotent mitogenic cytokineFasL expressionGrowth factorRegulation of FasLApoptotic signalingTranslation levelsFas ligand expressionWestern blot analysisEndothelial growth factorFas receptorFasL levelsBlot analysisFas ligandExpression of FasLConcentration-dependent mannerMitogenic cytokinesEffects of VEGFRegulationExpressionParacrine manner
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisInterleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma
Senturk L, Sozen I, Gutierrez L, Arici A. Interleukin 8 production and interleukin 8 receptor expression in human myometrium and leiomyoma. American Journal Of Obstetrics And Gynecology 2001, 184: 559-566. PMID: 11262453, DOI: 10.1067/mob.2001.111160.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, NorthernCell DivisionDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayFemaleGonadotropin-Releasing HormoneHumansImmunohistochemistryInterleukin-1Interleukin-8KineticsLeiomyomaMyometriumReceptors, Interleukin-8ARNA, MessengerTumor Cells, CulturedTumor Necrosis Factor-alphaUterine NeoplasmsConceptsInterleukin-8 productionTumor necrosis factor alphaNecrosis factor alphaInterleukin-8Factor alphaInterleukin-1alphaMyometrial cellsCell proliferationInterleukin-8 receptor expressionGonadotropin-releasing hormone agonistType APotent chemoattractant cytokinesDose-dependent increaseMyometrial cell proliferationMessenger ribonucleic acid expressionDose-dependent inhibitionEnzyme-linked immunosorbentRibonucleic acid expressionLeiomyomatous tissueLeiomyomatous uterusHormone agonistHuman myometriumReceptor expressionChemoattractant cytokinesMyometrial tissue
2000
Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation
Arici A, Sozen I. Transforming growth factor-β3 is expressed at high levels in leiomyoma where it stimulates fibronectin expression and cell proliferation. Fertility And Sterility 2000, 73: 1006-1011. PMID: 10785229, DOI: 10.1016/s0015-0282(00)00418-0.Peer-Reviewed Original ResearchConceptsTGF-beta3 mRNA levelsLeiomyoma cell proliferationCell proliferationLeiomyoma cellsFibronectin expressionMRNA levelsLeiomyoma samplesProliferative phase samplesTGF-beta3 mRNAUniversity Medical CenterFibronectin mRNA expressionExpression of fibronectinMedical CenterFibrogenic processMAIN OUTCOMESex steroidsMidsecretory phaseMyometrial cellsMyometrial samplesLeiomyomaTGF-beta3MRNA expressionGrowth-promoting effectMyometriumGrowth factor β3
1999
Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1
Arici A, Senturk L, Seli E, Bahtiyar M, Kim G. Regulation of Monocyte Chemotactic Protein-1 Expression in Human Endometrial Stromal Cells by Estrogen and Progesterone1. Biology Of Reproduction 1999, 61: 85-90. PMID: 10377035, DOI: 10.1095/biolreprod61.1.85.Peer-Reviewed Original ResearchConceptsMCP-1 expressionEndometrial stromal cellsHuman endometrial stromal cellsMCP-1 levelsStromal cellsMacrophage migrationEstrogen levelsMCP-1 protein productionMonocyte chemotactic protein-1 expressionMCP-1 mRNA levelsChemotactic protein-1 expressionChemotactic protein-1Combination of E2Steroid hormone levelsProtein-1 expressionConcentration-dependent mannerEndometrial macrophagesMCP-1E2 treatmentHormone levelsSex steroidsEstradiol-17betaProgesteroneMRNA levelsProtein 1Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model
Zeyneloglu H, Seli E, Senturk L, Gutierrez L, Olive D, Arici A. The effect of monocyte chemotactic protein 1 in intraperitoneal adhesion formation in a mouse model. American Journal Of Obstetrics And Gynecology 1998, 179: 438-443. PMID: 9731850, DOI: 10.1016/s0002-9378(98)70376-x.Peer-Reviewed Original ResearchExpression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata
Sozen I, Olive D, Arici A. Expression and Hormonal Regulation of Monocyte Chemotactic Protein-1 in Myometrium and Leiomyomata. Fertility And Sterility 1998, 69: 1095-1102. PMID: 9627299, DOI: 10.1016/s0015-0282(98)00072-7.Peer-Reviewed Original ResearchConceptsMCP-1 mRNA levelsChemotactic protein-1MCP-1Leiomyoma cellsSex steroidsHigher MCP-1 levelsSteroid hormonesMCP-1 protein productionMonocyte chemotactic protein-1MCP-1 levelsMRNA levelsProtein 1Proliferative phase samplesImmunoreactive MCP-1MCP-1 expressionUniversity Medical CenterLeiomyoma cell proliferationParacrine growth factorMCP-1 mRNAGrowth stimulatory effectMessenger RNA levelsPathogenesis of leiomyomaLocal immunityGnRH analoguesProspective studyInterleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cells
1997
Growth‐Regulated α Expression in Human Preovulatory Follicles and Ovarian Cells
Oral E, Seli E, Bahtiyar M, Jones E, Arici A. Growth‐Regulated α Expression in Human Preovulatory Follicles and Ovarian Cells. American Journal Of Reproductive Immunology 1997, 38: 19-25. PMID: 9266006, DOI: 10.1111/j.1600-0897.1997.tb00271.x.Peer-Reviewed Original ResearchConceptsGRO-alpha levelsGranulosa-lutein cellsGRO-alpha productionGRO alphaFollicular fluidGRO-alpha mRNAAlpha productionPg/Stromal cellsAlpha levelsAlpha mRNAHuman preovulatory folliclesOvarian stromal cellsPeriovulatory follicular fluidProcess of ovulationTime of ovulationInterleukin-alphaTumor necrosisNeutrophil chemotaxisNeutrophil increaseΑ expressionPreovulatory folliclesGranulosa-luteinOvarian cellsPost-hCGMonocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells
Arici A, Oral E, Attar E, Tazuke S, Olive D. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertility And Sterility 1997, 67: 1065-1072. PMID: 9176445, DOI: 10.1016/s0015-0282(97)81440-9.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1Chemotactic protein-1 levelsChemotactic protein-1Protein-1 levelsChemotactic protein-1 concentrationsProtein-1 concentrationsPeritoneal fluidMesothelial cellsPg/Severe endometriosisProtein 1Control womenSecretory phaseProliferative phaseSevere endometriosis groupPathogenesis of endometriosisPeritoneal mesothelial cellsInterleukin-1 alphaUniversity Medical CenterMessenger RNA expressionUntreated endometriosisGnRH agonistEndometriosis groupModerate endometriosisProspective studyMonocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells
Arici A, Oral E, Bukulmez O, Buradagunta S, Bahtiyar O, Jones E. Monocyte chemotactic protein-1 expression in human preovulatory follicles and ovarian cells. Journal Of Reproductive Immunology 1997, 32: 201-219. PMID: 9080384, DOI: 10.1016/s0165-0378(97)82476-x.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1MCP-1 levelsFollicular fluidHCG administrationPreovulatory folliclesPg/Granulosa-lutein cell culturesSerum MCP-1 levelsMacrophage migrationMCP-1 mRNA expressionChemotactic protein-1 expressionAdministration of hCGHuman preovulatory folliclesSerum progesterone levelsChemotactic protein-1Human ovarian folliclesFollicular fluid samplesHuman follicular fluidGranulosa-lutein cellsLH/hCGInterleukin-1 alphaMonocytes/macrophagesProtein-1 expressionMCP-1 mRNAPg/mL
1996
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube
Keltz M, Attar E, Buradagunta S, Olive D, Kliman H, Arici A. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in the human fallopian tube. American Journal Of Obstetrics And Gynecology 1996, 175: 1611-1619. PMID: 8987949, DOI: 10.1016/s0002-9378(96)70114-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood Physiological PhenomenaCells, CulturedCulture MediaCytokinesEpitheliumFallopian TubesFemaleGene Expression RegulationGrowth InhibitorsGrowth SubstancesHormonesHumansInterleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPregnancyPregnancy, EctopicRNA, MessengerStromal CellsConceptsLeukemia inhibitory factor expressionLeukemia inhibitory factorFallopian tubeInhibitory factorStromal cellsEctopic pregnancyStromal cell culturesGrowth factorMessenger ribonucleic acidLeukemia inhibitory factor gene expressionEctopic implantationFactor expressionTubal ectopic pregnancyEpithelial cellsInterleukin-1 alphaHuman fallopian tubePlatelet-derived growth factorMessenger ribonucleic acid levelsRibonucleic acid levelsFactor gene expressionTubal mucosaMenstrual cycleTNF-alphaTumor necrosisCommon siteModulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1
Arici A, MacDonald P, Casey M. Modulation of the levels of interleukin-8 messenger ribonucleic acid and interleukin-8 protein synthesis in human endometrial stromal cells by transforming growth factor-beta 1. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 3004-3009. PMID: 8768866, DOI: 10.1210/jcem.81.8.8768866.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidEndometrial stromal cellsHuman endometrial stromal cellsMessenger ribonucleic acidIL-8TGF beta 1Stromal cellsChemotactic factorsInterleukin-8 messenger ribonucleic acidT-cell chemotactic factorBone marrow-derived cellsBeta 1Ovarian steroid secretionTGF beta 1 treatmentImmunoreactive IL-8Marrow-derived cellsEndometrium/deciduaInterleukin-8 gene expressionIL-8 geneParacrine-acting factorsOvulatory womenEndometrial decidualizationEndometrial stromaSteroid secretionLeukocyte populationsPeritoneal Growth Factors and Endometriosis
Oral E, Arici A. Peritoneal Growth Factors and Endometriosis. Seminars In Reproductive Medicine 1996, 14: 257-267. PMID: 8885056, DOI: 10.1055/s-2007-1016335.Peer-Reviewed Original ResearchProgestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells
Arici A, MacDonald P, Casey M. Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells. The Journal Of Steroid Biochemistry And Molecular Biology 1996, 58: 71-76. PMID: 8809187, DOI: 10.1016/0960-0760(96)00016-7.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDactinomycinEndometriumFemaleGene Expression RegulationHumansInterleukin-1Interleukin-8Medroxyprogesterone AcetateMolecular Sequence DataProgesteroneProgesterone CongenersProgestinsProtein Synthesis InhibitorsRecombinant ProteinsRNA, MessengerStromal CellsTranscription, GeneticConceptsIL-8 mRNAHuman endometrial stromal cellsEndometrial stromal cellsInterleukin-8IL-1Stromal cellsInterleukin-8 mRNA levelsNormal human pregnancyIL-8 gene transcriptionFormation of cytokinesMigration of leukocytesConcentration-dependent mannerEndometrial repairHuman pregnancyLeukocytic infiltrationDecidual tissuesHuman endometriumT cellsProgestin regulationSynthetic progestinsUterine endometriumUterine involutionHormonal eventsOvarian cycleEndometriumModulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1
Arici A, MacDonald P, Casey M. Modulation of the Levels of Transforming Growth Factor β Messenger Ribonucleic Acids in Human Endometrial Stromal Cells1. Biology Of Reproduction 1996, 54: 463-469. PMID: 8788200, DOI: 10.1095/biolreprod54.2.463.Peer-Reviewed Original ResearchConceptsTGF beta 3 mRNAEndometrial stromal cellsTGF beta 1 mRNATGF beta 1Beta 3 mRNAHuman endometrial stromal cellsBeta 1 mRNAPlatelet-derived growth factorStromal cellsBeta 1Proliferative phase endometrial tissueTGF beta 2 mRNATGF-beta mRNA levelsGrowth factorTGF beta 1 treatmentProliferative phase endometriumEstradiol-17 betaLate secretory phaseSecretory phase tissuesBeta 2 mRNABeta mRNA levelsGrowth factor betaDose-dependent mannerTotal RNATime-dependent fashion
1995
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium
Arici A, Engin O, Attar E, Olive D. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 1908-1915. PMID: 7775640, DOI: 10.1210/jcem.80.6.7775640.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodCells, CulturedCulture MediaDeciduaEndometriumEpidermal Growth FactorFemaleGene Expression RegulationGrowth InhibitorsHumansInterferon-gammaInterleukin-1Interleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPlatelet-Derived Growth FactorPregnancyProtein BiosynthesisRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaConceptsExpression of LIFLeukemia inhibitory factorLIF expressionLIF mRNAEndometrial cellsGrowth factorHuman endometriumLeukemia inhibitory factor gene expressionMenstrual cycle-dependent mannerRole of LIFSteroid hormonesHuman implantationLIF mRNA expressionEndometrial stromal cellsEndometrium/deciduaHuman endometrial cellsPlatelet-derived growth factorEndometrial gland cellsMessenger ribonucleic acid levelsRibonucleic acid levelsMidluteal endometriumFactor gene expressionTime-dependent mannerFirst trimesterTumor necrosisRegulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures
Arici A, MacDonald P, Casey M. Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures. Molecular And Cellular Endocrinology 1995, 107: 189-197. PMID: 7768330, DOI: 10.1016/0303-7207(94)03442-v.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedChemokine CCL2Chemotactic FactorsCulture MediaDeciduaDNA PrimersEndometriumEpithelial CellsEpitheliumFemaleGene Expression RegulationHalf-LifeHumansInterleukin-1Menstrual CycleMolecular Sequence DataPlatelet-Derived Growth FactorPregnancyRNA, MessengerTranscription, GeneticTumor Necrosis Factor-alphaConceptsMCP-1 mRNAMonocyte chemotactic protein-1Endometrial stromal cellsEndometrium/deciduaStromal cellsBone marrow-derived leukocytesHuman endometrial stromal cellsEpithelial cellsChemotactic protein-1 gene expressionDuration of pregnancyChemotactic protein-1Human endometrial tissueMonocyte chemotactic protein-1 gene expressionHuman endometrial cellsHuman endometrium/deciduaDay of cycleProtein-1 gene expressionTotal RNAMacrophage chemotacticTypes of leukocytesEndometrial tissueHormonal milieuDecidua parietalisEndometrial cellsHuman endometrium