2004
Endometriosis and Inflammation in Infertility
HALIS G, ARICI A. Endometriosis and Inflammation in Infertility. Annals Of The New York Academy Of Sciences 2004, 1034: 300-315. PMID: 15731321, DOI: 10.1196/annals.1335.032.Peer-Reviewed Original ResearchConceptsPeritoneal fluidEndometriosis-associated inflammationTubal factor infertilityRate of womenReproductive failureProinflammatory mediatorsFactor infertilityInflammatory factorsPregnancy rateEndometriosisAdvanced stageAngiogenic factorsConfounding factorsInflammationGrowth factorInfertilityWomenReproductive technologiesRecent dataRecent reportsReproductive organsElevated amountsAspects of reproductionFactorsFailure
2000
Implantation defect in endometriosis: endometrium or peritoneal fluid.
Selam B, Arici A. Implantation defect in endometriosis: endometrium or peritoneal fluid. Society Of Reproduction And Fertility 2000, 55: 121-8. PMID: 10889841.Peer-Reviewed Original ResearchConceptsEndometrial receptivityPeritoneal environmentRole of alterationsCytokine concentrationsPeritoneal fluidCell adhesion moleculeEndometriosisClinical observationsHormone analogueDirect actionAdhesion moleculesIron metabolismBiochemical factorsImplantation defectsImplantationWomenRecent studiesFluid microenvironmentPossible mechanismReceptivityEndometriumGonadotrophinDerangement
1999
The relevance of the peritoneal fluid in endometriosis-associated infertility
Mulayim N, Arici A. The relevance of the peritoneal fluid in endometriosis-associated infertility. Human Reproduction 1999, 14: 67-76. PMID: 10690802, DOI: 10.1093/humrep/14.suppl_2.67.Peer-Reviewed Original ResearchConceptsPeritoneal fluidEndometriosis-associated infertilityPathogenesis of endometriosisOccurrence of endometriosisImmunological factorsEndometriotic lesionsFertile womenGynaecological disordersEndometriosisEarly reproductive eventsHeterogenous symptomsImmunological differencesSteps of reproductionReproductive failureDiseaseRecent studiesClear conclusionsReproductive eventsInfertilityPathogenesisLesionsSymptomsWomenMacrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populationsChemokines and human reproduction
Garcı́a-Velasco J, Arici A. Chemokines and human reproduction. Fertility And Sterility 1999, 71: 983-993. PMID: 10360897, DOI: 10.1016/s0015-0282(99)00120-x.Peer-Reviewed Original ResearchConceptsChemotactic protein-1Interleukin-8Preterm laborCervical ripeningMonocyte chemotactic protein-1Endometrial stromal cell growthRole of chemokinesProtein 1Corpus luteum functionInterleukin-8 correlatesNew therapeutic strategiesAutocrine growth factorHuman reproductionStromal cell growthRelease of collagenaseExtracellular matrix remodelingPeritoneal fluidVillous placentaChemotactic cytokinesHuman endometriumMEDLINE searchFollicular developmentTherapeutic strategiesLeukocyte trafficChemokines
1998
Recent advances in endometriosis
Arici A, Pehlivan T. Recent advances in endometriosis. Current Opinion In Endocrinology Diabetes And Obesity 1998, 5: 330-340. DOI: 10.1097/00060793-199811000-00015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritoneal fluidMaximal pain reliefEndometriosis-associated infertilityEffect of endometriosisChemoattractant protein-1Pathogenesis of endometriosisPain reliefPelvic painIL-10Pathophysiologic mechanismsTreatment optionsEctopic endometriumIL-13Endometrial cellsReproductive outcomesAromatase expressionMild lesionsSide effectsFertility outcomesMatrix metalloproteinasesEndometriosisPeritoneal macrophagesApoptosis markersIntegrin expressionProtein 1Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development
Seli E, Zeyneloglu H, Senturk L, Bahtiyar O, Olive D, Arici A. Basic Fibroblast Growth Factor: Peritoneal and Follicular Fluid Levels and its Effect on Early Embryonic Development. Fertility And Sterility 1998, 69: 1145-1148. PMID: 9627307, DOI: 10.1016/s0015-0282(98)00074-0.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorFibroblast growth factorPeritoneal fluidFollicular fluidBasic FGF levelsFollicular fluid levelsPresence of endometriosisFGF levelsBlastocyst formationException of ageOvulation inductionProspective studyMenstrual cycleMAIN OUTCOMEFluid levelsEndometriosisMurine preimplantation embryonic developmentGrowth factorFGF concentrationsPreimplantation embryonic developmentWomenTwo-cell murine embryosPreimplantation embryosEmbryonic developmentReproductive parametersThe Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis
Zeyneloglu H, Senturk L, Seli E, Bahtiyar O, Olive D, Arici A. The Peritoneal Fluid Levels of Interleukin‐12 in Women with Endometriosis. American Journal Of Reproductive Immunology 1998, 39: 152-156. PMID: 9506213, DOI: 10.1111/j.1600-0897.1998.tb00347.x.Peer-Reviewed Original ResearchConceptsPeritoneal fluid levelsIL-12Peritoneal fluidMesothelial cell culturesInterleukin-12Fluid levelsPg/High-sensitivity enzyme-linked immunosorbentNatural killer cell activityKiller cell activityIL-12 levelsPresence of endometriosisNatural killer cellsPeritoneal fluid samplesMonocytes/macrophagesEnzyme-linked immunosorbentKiller cellsT cellsEndometriosisCell culturesCell activityWomenFluid samplesSignificant differencesStromal
1997
Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells
Arici A, Oral E, Attar E, Tazuke S, Olive D. Monocyte chemotactic protein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertility And Sterility 1997, 67: 1065-1072. PMID: 9176445, DOI: 10.1016/s0015-0282(97)81440-9.Peer-Reviewed Original ResearchConceptsMonocyte chemotactic protein-1Chemotactic protein-1 levelsChemotactic protein-1Protein-1 levelsChemotactic protein-1 concentrationsProtein-1 concentrationsPeritoneal fluidMesothelial cellsPg/Severe endometriosisProtein 1Control womenSecretory phaseProliferative phaseSevere endometriosis groupPathogenesis of endometriosisPeritoneal mesothelial cellsInterleukin-1 alphaUniversity Medical CenterMessenger RNA expressionUntreated endometriosisGnRH agonistEndometriosis groupModerate endometriosisProspective study
1996
Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components**Supported by grants HD-19505 and HD-32902 (to G.H.) from the National Institutes of Health, Bethesda, Maryland.
Oral E, Arici A, Olive D, Huszar G. Peritoneal fluid from women with moderate or severe endometriosis inhibits sperm motility: the role of seminal fluid components**Supported by grants HD-19505 and HD-32902 (to G.H.) from the National Institutes of Health, Bethesda, Maryland. Fertility And Sterility 1996, 66: 787-792. PMID: 8893686, DOI: 10.1016/s0015-0282(16)58637-3.Peer-Reviewed Original ResearchConceptsPeritoneal fluidSperm motilityCell-mediated inhibitionT-testStudent's t-testRandomized studyRelated infertilitySevere endometriosisMild endometriosisFertile womenSeminal fluidMAIN OUTCOMEEndometriosisSperm fractionSperm motility inhibitionLeukocyte componentsInhibitory actionSemen analysisPhysiological salineProgressive motile spermWomenNational InstituteAndrology laboratoryOvernight incubationMotility inhibitionThe peritoneal environment in endometriosis
Oral E, Olive D, Arici A. The peritoneal environment in endometriosis. Human Reproduction Update 1996, 2: 385-398. PMID: 15717438, DOI: 10.1093/humupd/2.5.385.Peer-Reviewed Original ResearchConceptsPeritoneal fluidPeritoneal environmentPF of womenEtiology of endometriosisMonocytes/macrophagesSpermatozoon-oocyte interactionEndometriotic implantsEndometrial fragmentsPeritoneal factorsPeritoneal endometriosisRetrograde menstruationIL-8MCP-1Postimplantation survivalChemoattractant cytokinesMast cellsEndometriosisImmune systemMesothelial cellsCytokinesGrowth factorOvum captureMacrophagesEtiologyCell types