2006
P-380 Expression and regulation of integrin-linked kinase in human endometrium throughout the menstrual cycle and early pregnancy
Kim S, Yen C, Atabekoglu C, Cakmak H, Arici A, Kayisli U. P-380 Expression and regulation of integrin-linked kinase in human endometrium throughout the menstrual cycle and early pregnancy. Fertility And Sterility 2006, 86: s276-s277. DOI: 10.1016/j.fertnstert.2006.07.737.Peer-Reviewed Original Research
2004
Endocrine‐Immune Interactions in Human Endometrium
KAYISLI UA, GUZELOGLU‐KAYISLI O, ARICI A. Endocrine‐Immune Interactions in Human Endometrium. Annals Of The New York Academy Of Sciences 2004, 1034: 50-63. PMID: 15731299, DOI: 10.1196/annals.1335.005.Peer-Reviewed Original ResearchConceptsProtein kinase BEndocrine-immune interactionsHuman endometriumBalanced regulationKinase BCell survivalImmune systemMolecular pathwaysApoptotic moleculesSurvival factorProgression of pregnancyWidespread associationReproductive systemTissue repairIndirect roleMenstrual bleedingApoptosisEndometrial cellsEndometrial differentiationNonresident cellsChemotactic cytokinesLeukocyte recruitmentSex steroidsBlastocyst implantationRegulationThe effect of sex steriods on IL-8 and MCP-1 expression in human endometrial endothelial cells − The gatekeeper of human endometrium
Luk J, Seval Y, Kayisli U, Arici A. The effect of sex steriods on IL-8 and MCP-1 expression in human endometrial endothelial cells − The gatekeeper of human endometrium. Fertility And Sterility 2004, 82: s62. DOI: 10.1016/j.fertnstert.2004.07.158.Peer-Reviewed Original Research
2002
Expression of PTEN in human endometrium throughout the menstrual cycle and during early pregnancy and its regulation by progesterone
Kayisli U, Guzelolgu-Kayisli O, Berkkanoglu M, Arici A. Expression of PTEN in human endometrium throughout the menstrual cycle and during early pregnancy and its regulation by progesterone. Fertility And Sterility 2002, 78: s168. DOI: 10.1016/s0015-0282(02)03839-6.Peer-Reviewed Original Research
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisExpression of aminopeptidase N in human endometrium and regulation of its activity by estrogen
Seli E, Senturk L, Bahtiyar O, Kayisli U, Arici A. Expression of aminopeptidase N in human endometrium and regulation of its activity by estrogen. Fertility And Sterility 2001, 75: 1172-1176. PMID: 11384645, DOI: 10.1016/s0015-0282(01)01779-4.Peer-Reviewed Original ResearchConceptsExpression of APNEarly proliferative phaseMenstrual cycleInterleukin-8Human endometriumProliferative phaseCultured endometrial stromal cellsEndometrial stromal cell culturesEndometrial stromal cellsUniversity Medical CenterPolymorphonuclear leukocyte chemotaxisAPN activityAminopeptidase NConcentration-dependent mannerEndometrial pathologyEndometrial stromaProspective studyStromal cell culturesEndometrial sectionsAPN antibodyMedical CenterMAIN OUTCOMESex steroidsSecretory phaseEndometrium
1999
Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalChemokines and human reproduction
Garcı́a-Velasco J, Arici A. Chemokines and human reproduction. Fertility And Sterility 1999, 71: 983-993. PMID: 10360897, DOI: 10.1016/s0015-0282(99)00120-x.Peer-Reviewed Original ResearchConceptsChemotactic protein-1Interleukin-8Preterm laborCervical ripeningMonocyte chemotactic protein-1Endometrial stromal cell growthRole of chemokinesProtein 1Corpus luteum functionInterleukin-8 correlatesNew therapeutic strategiesAutocrine growth factorHuman reproductionStromal cell growthRelease of collagenaseExtracellular matrix remodelingPeritoneal fluidVillous placentaChemotactic cytokinesHuman endometriumMEDLINE searchFollicular developmentTherapeutic strategiesLeukocyte trafficChemokinesSex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1
Taylor H, Igarashi P, Olive D, Arici A. Sex Steroids Mediate HOXA11 Expression in the Human Peri-Implantation Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 1129-1135. PMID: 10084606, DOI: 10.1210/jcem.84.3.5573.Peer-Reviewed Original ResearchConceptsHuman endometriumEndometrial developmentSex steroidsHuman endometrial developmentPeri-implantation endometriumMaintenance of pregnancyDose-responsive increaseAdult human endometriumTime of implantationMessenger RNA levelsProgesterone concentrationsEndometriumHOXA11 expressionPhysiologic rangeRNA levelsSteroidsPotential rolePregnancyImplantationEstrogenHOXA11ExpressionGene expressionSequential developmentNorthern analysis
1998
Interleukin-8 in the Human Endometrium1
Arici A, Seli E, Senturk L, Gutierrez L, Oral E, Taylor H. Interleukin-8 in the Human Endometrium1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1783-1787. PMID: 9589693, DOI: 10.1210/jcem.83.5.4754.Peer-Reviewed Original ResearchConceptsIL-8 messenger ribonucleic acidInterleukin-8Menstrual cycleMessenger ribonucleic acidHuman endometriumMenstrual historyT cell chemotactic activityIL-8 mRNA levelsWoman's menstrual historyImmunoreactive IL-8IL-8 antibodyIL-8 expressionIL-8 proteinEndometrial biopsyEndometrial diseaseEndometrial tissueSex hormonesHuman uterusSurface epitheliumChemotactic activityEndometriumFrozen sectionsStromal cellsLate secretoryGlandular cellsHOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
Taylor H, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Journal Of Clinical Investigation 1998, 101: 1379-1384. DOI: 10.1172/jci1057.Peer-Reviewed Original ResearchExpression of HOXA10Menstrual cycleTime of implantationSex steroidsCultured endometrial cellsUterine factor infertilityEffects of estrogenFactor infertilityEndometrial developmentEndometrial cellsHuman endometriumMidsecretory phaseHuman uterusPhysiologic rangeProgesteroneHOXA10Targeted disruptionNorthern blot analysisBlot analysisEstrogenSteroidsImplantationSitu hybridizationNovel regulatorExpressionLeukemia Inhibitory Factor in Human Reproduction
Senturk L, Arici A. Leukemia Inhibitory Factor in Human Reproduction. American Journal Of Reproductive Immunology 1998, 39: 144-151. PMID: 9506212, DOI: 10.1111/j.1600-0897.1998.tb00346.x.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorFallopian tubeMenstrual cycleHuman endometriumMenstrual cycle-dependent mannerInhibitory factorRole of LIFEffects of LIFHuman reproductionEndometrial LIF expressionMyeloid leukemic cell linesTime of implantationTime of ovulationLIF levelsOvulatory eventsLIF expressionInterleukin-6 familyStromal cell culturesEndometrial tissueInflammatory cytokinesLeukemic cell linesPeripheral neuronsPleiotropic cytokineSuccessful implantationOvarian follicles
1996
Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells
Arici A, MacDonald P, Casey M. Progestin regulation of interleukin-8 mRNA levels and protein synthesis in human endometrial stromal cells. The Journal Of Steroid Biochemistry And Molecular Biology 1996, 58: 71-76. PMID: 8809187, DOI: 10.1016/0960-0760(96)00016-7.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedDactinomycinEndometriumFemaleGene Expression RegulationHumansInterleukin-1Interleukin-8Medroxyprogesterone AcetateMolecular Sequence DataProgesteroneProgesterone CongenersProgestinsProtein Synthesis InhibitorsRecombinant ProteinsRNA, MessengerStromal CellsTranscription, GeneticConceptsIL-8 mRNAHuman endometrial stromal cellsEndometrial stromal cellsInterleukin-8IL-1Stromal cellsInterleukin-8 mRNA levelsNormal human pregnancyIL-8 gene transcriptionFormation of cytokinesMigration of leukocytesConcentration-dependent mannerEndometrial repairHuman pregnancyLeukocytic infiltrationDecidual tissuesHuman endometriumT cellsProgestin regulationSynthetic progestinsUterine endometriumUterine involutionHormonal eventsOvarian cycleEndometrium
1995
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium
Arici A, Engin O, Attar E, Olive D. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 1908-1915. PMID: 7775640, DOI: 10.1210/jcem.80.6.7775640.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodCells, CulturedCulture MediaDeciduaEndometriumEpidermal Growth FactorFemaleGene Expression RegulationGrowth InhibitorsHumansInterferon-gammaInterleukin-1Interleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPlatelet-Derived Growth FactorPregnancyProtein BiosynthesisRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaConceptsExpression of LIFLeukemia inhibitory factorLIF expressionLIF mRNAEndometrial cellsGrowth factorHuman endometriumLeukemia inhibitory factor gene expressionMenstrual cycle-dependent mannerRole of LIFSteroid hormonesHuman implantationLIF mRNA expressionEndometrial stromal cellsEndometrium/deciduaHuman endometrial cellsPlatelet-derived growth factorEndometrial gland cellsMessenger ribonucleic acid levelsRibonucleic acid levelsMidluteal endometriumFactor gene expressionTime-dependent mannerFirst trimesterTumor necrosisRegulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures
Arici A, MacDonald P, Casey M. Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures. Molecular And Cellular Endocrinology 1995, 107: 189-197. PMID: 7768330, DOI: 10.1016/0303-7207(94)03442-v.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedChemokine CCL2Chemotactic FactorsCulture MediaDeciduaDNA PrimersEndometriumEpithelial CellsEpitheliumFemaleGene Expression RegulationHalf-LifeHumansInterleukin-1Menstrual CycleMolecular Sequence DataPlatelet-Derived Growth FactorPregnancyRNA, MessengerTranscription, GeneticTumor Necrosis Factor-alphaConceptsMCP-1 mRNAMonocyte chemotactic protein-1Endometrial stromal cellsEndometrium/deciduaStromal cellsBone marrow-derived leukocytesHuman endometrial stromal cellsEpithelial cellsChemotactic protein-1 gene expressionDuration of pregnancyChemotactic protein-1Human endometrial tissueMonocyte chemotactic protein-1 gene expressionHuman endometrial cellsHuman endometrium/deciduaDay of cycleProtein-1 gene expressionTotal RNAMacrophage chemotacticTypes of leukocytesEndometrial tissueHormonal milieuDecidua parietalisEndometrial cellsHuman endometrium
1994
Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells
Marshburn P, Arici A, Casey M. Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells. American Journal Of Obstetrics And Gynecology 1994, 170: 1152-1158. PMID: 8166201, DOI: 10.1016/s0002-9378(94)70112-1.Peer-Reviewed Original ResearchConceptsEstradiol-17 betaEndometrial stromal cellsEndometrial glandsMessenger ribonucleic acidStromal cellsHuman endometriumDeoxyribonucleic acid synthesisGlandular epitheliumEpithelial cellsEndometrial glandular epitheliumEndometrial cell proliferationStromal cell originHuman endometrial cellsGrowth factor-β1Acid synthesisRibonucleic acidSecretory endometriumEndometrial cellsTrichloroacetic acid-precipitable materialEndometrial epitheliumSecretory phaseFactor-β1Cell originAcid-precipitable materialEndometrium
1993
Regulation of interleukin-8 gene expression in human endometrial cells in culture
Arici A, Head J, MacDonald P, Casey M. Regulation of interleukin-8 gene expression in human endometrial cells in culture. Molecular And Cellular Endocrinology 1993, 94: 195-204. PMID: 8224523, DOI: 10.1016/0303-7207(93)90168-j.Peer-Reviewed Original ResearchConceptsIL-8 mRNAEndometrial stromal cellsIL-1 alphaInterleukin-8 gene expressionEndometrial epithelial cellsStromal cellsEpithelial cellsIL-8 mRNA levelsImmunoreactive IL-8IL-8 gene expressionIL-8 gene transcriptionHuman endometrial cellsRecruitment of leukocytesIL-1 treatmentConcentration-dependent mannerIL-8Endometrial cellsTumor necrosisHuman endometriumGene expressionIL-1Glandular epitheliumSerum-free mediumSerum treatmentPresence of serum