2020
CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking
Pluchino N, Mamillapalli R, Shaikh S, Habata S, Tal A, Gaye M, Taylor HS. CXCR4 or CXCR7 antagonists treat endometriosis by reducing bone marrow cell trafficking. Journal Of Cellular And Molecular Medicine 2020, 24: 2464-2474. PMID: 31904910, PMCID: PMC7028867, DOI: 10.1111/jcmm.14933.Peer-Reviewed Original ResearchConceptsCXCR7 antagonistLesion sizePro-inflammatory cytokine productionBone marrow-derived cellsNon-hormonal therapiesMouse bone marrow transplantation modelBone marrow transplantation modelBone marrow cell migrationMarrow-derived cellsProgression of endometriosisEndometriosis implantsEndometrial effectsAntagonist treatmentEndometriotic lesionsCytokine productionEndometrial physiologyStem cell recruitmentEutopic endometriumTransplantation modelCell recruitmentNull miceCell traffickingEndometriosisEpithelial cell fateCXCR4
2019
Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy
Tal R, Shaikh S, Pallavi P, Tal A, López-Giráldez F, Lyu F, Fang YY, Chinchanikar S, Liu Y, Kliman HJ, Alderman M, Pluchino N, Kayani J, Mamillapalli R, Krause DS, Taylor HS. Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy. PLOS Biology 2019, 17: e3000421. PMID: 31513564, PMCID: PMC6742226, DOI: 10.1371/journal.pbio.3000421.Peer-Reviewed Original ResearchConceptsBM transplantsDecidual cellsPregnancy lossMesenchymal stem cellsAdult bone marrow progenitorsDecidualization-related genesBone marrow progenitorsAdult bone marrowWT donorsPhysiologic contributionSuccessful pregnancyBMDC recruitmentStromal expansionImmune cellsEndometrial cellsDeficient miceUterine expressionUterine tissueDecidual stromaPregnancyBone marrowNonhematopoietic cellsBMDCsHemochorial placentaMarrow progenitorsEndometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†
Tal A, Tal R, Pluchino N, Taylor HS. Endometrial cells contribute to preexisting endometriosis lesions in a mouse model of retrograde menstruation†. Biology Of Reproduction 2019, 100: 1453-1460. PMID: 30869747, PMCID: PMC6561859, DOI: 10.1093/biolre/ioz039.Peer-Reviewed Original ResearchConceptsRetrograde menstruationUterine cellsEndometrial tissueEndometriosis lesionsEndometrial cellsAdverse clinical manifestationsChronic pelvic painPathophysiology of endometriosisProgression of endometriosisC57BL/6J female miceNonhuman primate modelEndometrial tissue fragmentsEndometriotic processPelvic painClinical manifestationsEndometriotic lesionsInflammatory processIntraperitoneal injectionFemale micePrimate modelExtrauterine growthPeritoneal cavityEndometriosisMouse modelLesions
2018
Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis
Li F, Alderman MH, Tal A, Mamillapalli R, Coolidge A, Hufnagel D, Wang Z, Neisani E, Gidicsin S, Krikun G, Taylor HS. Hematogenous Dissemination of Mesenchymal Stem Cells from Endometriosis. Stem Cells 2018, 36: 881-890. PMID: 29450941, PMCID: PMC5992028, DOI: 10.1002/stem.2804.Peer-Reviewed Original ResearchConceptsSerum CXCL12 levelsCXCL12 levelsEndometrial tissueEndometriosis lesionsHematogenous disseminationMesenchymal stem cell biomarkersCXCL12/CXCR4 axisStem cellsTreatment of endometriosisSham control miceEndometrial stem cellsHematopoietic stem cell markersStem cell biomarkersStem cell markersSpontaneous endometriosisRetrograde menstruationControl miceExperimental endometriosisRecipient miceCXCR4 axisLung tissueEndometriosisPeritoneal cavityDsRed miceBlood of animals