Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage
Leasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Woo D, Ziai WC, Hanley DF, Salman R, Matouk CC, Sansing LH, Sheth KN, Falcone GJ. Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage. JAMA Neurology 2019, 76: 949-955. PMID: 31081862, PMCID: PMC6515816, DOI: 10.1001/jamaneurol.2019.1141.Peer-Reviewed Original ResearchIntensive Blood Pressure ReductionDeep intracerebral hemorrhageBlood pressure reductionIntracerebral hemorrhageHematoma expansionStandard treatmentIntensive treatmentPressure reductionMAIN OUTCOMEModified Rankin scale score distributionIntensive blood pressure treatmentRankin Scale score distributionBasal ganglia intracerebral hemorrhageThalamic intracerebral hemorrhageBasal ganglia hemorrhageBlood pressure treatmentStandard treatment groupModified Rankin ScaleRankin Scale scorePrimary intracerebral hemorrhageAcute care settingStrong risk factorSpontaneous intracerebral hemorrhageDeep brain nucleiAntihypertensive treatmentIntensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral Hemorrhage
Leasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Walsh KB, Woo D, Shi FD, Huttner HB, Ziai WC, Hanley DF, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Intensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral Hemorrhage. Stroke 2019, 50: 2016-2022. PMID: 31272326, PMCID: PMC6646091, DOI: 10.1161/strokeaha.119.024838.Peer-Reviewed Original ResearchConceptsDeep intracerebral hemorrhageIntensive BP reductionBasal ganglia intracerebral hemorrhageBlood pressure reductionIntracerebral hemorrhageBP reductionPoor outcomeATACH-2Intensive Blood Pressure ReductionPressure reductionPerihematomal edema expansionSecondary brain injurySupratentorial intracerebral hemorrhagePerihematomal edema volumeSpontaneous intracerebral hemorrhageRelevant end pointsDeep locationBaseline characteristicsEdema volumeBasal gangliaBrain injuryClinical trialsTomography scanEdema expansionTreatment groups