2021
Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms
Hamouda AK, Bautista MR, Akinola LS, Alkhlaif Y, Jackson A, Carper M, Toma WB, Garai S, Chen YC, Thakur GA, Fowler CD, Damaj MI. Potentiation of (α4)2(β2)3, but not (α4)3(β2)2, nicotinic acetylcholine receptors reduces nicotine self-administration and withdrawal symptoms. Neuropharmacology 2021, 190: 108568. PMID: 33878302, PMCID: PMC8169606, DOI: 10.1016/j.neuropharm.2021.108568.Peer-Reviewed Original ResearchConceptsPositive allosteric modulatorsWithdrawal symptomsHypothermic effectMale miceAntinociceptive effectΑ4β2 nAChRsNicotine withdrawal-induced hyperalgesiaNAChR isoformsNicotine's antinociceptive effectsWithdrawal-induced hyperalgesiaNicotine withdrawal symptomsNicotine addiction treatmentAnxiety-like behaviorNicotinic acetylcholine receptorsDose-dependent mannerNociceptive responsesNicotine withdrawalNicotine intakeSomatic signsNicotine abstinencePharmacological effectsNicotine useAcetylcholine receptorsAffective symptomsPathophysiological processes
2020
Differences in JUUL Appeal Among Past and Current Youth JUUL Users
Davis DR, Krishnan-Sarin S, Bold KW, Morean ME, Jackson A, Camenga D, Kong G. Differences in JUUL Appeal Among Past and Current Youth JUUL Users. Nicotine & Tobacco Research 2020, 23: 807-814. PMID: 33247938, PMCID: PMC8095239, DOI: 10.1093/ntr/ntaa246.Peer-Reviewed Original ResearchConceptsPharmacological effectsPast usersPositive pharmacological effectsCurrent usersE-cigarettesAdverse pharmacological effectsCross-sectional surveyPeer useLogistic regressionJUUL usersPrevention effortsUse statusNicotine contentCurrent useCurrent studyConnecticut high schoolsJUUL useJUULProduct characteristicsDifferences
2015
Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice
Alsharari SD, King JR, Nordman JC, Muldoon PP, Jackson A, Zhu AZ, Tyndale RF, Kabbani N, Damaj MI. Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. PLOS ONE 2015, 10: e0137070. PMID: 26355604, PMCID: PMC4565647, DOI: 10.1371/journal.pone.0137070.Peer-Reviewed Original ResearchConceptsNicotine pharmacokineticsSubunit expressionBrain regionsAcute pharmacological effectsNicotine-induced antinociceptionNicotine plasma levelsMale ICR miceStriatum of miceEffect of mentholSignificant increaseAddition of mentholAdministration of mentholWestern blot analysisChronic injectionsWithdrawal signsBrain levelsICR miceNicotine cigarettesPlasma levelsSystemic administrationNicotine clearanceNicotinic receptorsPharmacological effectsNicotinic subunitsCommon flavoring