Featured Publications
Auditory feature perception and auditory hallucinatory experiences in schizophrenia spectrum disorder
Schnakenberg Martin AM, Bartolomeo L, Howell J, Hetrick WP, Bolbecker AR, Breier A, Kidd G, O’Donnell B. Auditory feature perception and auditory hallucinatory experiences in schizophrenia spectrum disorder. European Archives Of Psychiatry And Clinical Neuroscience 2017, 268: 653-661. PMID: 28936548, PMCID: PMC7126185, DOI: 10.1007/s00406-017-0839-1.Peer-Reviewed Original ResearchConceptsAuditory verbal hallucinationsSchizophrenia spectrum disordersAuditory perceptionSZ individualsFeature perceptionVerbal hallucinationsSpectrum disorderAuditory featuresImpaired auditory perceptionSchizophrenia Voices QuestionnaireBasic Auditory CapabilitiesTemporal order discriminationAuditory hallucinatory experiencesCognitive processingTone taskOrder discriminationHamilton ProgramHallucinatory experiencesGreater deficitsSZ groupAuditory hallucinationsAuditory capabilitiesPerceptionVoice QuestionnaireIntellectual impairmentDifferential Cognitive Performance in Females and Males with Regular Cannabis Use
Martin A, D’Souza D, Newman SD, Hetrick WP, O’Donnell B. Differential Cognitive Performance in Females and Males with Regular Cannabis Use. Journal Of The International Neuropsychological Society 2021, 27: 570-580. PMID: 34261548, PMCID: PMC8830784, DOI: 10.1017/s1355617721000606.Peer-Reviewed Original ResearchConceptsRegular cannabis useCannabis useCognitive measuresPsychomotor speedBiological sexHopkins Verbal Learning TestDifferential cognitive performanceNon-using peersVerbal Learning TestMeasures of intelligenceWechsler Abbreviated ScaleDigit symbol testGreatest group differencesVerbal learningDigit spanLearning TestCognitive performanceAbbreviated ScaleNeurocognitive deficitsCognitive deficitsSymbol testCannabis exposurePsychomotor performanceGroup differencesCognition
2023
Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses
Schnakenberg Martin A, Flynn L, Sefik E, Luddy C, Cortes-Briones J, Skosnik P, Pittman B, Ranganathan M, D’Souza D. Preliminary study of the interactive effects of THC and ethanol on self-reported ability and simulated driving, subjective effects, and cardiovascular responses. Psychopharmacology 2023, 240: 1235-1246. PMID: 37045988, DOI: 10.1007/s00213-023-06356-0.Peer-Reviewed Original ResearchConceptsSubjective effectsOral tetrahydrocannabinolSelf-reported abilityEffects of cannabisInfluence of tetrahydrocannabinolCause of morbiditySimulated drivingFeeling statesBlood alcohol levelsMotor vehicle accidentsAlcohol-related motor vehicle accidentsCardiovascular responsesIntravenous ethanolHealthy humansHeart rateVehicle accidentsAlcohol levelsInteractive effectsTetrahydrocannabinolPhysiological effectsSignificant differencesDrivingAbilityPreliminary studyRationaleDrug
2022
The Relationship Between Cannabinoids and Neural Oscillations: How Cannabis Disrupts Sensation, Perception, and Cognition
Syed S, Martin A, Cortes-Briones J, Skosnik P. The Relationship Between Cannabinoids and Neural Oscillations: How Cannabis Disrupts Sensation, Perception, and Cognition. Clinical EEG And Neuroscience 2022, 54: 359-369. PMID: 36426543, DOI: 10.1177/15500594221138280.Peer-Reviewed Original ResearchConceptsNeural oscillationsNeural synchronyImportant clinical implicationsExcitatory balanceTheta frequency rangeClinical studiesClinical implicationsNeural circuitsCannabis useBrain functionOscillatory disruptionsNeural activityCannabinoidsSensationPotential relationshipCritical mechanismElectroencephalographyDisruptionSchizophreniaThe relationship between cannabis use and taurine: A MRS and metabolomics study
Newman S, Martin A, Raymond D, Cheng H, Wilson L, Barnes S, O’Donnell B. The relationship between cannabis use and taurine: A MRS and metabolomics study. PLOS ONE 2022, 17: e0269280. PMID: 35653401, PMCID: PMC9162360, DOI: 10.1371/journal.pone.0269280.Peer-Reviewed Original ResearchConceptsTaurine levelsCB useBody compositionLow-BMI individualsDorsal anterior cingulateMagnetic resonance spectroscopyNon-user groupNeuroprotective effectsBMI individualsNeurotoxic effectsMRS studiesUrine analysisAnterior cingulateCannabis useSimilar findingsUrine samplesTaurineEssential amino acidsMetabolomic analysisMetabolomics studiesGlutamateCurrent studyGroupBMILevelsDelta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior
Ganesh S, Cortes-Briones J, Martin A, Skosnik PD, D'Souza DC, Ranganathan M. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior. Cannabis And Cannabinoid Research 2022, 8: 846-856. PMID: 35319274, PMCID: PMC10589482, DOI: 10.1089/can.2021.0166.Peer-Reviewed Original ResearchConceptsPsychotomimetic effectsHuman laboratory studiesDifferent dose ratiosDose-related interactionDelta-9-TetrahydrocannabinolLower CBDNeural noiseRatio-dependent mannerCannabis liberalizationHealthy volunteersElectrophysiological biomarkersMedical indicationsPsychotomimetic statesSpecific brainDose ratioPrior exposureObjective effectsHuman brainMaximal attenuationBrainTHCAntagonistic effectCannabis plantNeuroscience investigationsBehavioral responses
2021
Metacognition, Adaptation, and Mental Health
Schnakenberg Martin A, Lysaker P. Metacognition, Adaptation, and Mental Health. Biological Psychiatry 2021, 91: e31-e32. PMID: 34961623, DOI: 10.1016/j.biopsych.2021.09.028.Peer-Reviewed Original ResearchTreatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review
Meshberg-Cohen S, MacLean R, Martin A, Sofuoglu M, Petrakis IL. Treatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review. Addictive Behaviors 2021, 122: 107026. PMID: 34182307, DOI: 10.1016/j.addbeh.2021.107026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderComorbid opioid use disorderStress disorderImpact of PTSDPresence of PTSDComorbid posttraumatic stress disorderUse disordersOpioid use disorderMultiple mental health problemsMental health problemsPTSD treatmentComparison participantsTreatment outcomesPTSD diagnosisPsychosocial problemsStandardized assessmentConcurrent diagnosisPsychiatric conditionsMedical record diagnosisDrug useIndividualsDisordersPublic health emergencyRecord diagnosisInclusion criteriaAltered cerebellar-cortical resting-state functional connectivity in cannabis users
Martin A, Kim DJ, Newman SD, Cheng H, Hetrick WP, Mackie K, O’Donnell B. Altered cerebellar-cortical resting-state functional connectivity in cannabis users. Journal Of Psychopharmacology 2021, 35: 823-832. PMID: 34034553, PMCID: PMC8813046, DOI: 10.1177/02698811211019291.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNon-using peersCannabis usersCannabis useFunctional connectivityRegular cannabis usersPosterior cingulate cortexAnterior cerebellar regionsNon-motor phenomenaCingulate cortexCerebellar regionsBrain regionsAge of initiationCerebral regionsCerebellar lobulesCortexPeersLifetime useUnbiased atlas templateIndividual voxelsCerebral cortexReceptor densityCognitionCerebellumAtlas template
2020
Meaning, integration, and the self in serious mental illness: Implications of research in metacognition for psychiatric rehabilitation.
Lysaker PH, Kukla M, Leonhardt BL, Hamm JA, Schnakenberg Martin A, Zalzala AB, Gagen EC, Hasson-Ohayon I. Meaning, integration, and the self in serious mental illness: Implications of research in metacognition for psychiatric rehabilitation. Psychiatric Rehabilitation Journal 2020, 43: 275-283. PMID: 32790437, DOI: 10.1037/prj0000436.Peer-Reviewed Original ResearchIn an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers
Schindler EAD, Schnakenberg Martin AM, Sewell RA, Ranganathan M, DeForest A, Pittman BP, Perrino A, D’Souza D. In an exploratory randomized, double-blind, placebo-controlled, cross-over study, psychoactive doses of intravenous delta-9-tetrahydrocannabinol fail to produce antinociceptive effects in healthy human volunteers. Psychopharmacology 2020, 237: 3097-3107. PMID: 32632491, DOI: 10.1007/s00213-020-05595-9.Peer-Reviewed Original ResearchConceptsCapsaicin-induced hyperalgesiaCross-over studyHealthy human subjectsIntravenous THCAcute painAntinociceptive effectDrug effectsDrug AdministrationHuman subjectsDose-related mannerPeak drug effectHealthy human volunteersSignificant antinociceptive propertiesRationaleAnimal studiesElectrical painPain conditionsPain managementChemical painPain ratingsAntinociceptive propertiesHealthy volunteersPsychoactive dosesAcute chemicalHuman studiesCognitive alterations
2019
An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users
Newman SD, Cheng H, Kim DJ, Schnakenberg-Martin A, Dydak U, Dharmadhikari S, Hetrick W, O’Donnell B. An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. Brain Imaging And Behavior 2019, 14: 2062-2071. PMID: 31302844, PMCID: PMC6955389, DOI: 10.1007/s11682-019-00165-w.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlu levelsState connectivityMultimodal MRI studyState functional connectivityRight nucleus accumbensCB useChronic cannabis usersNAc connectivityHealthy controlsGlutamatergic signalingMRI studiesAnimal studiesCurrent preliminary studyLarger sample sizeMagnetic resonance spectroscopyFunctional connectivityHeavy cannabisCannabis usersCannabisReward networkCB usersLinear regression modelsRSFCEffect sizeIndividuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers
Martin A, Lysaker PH. Individuals with psychosis and a lifetime history of cannabis use show greater deficits in emotional experience compared to non-using peers. Journal Of Mental Health 2019, 29: 77-83. PMID: 30822177, DOI: 10.1080/09638237.2018.1487540.Peer-Reviewed Original ResearchConceptsEmotional Expressivity ScaleEmotional experienceSocial Functioning ScaleEmotional expressionAnticipatory pleasureLifetime cannabisSocial functioningGreater deficitsSocial functionCannabis useNon-using peersAnticipation of pleasureExperience of pleasurePoor social functionEmotional expressivityLifetime historyAnticipatory anhedoniaProsocial activitiesActive cannabisPleasure ScaleTemporal experienceHistory of cannabisFunctioning ScaleEarly psychosisPrevious research
2018
Aberrant structural–functional coupling in adult cannabis users
Kim D, Martin A, Shin Y, Jo HJ, Cheng H, Newman SD, Sporns O, Hetrick WP, Calkins E, O'Donnell BF. Aberrant structural–functional coupling in adult cannabis users. Human Brain Mapping 2018, 40: 252-261. PMID: 30203892, PMCID: PMC6289814, DOI: 10.1002/hbm.24369.Peer-Reviewed Original ResearchConceptsStructural-functional couplingSC-FC couplingResting-state functional imagingCB usersPrimary outcome measureCannabis usersCB1 receptor densityRegion-specific disruptionCB useChronic cannabis useFunctional brain connectivityRich-club organizationOutcome measuresReceptor densitySynaptic plasticityRich-club analysisCannabis useFunctional connectivityBrain connectivityFunctional imagingAdult cannabis usersFunctional couplingBrain networksPositive associationHippocampusThe effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial
Boggs DL, Surti T, Gupta A, Gupta S, Niciu M, Pittman B, Schnakenberg Martin AM, Thurnauer H, Davies A, D’Souza D, Ranganathan M. The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial. Psychopharmacology 2018, 235: 1923-1932. PMID: 29619533, DOI: 10.1007/s00213-018-4885-9.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAffectAntipsychotic AgentsCannabidiolChronic DiseaseCognitionCognitive DysfunctionDouble-Blind MethodFemaleFollow-Up StudiesHumansMaleMental Status and Dementia TestsMiddle AgedOutpatientsPsychiatric Status Rating ScalesSchizophreniaSchizophrenic PsychologyTreatment OutcomeConceptsMATRICS Consensus Cognitive BatterySide effectsChronic schizophreniaAntipsychotic-treated patientsMovement side effectsFixed-dose studyPlacebo-treated subjectsWeeks of treatmentPANSS total scoreEffects of cannabidiolWorsening of moodNegative Syndrome ScaleAntipsychotic-treated outpatients× time effect× time interactionMCCB composite scoreOral cannabidiolCBD groupClinical trialsParallel groupPANSS scoresMethodsThis studyPsychotic symptomsConsensus Cognitive BatterySyndrome Scale
2017
Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information
Ranganathan M, Radhakrishnan R, Addy PH, Schnakenberg-Martin AM, Williams AH, Carbuto M, Elander J, Pittman B, Sewell R, Skosnik PD, D'Souza DC. Tetrahydrocannabinol (THC) impairs encoding but not retrieval of verbal information. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2017, 79: 176-183. PMID: 28642081, DOI: 10.1016/j.pnpbp.2017.06.019.Peer-Reviewed Original ResearchConceptsRey Auditory Verbal Learning TestVerbal informationInfluence of tetrahydrocannabinolVerbal Learning TestMemory-impairing effectsTotal immediate recallNon-verbal informationImpairs memory consolidationAdministration of tetrahydrocannabinolAcute memory impairmentPrincipal psychoactive constituentVerbal memoryImmediate recallIntravenous tetrahydrocannabinolLearning TestMemory consolidationComponent processesNeural synchronyMemory impairmentInformation processingUse of cannabisCannabis intoxicationRecallPsychoactive constituentEncodingThe positive link between executive function and lifetime cannabis use in schizophrenia is not explained by current levels of superior social cognition
Helle S, Løberg EM, Gjestad R, Martin A, Lysaker PH. The positive link between executive function and lifetime cannabis use in schizophrenia is not explained by current levels of superior social cognition. Psychiatry Research 2017, 250: 92-98. PMID: 28152399, DOI: 10.1016/j.psychres.2017.01.047.Peer-Reviewed Original ResearchConceptsSocial cognitionTheory of mindExecutive functionCannabis useBell-Lysaker Emotion Recognition TestEmotion Recognition TestExecutive Functioning ScaleBetter executive functionRegular cannabis useStructural equation modelingHinting testIllicit substancesNeurocognitive vulnerabilityRecognition testNeurocognitive performanceNeurocognitive deficitsCognitionEquation modelingFlexibility componentsAlcohol useFunctioning ScaleLifetime cannabisIndirect effectsPositive linkSchizophrenia
2015
GABA Deficits Enhance the Psychotomimetic Effects of Δ9-THC
Radhakrishnan R, Skosnik PD, Cortes-Briones J, Sewell RA, Carbuto M, Schnakenberg A, Cahill J, Bois F, Gunduz-Bruce H, Pittman B, Ranganathan M, D'Souza DC. GABA Deficits Enhance the Psychotomimetic Effects of Δ9-THC. Neuropsychopharmacology 2015, 40: 2047-2056. PMID: 25728472, PMCID: PMC4839528, DOI: 10.1038/npp.2015.58.Peer-Reviewed Original Research
2014
Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism
Ranganathan M, Sewell RA, Carbuto M, Elander J, Schnakenberg A, Radhakrishnan R, Pittman B, D’Souza D. Effects of Δ9-tetrahydrocannabinol in individuals with a familial vulnerability to alcoholism. Psychopharmacology 2014, 231: 2385-2393. PMID: 24424782, DOI: 10.1007/s00213-013-3402-4.Peer-Reviewed Original ResearchConceptsPerceptual alterationsRewarding effectsSubjective effectsAlcohol-related behaviorsΔ9-THCExecutive functionEffects of alcoholSpatial memoryMemory impairmentCounterbalanced orderAlcohol problemsFamilial vulnerabilityCannabinoid receptor functionΔ9-tetrahydrocannabinolCannabinoid Δ9-tetrahydrocannabinolFirst human studyDouble-blind conditionsCB1R functionOutcome measuresIndividualsMemoryMeasuresAlcoholismSecondary outcome measuresHuman studies
2012
Acute effects of THC on time perception in frequent and infrequent cannabis users
Sewell RA, Schnakenberg A, Elander J, Radhakrishnan R, Williams A, Skosnik PD, Pittman B, Ranganathan M, D’Souza D. Acute effects of THC on time perception in frequent and infrequent cannabis users. Psychopharmacology 2012, 226: 401-413. PMID: 23179965, PMCID: PMC3581701, DOI: 10.1007/s00213-012-2915-6.Peer-Reviewed Original ResearchConceptsCannabis smokersAcute effectsFrequent cannabis smokersPlacebo-controlled studyCannabis usersChronic cannabis smokersInfrequent cannabis usersWhole-plant cannabisChronic cannabis useResultsAll dosesVariable pharmacokineticsBlunted responseSubjects three timesHigh dosesTHC effectsFrequent cannabis usersCannabis useInternal clock speedΔ9-tetrahydrocannabinolSmall sample sizeDosesFrequent cannabisThree timesTest daySmokers