2022
Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan
Baranov V, Frost A, Hagaman A, Simmons J, Manzoor M, Biroli P, Bhalotra S, Rahman A, Sikander S, Maselko J. Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan. SSM - Mental Health 2022, 2: 100082. PMID: 37441003, PMCID: PMC10338030, DOI: 10.1016/j.ssmmh.2022.100082.Peer-Reviewed Original ResearchHPA axis activityPerinatal depression interventionAxis activityEUC groupDHEAS levelsDepression interventionsIntervention groupCommunity-based randomized control trialIntervention effectsHPA axis functionMaternal cortisol levelsHigher DHEAS levelsUseful clinical indicatorRandomized control trialLong-term HPA axis activityPhysiological stress systemsUsual careHPA hormonesAxis functionYear postpartumAdrenal axisCognitive-behavioral interventionsClinical indicatorsInfant healthInfant cortisol
2020
Effectiveness of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal: a cluster randomised trial in Pakistan
Maselko J, Sikander S, Turner EL, Bates LM, Ahmad I, Atif N, Baranov V, Bhalotra S, Bibi A, Bibi T, Bilal S, Biroli P, Chung E, Gallis JA, Hagaman A, Jamil A, LeMasters K, O'Donnell K, Scherer E, Sharif M, Waqas A, Zaidi A, Zulfiqar S, Rahman A. Effectiveness of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal: a cluster randomised trial in Pakistan. The Lancet Psychiatry 2020, 7: 775-787. PMID: 32828167, PMCID: PMC8015797, DOI: 10.1016/s2215-0366(20)30258-3.Peer-Reviewed Original ResearchConceptsMaternal depressionPsychosocial interventionsUsual careLong-term maternal outcomesMaternal depression symptomsAllocation statusScalable psychosocial interventionsMaternal outcomesRandomisation sequencePrimary outcomePregnant womenExcess riskDepression exposureRecurring courseSevere symptomsTrial participantsOffspring outcomesDepression symptomsDepressionVillage clustersInterventionTrialsOutcomesSymptomsPrincipal investigator