Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan
Hagaman AK, Baranov V, Chung E, LeMasters K, Andrabi N, Bates LM, Rahman A, Sikander S, Turner E, Maselko J. Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan. Journal Of Affective Disorders 2020, 276: 592-599. PMID: 32871690, PMCID: PMC7792907, DOI: 10.1016/j.jad.2020.07.053.Peer-Reviewed Original ResearchConceptsHPA axis activityMaternal depressionSocio-economic statusYear postpartumDHEAS levelsAxis activityIntimate partner violenceInfant stress response systemsSignificant associationLow DHEAS levelsHPA axis dysregulationHPA axis hormonesOne-year-old infantsYears of ageConsistent significant associationsChildren's HPA-axis activityHigher socio-economic statusSignificant positive associationAxis dysregulationAxis hormonesAdrenal axisStress-related diseasesDHEA activityInfant cortisolDepression severity