2022
Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan
Baranov V, Frost A, Hagaman A, Simmons J, Manzoor M, Biroli P, Bhalotra S, Rahman A, Sikander S, Maselko J. Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan. SSM - Mental Health 2022, 2: 100082. PMID: 37441003, PMCID: PMC10338030, DOI: 10.1016/j.ssmmh.2022.100082.Peer-Reviewed Original ResearchHPA axis activityPerinatal depression interventionAxis activityEUC groupDHEAS levelsDepression interventionsIntervention groupCommunity-based randomized control trialIntervention effectsHPA axis functionMaternal cortisol levelsHigher DHEAS levelsUseful clinical indicatorRandomized control trialLong-term HPA axis activityPhysiological stress systemsUsual careHPA hormonesAxis functionYear postpartumAdrenal axisCognitive-behavioral interventionsClinical indicatorsInfant healthInfant cortisol
2020
Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan
Hagaman AK, Baranov V, Chung E, LeMasters K, Andrabi N, Bates LM, Rahman A, Sikander S, Turner E, Maselko J. Association of maternal depression and home adversities with infant hypothalamic-pituitary-adrenal (HPA) axis biomarkers in rural Pakistan. Journal Of Affective Disorders 2020, 276: 592-599. PMID: 32871690, PMCID: PMC7792907, DOI: 10.1016/j.jad.2020.07.053.Peer-Reviewed Original ResearchConceptsHPA axis activityMaternal depressionSocio-economic statusYear postpartumDHEAS levelsAxis activityIntimate partner violenceInfant stress response systemsSignificant associationLow DHEAS levelsHPA axis dysregulationHPA axis hormonesOne-year-old infantsYears of ageConsistent significant associationsChildren's HPA-axis activityHigher socio-economic statusSignificant positive associationAxis dysregulationAxis hormonesAdrenal axisStress-related diseasesDHEA activityInfant cortisolDepression severity