Embryo implantation evolved from an ancestral inflammatory attachment reaction
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6566-e6575. PMID: 28747528, PMCID: PMC5559003, DOI: 10.1073/pnas.1701129114.Peer-Reviewed Original ResearchConceptsTerm pregnancyMaterno-fetal interfaceEGF-like growth factorInflammatory responseImmune responseEmbryo implantationPregnancyGrowth factorMucin 1Molecular changesImplantationKey markersMiceParturitionExhibit expressionMorphological changesHumansOpossumEutherian mammalsUterusImmunohistochemistryTranscriptomic analysisPlacentaImplantation reactionLocalization profilesEvolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening
Wagner GP, Nnamani MC, Chavan AR, Maziarz J, Protopapas S, Condon J, Romero R. Evolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening. Scientific Reports 2017, 7: 4439. PMID: 28667298, PMCID: PMC5493687, DOI: 10.1038/s41598-017-04759-6.Peer-Reviewed Original ResearchConceptsGene expressionComparative transcriptomic studyEutherian mammalsPlacental mammalsCervical ripeningTranscriptomic studiesEutherian speciesSteroid signalingUterine cervixChange expressionTiming of parturitionMammalsPremature cervical ripeningFunctional progesterone withdrawalDecreased expressionMaintenance of pregnancyExpressionSpeciesRipeningPutative mechanismsPreterm birthProgesterone withdrawalProgesterone receptorMouse cervixCervix