2020
Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals
Chavan AR, Griffith OW, Stadtmauer D, Maziarz J, Pavlicev M, Fishman R, Koren L, Romero R, Wagner GP. Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals. Molecular Biology And Evolution 2020, 38: 1060-1074. PMID: 33185661, PMCID: PMC7947829, DOI: 10.1093/molbev/msaa274.Peer-Reviewed Original ResearchConceptsEutherian mammalsEutherian lineagesDecidual stromal cellsNovel cell typesStromal cellsInflammatory responseStem lineageEutherian pregnancyCommon ancestorEvolutionary mechanismsExtended gestationMost marsupialsEmbryo attachmentEmbryo implantationMarsupialsLineagesCell typesMammalsMechanistic understandingEutheriansHelper T cellsFetal-maternal interfaceMammalian pregnancyMaternal tissuesNeutrophil recruitment
2018
The mammalian decidual cell evolved from a cellular stress response
Erkenbrack EM, Maziarz JD, Griffith OW, Liang C, Chavan AR, Nnamani MC, Wagner GP. The mammalian decidual cell evolved from a cellular stress response. PLOS Biology 2018, 16: e2005594. PMID: 30142145, PMCID: PMC6108454, DOI: 10.1371/journal.pbio.2005594.Peer-Reviewed Original ResearchConceptsCellular stress responseNovel cell typesStress responseEndometrial stromal fibroblastsCell typesCell type diversityDecidual stromal cellsCore regulatory genesOxidative stress responseDecidual cell typesEvolutionary noveltyPrecursor cell typesEffector genesRegulatory genesEutherian mammalsTranscription factorsOpossum Monodelphis domesticaOrganismal structureType diversityMolecular mechanismsAnimal speciesMonodelphis domesticaGenesStromal cellsSpecies
2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, Wagner GP. The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology And Evolution 2016, 8: 2459-2473. PMID: 27401177, PMCID: PMC5010902, DOI: 10.1093/gbe/evw168.Peer-Reviewed Original ResearchConceptsEndometrial stromal fibroblastsGene expression changesTherian speciesEutherian lineagesTranscriptome compositionBovine lineageStem lineageNatural selectionStromal fibroblastsTherian mammalsEutherian mammalsKey genesLoss of expressionTranscriptomic evolutionGene expressionExpression changesLatter cell typeGenesLineagesCell typesCell type presentMammalsMammalian pregnancyExpressionTissue invasion