Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity
Fraser H, Levy S, Chavan A, Shah H, Perez J, Zhou Y, Siegal M, Sinha H. Polygenic cis-regulatory adaptation in the evolution of yeast pathogenicity. Genome Research 2012, 22: 1930-1939. PMID: 22645260, PMCID: PMC3460188, DOI: 10.1101/gr.134080.111.Peer-Reviewed Original ResearchConceptsSingle-allele knockoutEvolution of pathogenicityDiverse yeast strainsCis-regulatory mutationsMode of evolutionWild-type progenitorPathogenic yeastsGene expression levelsPolygenic adaptationSelective sweepsPathogenic lifestyleNew genesMorphological traitsYeast SaccharomycesMammalian hostsMicrobial pathogenicityHorizontal transferStandard laboratory conditionsGene expressionCompensatory mutationsYeast pathogenicityYeast strainGrowth advantagePleiotropic effectsGenetic variants