2018
Genetic Associations With Gestational Duration and Spontaneous Preterm Birth
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia L, Juodakis J, Miller D, Litterman N, Jiang P, Russell L, Hinds D, Hu Y, Weirauch M, Chen X, Chavan A, Wagner G, Pavliev M, Nnamani M, Maziarz J, Karjalainen M, Ramet M, Sengpiel V, Geller F, Boyd H, Palotie A, Momany A, Bedell B, Ryckman K, Huusko J, Forney C, Kottyan L, Hallman M, Teramo K, Nohr E, Smith G, Melbye M, Jacobsson B, Muglia L. Genetic Associations With Gestational Duration and Spontaneous Preterm Birth. Obstetrical & Gynecological Survey 2018, 73: 83-85. DOI: 10.1097/01.ogx.0000530434.15441.45.Peer-Reviewed Original Research
2017
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia LM, Juodakis J, Miller DE, Litterman N, Jiang PP, Russell L, Hinds DA, Hu Y, Weirauch MT, Chen X, Chavan AR, Wagner GP, Pavličev M, Nnamani MC, Maziarz J, Karjalainen MK, Rämet M, Sengpiel V, Geller D, Boyd HA, Palotie A, Momany A, Bedell B, Ryckman KK, Huusko JM, Forney CR, Kottyan LC, Hallman M, Teramo K, Nohr EA, Davey-Smith G, Melbye M, Jacobsson B, Muglia LJ. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal Of Medicine 2017, 377: 1156-1167. PMID: 28877031, PMCID: PMC5561422, DOI: 10.1056/nejmoa1612665.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesDatasets as TopicFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGestational AgeHumansPeptide Elongation FactorsPhenotypePolymorphism, Single NucleotidePregnancyPremature BirthRas ProteinsReceptor, Angiotensin, Type 2Regression AnalysisTrans-ActivatorsWnt4 ProteinConceptsGestational durationPreterm birthDiscovery setSpontaneous preterm birthDuration of gestationMother-infant dyadsGenomewide association studiesGenetic associationVascular controlMaternal nutritionSignificant genomewide associationEstrogen receptorPossible genetic associationDichotomous outcomesUterine developmentGenetic factorsMechanistic involvementReplication data setsAssociation studiesBirthSuggestive significanceGenomewide significanceAGTR2Replication setAssociationEvolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening
Wagner GP, Nnamani MC, Chavan AR, Maziarz J, Protopapas S, Condon J, Romero R. Evolution of Gene Expression in the Uterine Cervix related to Steroid Signaling: Conserved features in the regulation of cervical ripening. Scientific Reports 2017, 7: 4439. PMID: 28667298, PMCID: PMC5493687, DOI: 10.1038/s41598-017-04759-6.Peer-Reviewed Original ResearchConceptsGene expressionComparative transcriptomic studyEutherian mammalsPlacental mammalsCervical ripeningTranscriptomic studiesEutherian speciesSteroid signalingUterine cervixChange expressionTiming of parturitionMammalsPremature cervical ripeningFunctional progesterone withdrawalDecreased expressionMaintenance of pregnancyExpressionSpeciesRipeningPutative mechanismsPreterm birthProgesterone withdrawalProgesterone receptorMouse cervixCervix