Embryo implantation evolved from an ancestral inflammatory attachment reaction
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6566-e6575. PMID: 28747528, PMCID: PMC5559003, DOI: 10.1073/pnas.1701129114.Peer-Reviewed Original ResearchConceptsTerm pregnancyMaterno-fetal interfaceEGF-like growth factorInflammatory responseImmune responseEmbryo implantationPregnancyGrowth factorMucin 1Molecular changesImplantationKey markersMiceParturitionExhibit expressionMorphological changesHumansOpossumEutherian mammalsUterusImmunohistochemistryTranscriptomic analysisPlacentaImplantation reactionLocalization profilesSingle-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface
Pavličev M, Wagner GP, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research 2017, 27: 349-361. PMID: 28174237, PMCID: PMC5340963, DOI: 10.1101/gr.207597.116.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsG protein-coupled receptorsCell communication networksGene expression profilesReceptor-ligand pairsCell type identificationOrganismal functionInteraction hubTrophoblast cellsGene expressionExpression profilesEndometrial stromal fibroblastsSpecific expressionCell typesInteractomeTranscriptomicsRich resourceCell interactionsPlacental trophoblast cellsDecidual cellsImmune signalsStromal cellsGrowth factorStromal fibroblastsEndometrial stromal cells