2014
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders
Coplan JD, Fulton SL, Reiner W, Jackowski A, Panthangi V, Perera TD, Gorman JM, Huang YY, Tang CY, Hof PR, Kaffman A, Dwork AJ, Mathew SJ, Kaufman J, Mann JJ. Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders. Frontiers In Behavioral Neuroscience 2014, 8: 440. PMID: 25566007, PMCID: PMC4274982, DOI: 10.3389/fnbeh.2014.00440.Peer-Reviewed Original ResearchEarly life stressRight hippocampal volumeHippocampal volumeCerebrospinal fluidFractional anisotropySerotonin neurotransmissionMonoamine metabolitesNeurotrophic activitySmaller right hippocampal volumeAnxiety disordersHigh cerebrospinal fluidElevated cerebrospinal fluidWhite matter fractional anisotropyEffects of ELSLife stressMonths of ageReduced fractional anisotropyWM fractional anisotropySerotonin deficitVFD subjectsDorsal rapheMacaque modelCSF tapsInternal capsuleNeurotrophic effectsEarly life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene
Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J. Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene. Frontiers In Behavioral Neuroscience 2014, 8: 342. PMID: 25339875, PMCID: PMC4186477, DOI: 10.3389/fnbeh.2014.00342.Peer-Reviewed Original ResearchLarger amygdala volumesAmygdala volumeSerotonin transporter geneFractional anisotropyCerebrospinal fluid concentrationsEarly life stressRight amygdala volumeAnxiety-like responsesHippocampal neurogenesisInternal capsuleAnterior limbMRI scansLeft amygdalaSecondary analysisFluid concentrationsYoung adulthoodTransporter geneLife stressNeurobiological parametersPersistent changesHypertrophyPreliminary evidenceShort alleleAdulthoodStress-related variables
2010
The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates
Coplan JD, Abdallah CG, Tang CY, Mathew SJ, Martinez J, Hof PR, Smith EL, Dwork AJ, Perera TD, Pantol G, Carpenter D, Rosenblum LA, Shungu DC, Gelernter J, Kaffman A, Jackowski A, Kaufman J, Gorman JM. The role of early life stress in development of the anterior limb of the internal capsule in nonhuman primates. Neuroscience Letters 2010, 480: 93-96. PMID: 20541590, PMCID: PMC2951885, DOI: 10.1016/j.neulet.2010.06.012.Peer-Reviewed Original ResearchConceptsDeep brain stimulationInternal capsuleDiffusion tensor imagingWhite matterFractional anisotropyAnterior limbNonhuman primate modelWhite matter impairmentAdult male bonnet macaquesOccipital white matterEarly life stressWhite matter tract integrityWhite matter integrityParental verbal abuseMother-infant attachmentPrimate modelPosterior limbBrain stimulationTract integrityTensor imagingAnxiety disordersAnxiety scoresMale bonnet macaquesLife stressSignificant reduction