Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus
Wei L, Hao J, Kaffman A. Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus. PLOS ONE 2014, 9: e115283. PMID: 25517398, PMCID: PMC4269428, DOI: 10.1371/journal.pone.0115283.Peer-Reviewed Original ResearchConceptsEarly life stressSecond weekHippocampal growthAbnormal hippocampal functionNormal hippocampal developmentNormal mouse hippocampusLife stressMaternal separationMouse hippocampusMouse modelHippocampal developmentHippocampal functionHippocampus developmentNovel molecular mechanismDaily separationHippocampusWeeksDNA methylationInhibits expressionAdulthoodExposureMolecular mechanismsRNA contentGradual declineNormal growthEarly life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene
Coplan JD, Fathy HM, Jackowski AP, Tang CY, Perera TD, Mathew SJ, Martinez J, Abdallah CG, Dwork AJ, Pantol G, Carpenter D, Gorman JM, Nemeroff CB, Owens MJ, Kaffman A, Kaufman J. Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene. Frontiers In Behavioral Neuroscience 2014, 8: 342. PMID: 25339875, PMCID: PMC4186477, DOI: 10.3389/fnbeh.2014.00342.Peer-Reviewed Original ResearchLarger amygdala volumesAmygdala volumeSerotonin transporter geneFractional anisotropyCerebrospinal fluid concentrationsEarly life stressRight amygdala volumeAnxiety-like responsesHippocampal neurogenesisInternal capsuleAnterior limbMRI scansLeft amygdalaSecondary analysisFluid concentrationsYoung adulthoodTransporter geneLife stressNeurobiological parametersPersistent changesHypertrophyPreliminary evidenceShort alleleAdulthoodStress-related variables