Anupama Hemalatha
Associate Research Scientist in GeneticsCards
About
Research
Publications
2024
Selective utilization of glucose metabolism guides mammalian gastrulation
Cao D, Bergmann J, Zhong L, Hemalatha A, Dingare C, Jensen T, Cox A, Greco V, Steventon B, Sozen B. Selective utilization of glucose metabolism guides mammalian gastrulation. Nature 2024, 634: 919-928. PMID: 39415005, PMCID: PMC11499262, DOI: 10.1038/s41586-024-08044-1.Peer-Reviewed Original ResearchConceptsCellular metabolismMammalian gastrulationHexosamine biosynthetic pathwayTranscription factor networksCellular signaling pathwaysSignaling morphogensGlucose metabolismCellular programmeBiosynthetic pathwayFate acquisitionCell fateHousekeeping natureGenetic mechanismsMesoderm migrationFactor networksERK activationExpression patternsSignaling pathwayDevelopmental processesStem cell modelCell typesSpecialized functionsDevelopmental contextMammalian embryosMouse embryos
2021
Metabolic decisions in development and disease—a Keystone Symposia report
Cable J, Pourquié O, Wellen K, Finley L, Aulehla A, Gould A, Teleman A, Tu W, Garrett W, Miguel‐Aliaga I, Perrimon N, Hooper L, Walhout A, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz J, Hemalatha A, Gutiérrez‐Pérez P, Chandel N, Rutter J, Locasale J, Landoni J, Christofk H. Metabolic decisions in development and disease—a Keystone Symposia report. Annals Of The New York Academy Of Sciences 2021, 1506: 55-73. PMID: 34414571, DOI: 10.1111/nyas.14678.Peer-Reviewed Original ResearchConceptsMetabolic decisionsProtein post-translational modificationsCell decision makingPost-translational modificationsKeystone Symposia reportCell-type specificPrecise metabolic controlDevelopmental decisionsCell fateDevelopmental biologyKeystone eSymposiumCell signalingAllosteric mechanismCell statesProtein activityGene expressionEpigenetic markersMetabolic enzymesCell metabolismRole of metabolismHuman diseasesMetabolic pathwaysNormal developmentEnzyme activityModel system
2019
Recent advances in clathrin-independent endocytosis
Hemalatha A, Mayor S. Recent advances in clathrin-independent endocytosis. F1000Research 2019, 8: f1000 faculty rev-138. PMID: 30774931, PMCID: PMC6357988, DOI: 10.12688/f1000research.16549.1.Peer-Reviewed Original Research
2016
Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling in Drosophila wing discs
Hemalatha A, Prabhakara C, Mayor S. Endocytosis of Wingless via a dynamin-independent pathway is necessary for signaling in Drosophila wing discs. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e6993-e7002. PMID: 27791132, PMCID: PMC5111669, DOI: 10.1073/pnas.1610565113.Peer-Reviewed Original ResearchWing discEndocytic pathwayCLIC/GEEC pathwayDistinct endocytic pathwaysDynamin-dependent endocytic pathwayDynamin-independent pathwayDynamin-dependent endocytosisDorso-ventral patternDrosophila wing discClass I PI3K.Multiple endocytic pathwaysLigand-receptor complexesSignal transductionDFz2EndocytosisApical surfaceWinglessEndosomesPathwayDfrizzled2WGARF1ClathrinGarzTransduction