2016
Second‐opinion interpretations of neuroimaging studies by oncologic neuroradiologists can help reduce errors in cancer care
Hatzoglou V, Omuro AM, Haque S, Khakoo Y, Ganly I, Oh JH, Shukla-Dave A, Fatovic R, Gaal J, Holodny AI. Second‐opinion interpretations of neuroimaging studies by oncologic neuroradiologists can help reduce errors in cancer care. Cancer 2016, 122: 2708-2714. PMID: 27219108, PMCID: PMC4992439, DOI: 10.1002/cncr.30083.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolDiagnostic ErrorsFemaleFollow-Up StudiesHumansImage Interpretation, Computer-AssistedInfantMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingNeoplasmsNeuroimagingObserver VariationPatient CarePhysiciansPrognosisRadiologistsReferral and ConsultationRetrospective StudiesTomography, X-Ray ComputedYoung AdultConceptsSecond-opinion interpretationsPatient managementMagnetic resonance imaging studySecond-opinion radiology reportsResonance imaging studyNational Cancer InstitutePatient ageNeuro-oncologistsCancer CenterDisease stageStudy criteriaCancer patientsClinical assessmentClinical impactNeck surgeonsRetrospective analysisHistopathologic analysisCancer InstituteImaging studiesRadiology reportsOutside reportsReference standardNeuroradiologistsSurgeonsDiscrepant reports
2013
Primary leptomeningeal lymphoma
Taylor JW, Flanagan EP, O'Neill BP, Siegal T, Omuro A, DeAngelis L, Baehring J, Nishikawa R, Pinto F, Chamberlain M, Hoang-Xuan K, Gonzalez-Aguilar A, Batchelor T, Blay JY, Korfel A, Betensky RA, Lopes MB, Schiff D. Primary leptomeningeal lymphoma. Neurology 2013, 81: 1690-1696. PMID: 24107866, PMCID: PMC3812109, DOI: 10.1212/01.wnl.0000435302.02895.f3.Peer-Reviewed Original ResearchConceptsPrimary leptomeningeal lymphomaPrimary CNS lymphomaLeptomeningeal lymphomaCNS lymphomaLeptomeningeal enhancementCSF cytologyMedian Eastern Cooperative Oncology Group performance statusRare formEastern Cooperative Oncology Group performance statusInternational Primary CNS Lymphoma Collaborative GroupIntra-CSF chemotherapyMedian overall survivalFavorable clinical responseCases of lymphomaOptimal diagnostic evaluationGene rearrangement studiesB-cell lymphomaMultifocal symptomsSalvage treatmentSystemic chemotherapyClinical responseOverall survivalPerformance statusMedian ageSystemic involvementHistological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System
Raghunathan A, Wani K, Armstrong TS, Vera‐Bolanos E, Fouladi M, Gilbertson R, Gajjar A, Goldman S, Lehman NL, Metellus P, Mikkelsen T, Necesito‐Reyes M, Omuro A, Packer RJ, Partap S, Pollack IF, Prados MD, Robins HI, Soffietti R, Wu J, Miller CR, Gilbert MR, Aldape KD, Network C. Histological Predictors of Outcome in Ependymoma are Dependent on Anatomic Site Within the Central Nervous System. Brain Pathology 2013, 23: 584-594. PMID: 23452038, PMCID: PMC8028973, DOI: 10.1111/bpa.12050.Peer-Reviewed Original ResearchConceptsProgression-free survivalWorse progression-free survivalElevated mitotic rateAnatomic sitesPosterior fossaHistological featuresMicrovascular proliferationMitotic rateWorld Health Organization grade IIComposite histological scoresMultivariate Cox regressionWorse clinical outcomesSpecific histological featuresRelevant clinical variablesDetailed histological examinationClinical outcomesCox regressionSC tumorsClinical variablesHistological factorsPF tumorsGrade IIHistological scoresEpendymal canalHistological examination
2012
MRI perfusion in determining pseudoprogression in patients with glioblastoma
Young RJ, Gupta A, Shah AD, Graber JJ, Chan TA, Zhang Z, Shi W, Beal K, Omuro AM. MRI perfusion in determining pseudoprogression in patients with glioblastoma. Clinical Imaging 2012, 37: 41-49. PMID: 23151413, PMCID: PMC4755513, DOI: 10.1016/j.clinimag.2012.02.016.Peer-Reviewed Original ResearchA prognostic gene expression signature in infratentorial ependymoma
Wani K, Armstrong TS, Vera-Bolanos E, Raghunathan A, Ellison D, Gilbertson R, Vaillant B, Goldman S, Packer RJ, Fouladi M, Pollack I, Mikkelsen T, Prados M, Omuro A, Soffietti R, Ledoux A, Wilson C, Long L, Gilbert MR, Aldape K, For the Collaborative Ependymoma Research Network. A prognostic gene expression signature in infratentorial ependymoma. Acta Neuropathologica 2012, 123: 727-738. PMID: 22322993, PMCID: PMC4013829, DOI: 10.1007/s00401-012-0941-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAntigens, NeoplasmChildCluster AnalysisDatabases, GeneticDNA Topoisomerases, Type IIDNA-Binding ProteinsEpendymomaFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansInfratentorial NeoplasmsLongitudinal StudiesMaleOligonucleotide Array Sequence AnalysisPrognosisReproducibility of ResultsSex FactorsSurvival AnalysisYoung AdultConceptsRecurrence-free survivalInfratentorial ependymomaClinical outcomesReal-time reverse transcriptase-polymerase chain reaction assaysReverse transcriptase-polymerase chain reaction assaysGroup 1 tumorsPrognostic gene expression signaturesTranscriptase-polymerase chain reaction assaysGroup 2 tumorsGene expression subgroupsPolymerase chain reaction assaysClinical factorsGene expression signaturesIndependent predictorsPrognostic significanceInfratentorial compartmentHistological factorsClinical behaviorChain reaction assaysClinical aggressivenessPrognostic signatureExpression subgroupsEpendymomaMolecular alterationsMultivariate analysis
2011
Potential utility of conventional MRI signs in diagnosing pseudoprogression in glioblastoma
Young R, Gupta A, Shah A, Graber J, Zhang Z, Shi W, Holodny A, Omuro A. Potential utility of conventional MRI signs in diagnosing pseudoprogression in glioblastoma. Neurology 2011, 76: 1918-1924. PMID: 21624991, PMCID: PMC3115805, DOI: 10.1212/wnl.0b013e31821d74e7.Peer-Reviewed Original ResearchConceptsEarly progressionMRI signsNegative predictive valuePredictive valueFinal diagnosisHigh negative predictive valueUseful MRI markerFisher's exact testSubependymal spreadSecond resectionRetrospective studyMass lesionSurgical specimensMRI markersPotential utilityClinical physiciansExact testMRI scansPatientsSubependymal enhancementLesionsGlioblastomaPseudoprogressionSignsDiagnosisCMV encephalitis in BMT recipients
Sarva H, Graber J, Remanan R, Rosenblum M, Omuro A. CMV encephalitis in BMT recipients. Bone Marrow Transplantation 2011, 47: 318-320. PMID: 21460874, DOI: 10.1038/bmt.2011.80.Peer-Reviewed Original Research