2017
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE. Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity. ACS Chemical Neuroscience 2017, 8: 1554-1569. PMID: 28418645, PMCID: PMC5517348, DOI: 10.1021/acschemneuro.7b00076.Peer-Reviewed Original ResearchConceptsLong-term potentiationCalpain sensitivityEffects of cocaineRat nucleus accumbensAdult rat nucleus accumbensRho GDP/GTP exchange factorRegion-specific effectsChronic cocaineNucleus accumbensSynaptic functionBrain regionsKALRN geneSpine morphologyPrefrontal cortexKal7CocainePotentiationFunctional significanceCalpainPhosphorylation
2013
Arg kinase signaling in dendrite and synapse stabilization pathways: Memory, cocaine sensitivity, and stress
Kerrisk ME, Koleske AJ. Arg kinase signaling in dendrite and synapse stabilization pathways: Memory, cocaine sensitivity, and stress. The International Journal Of Biochemistry & Cell Biology 2013, 45: 2496-2500. PMID: 23916785, PMCID: PMC3797846, DOI: 10.1016/j.biocel.2013.07.018.Peer-Reviewed Original ResearchConceptsNeuronal actin cytoskeletonPhosphorylation of substratesNonreceptor tyrosine kinaseArg nonreceptor tyrosine kinaseActin cytoskeletonPostnatal mouse brainDendritic spinesArg kinaseMolecular mechanismsF-actinTyrosine kinaseSignaling pathwaysPostnatal day 21Synapse stabilityIntegrin α3β1KinaseNeurodegenerative diseasesNeuronal remodelingTherapeutic approachesCocaine sensitivityStabilization pathwayDay 21Arbor sizeMouse brainArg
2012
Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior
Warren MS, Bradley WD, Gourley SL, Lin YC, Simpson MA, Reichardt LF, Greer CA, Taylor JR, Koleske AJ. Integrin β1 Signals through Arg to Regulate Postnatal Dendritic Arborization, Synapse Density, and Behavior. Journal Of Neuroscience 2012, 32: 2824-2834. PMID: 22357865, PMCID: PMC3313657, DOI: 10.1523/jneurosci.3942-11.2012.Peer-Reviewed Original ResearchMeSH KeywordsAlpha-FetoproteinsAnalysis of VarianceAnimalsAnimals, NewbornAvoidance LearningBasic Helix-Loop-Helix Transcription FactorsCells, CulturedCocaineDendritesEnzyme-Linked Immunosorbent AssayExploratory BehaviorGreen Fluorescent ProteinsGTPase-Activating ProteinsHippocampusImmunoprecipitationIntegrin beta1MaleMiceMice, KnockoutMutationNerve Tissue ProteinsNeuronsOrgan Culture TechniquesPost-Synaptic DensityProtein BindingRecognition, PsychologyRepressor ProteinsSignal TransductionSrc Homology DomainsSynapsesConceptsIntegrin β1Vertebrate nervous systemExtracellular matrix receptorsGenetic experimentsIntracellular tailGenetic manipulationRhoA GTPaseArg kinaseMatrix receptorsProper hippocampal functionProper developmentSynapse maintenanceDose-sensitive mannerImpaired hippocampus-dependent learningHippocampal dendritic arborsHippocampal synapse lossDendritic arbor sizeHippocampus-dependent learningΒ1ArgSelective lossGTPaseP190RhoGAPPsychomotor sensitivityKinaseArg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity
Gourley SL, Olevska A, Warren MS, Taylor JR, Koleske AJ. Arg Kinase Regulates Prefrontal Dendritic Spine Refinement and Cocaine-Induced Plasticity. Journal Of Neuroscience 2012, 32: 2314-2323. PMID: 22396406, PMCID: PMC3386297, DOI: 10.1523/jneurosci.2730-11.2012.Peer-Reviewed Original ResearchConceptsSpine densityAdolescent wild-type mouseHippocampal CA1 pyramidal neuronsDendritic spine densityCA1 pyramidal neuronsPostnatal day 60Wild-type miceDendritic spine developmentCocaine-Induced PlasticityAddictive-like behaviorsPyramidal neuronsCocaine sensitizationDendritic spinesPsychomotor sensitizationProtective consequencesSpine headsNeuropsychiatric disordersOrbitofrontal cortexDay 60Local applicationArg inhibitionPsychomotor sensitivityIntracellular mechanismsPsychostimulant sensitivitySpine development
2009
Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
Gourley SL, Koleske AJ, Taylor JR. Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16859-16864. PMID: 19805386, PMCID: PMC2742404, DOI: 10.1073/pnas.0902286106.Peer-Reviewed Original ResearchConceptsDopamine D2 receptor levelsLocomotor depressant actionsD2 receptor levelsWild-type micePsychomotor stimulant actionDendritic simplificationAntagonist haloperidolStimulant actionCocaine exposureCortical axonsDendritic arborsReceptor levelsCocaine administrationSynaptic pruningDendrite stabilizationNeuropsychiatric disordersArg inhibitionMiceNormal sensitivityDendritic refinementCytoskeletal stabilizationCocaineAdolescenceReversal taskRhoA GTPase