2018
Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies
Kim SY, Nair DM, Romero M, Serna VA, Koleske AJ, Woodruff TK, Kurita T. Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death & Differentiation 2018, 26: 502-515. PMID: 29988075, PMCID: PMC6370889, DOI: 10.1038/s41418-018-0151-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisFemaleHumansMiceOvaryPrimary Ovarian InsufficiencyTumor Suppressor Protein p53ConceptsDistinct apoptotic pathwaysDNA damage responseDamage-induced apoptosisTemporary repressionPhosphorylation of ATMOocyte-specific deletionActivation/phosphorylationKinase inhibitorsCDDP-induced apoptosisDamage responseMultiple kinasesMolecular basisP53 homologApoptotic pathwayNovel pathwayAbl kinase inhibitorsOvarian functionApoptosisPathwayRepressionTAp63αPhosphorylationOocytesATRImmature oocytes
2012
Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver
Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barilà D, Maina F. Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver. Journal Of Hepatology 2012, 57: 1292-1298. PMID: 22889954, PMCID: PMC3571726, DOI: 10.1016/j.jhep.2012.07.044.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell SurvivalCyclin-Dependent Kinase Inhibitor p21HepatocytesLiverMiceP38 Mitogen-Activated Protein KinasesPhosphorylationProto-Oncogene Proteins c-ablProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mdm2Proto-Oncogene Proteins c-metTranscription, GeneticTumor Suppressor Protein p53ConceptsHepatocyte survivalRT-PCR arrayHGF/METEmbryonic liverCell survivalP53 transcriptional responseP53 axisP53-dependent cell deathEmbryonic hepatocytesMdm2 upregulationAbstractTextPathway modulationLiverP53 pathwaySurvivalMetSSurvival propertiesTranscriptional responseSurvival genesDeathAIMSCell deathP53 phosphorylationPresent studyP38MAPK