2023
CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma
Geraldo L, Garcia C, Xu Y, Leser F, Grimaldi I, de Camargo Magalhães E, Dejaegher J, Solie L, Pereira C, Correia A, De Vleeschouwer S, Tavitian B, Canedo N, Mathivet T, Thomas J, Eichmann A, Lima F. CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma. Cellular And Molecular Life Sciences 2023, 80: 179. PMID: 37314567, PMCID: PMC10267017, DOI: 10.1007/s00018-023-04788-7.Peer-Reviewed Original ResearchConceptsMicroglia/macrophage recruitmentC chemokine receptor type 7CCL21-CCR7Central nervous systemMacrophage recruitmentTumor microenvironmentChemokine receptor type 7Fatal primary tumorMouse GBM modelsChemokine ligand 21Potential therapeutic targetVEGF-A productionTumor cell deathCCR7 expressionTherapeutic optionsPrimary tumorPoor survivalCurrent treatmentGBM patientsTumor cell migrationTherapeutic targetBrain cancerNervous systemChemotherapy resistanceLigand 21
1996
Endothelin-B receptor is expressed by neural crest cells in the avian embryo.
Nataf V, Lecoin L, Eichmann A, Le Douarin N. Endothelin-B receptor is expressed by neural crest cells in the avian embryo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9645-9650. PMID: 8790384, PMCID: PMC38482, DOI: 10.1073/pnas.93.18.9645.Peer-Reviewed Original ResearchConceptsNC cellsNC derivativesAvian embryosEnteric nervous system precursorsSpatiotemporal expression patternsNeural crest cellsEnteric nervous systemEndothelin B receptorGrowth-promoting pathwaysEndothelin-3NC developmentPluripotent stageNervous systemCrest cellsQuail homologueGene inactivationExpression patternsNeural crestNeural primordiumNeural tubeDevelopmental stagesEDNRB transcriptsEDNRB geneEmbryonic areaSmall population