Werner protein recruits DNA polymerase δ to the nucleolus
Szekely A, Chen Y, Zhang C, Oshima J, Weissman S. Werner protein recruits DNA polymerase δ to the nucleolus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 11365-11370. PMID: 11027336, PMCID: PMC17206, DOI: 10.1073/pnas.97.21.11365.Peer-Reviewed Original ResearchConceptsWerner proteinWRN proteinDNA replicationPolymerase deltaChromosomal DNA replicationTwo-hybrid screeningSubcellular localization studiesDNA polymerase δMajor DNA polymeraseDNA helicasesRecQ familyDNA transactionsDynamic relocalizationNucleolar proteinsCatalytic subunitPolymerase δC-terminusWRN geneWerner syndromeExonuclease activityPhysiological functionsMendelian disordersLocalization studiesLines of evidenceDNA polymerase