2020
Small-Molecule Antagonists of the RIG‑I Innate Immune Receptor
Rawling DC, Jagdmann GE, Potapova O, Pyle AM. Small-Molecule Antagonists of the RIG‑I Innate Immune Receptor. ACS Chemical Biology 2020, 15: 311-317. PMID: 31944652, DOI: 10.1021/acschembio.9b00810.Peer-Reviewed Original ResearchConceptsInnate immune systemRIG-I receptorRole of RIGSmall molecule antagonistsPotent RIGAutoimmune disordersAntimicrobial therapyRange of diseasesImmune systemInterferon responseVertebrate innate immune systemImmune receptorsReceptorsNew drug design strategiesAntagonistRNA virusesDrug design strategiesCOPD
1995
Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships.
Michels WJ, Pyle AM. Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: elucidation of reaction mechanism and structure/function relationships. Biochemistry 1995, 34: 2965-77. PMID: 7893710, DOI: 10.1021/bi00009a028.Peer-Reviewed Original Research