2020
Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS
Lucca LE, Lerner BA, Park C, DeBartolo D, Harnett B, Kumar VP, Ponath G, Raddassi K, Huttner A, Hafler DA, Pitt D. Differential expression of the T-cell inhibitor TIGIT in glioblastoma and MS. Neurology Neuroimmunology & Neuroinflammation 2020, 7: e712. PMID: 32269065, PMCID: PMC7188477, DOI: 10.1212/nxi.0000000000000712.Peer-Reviewed Original ResearchConceptsTumor-infiltrating T cellsT cellsPD-1/PD-L1Anti-TIGIT therapyExpression of CD226Expression of TIGITPostmortem CNS tissueLymphocytes of patientsFresh surgical resectionsLigand CD155TIGIT expressionSurgical resectionPD-1PD-L1CNS diseaseHealthy controlsHealthy donorsLymphocytic expressionImmune responseCNS tissueMS lesionsTIGITImmune pathwaysPatientsGlioblastoma multiforme
2012
Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36)
OConnor K, Fang L, Meizlish M, Anderson R, Bruce J, Huttner A, Lovato L. Meningiomas include an antigen-experienced B cell infiltrate that produces antibodies directed to tumor antigens (127.36). The Journal Of Immunology 2012, 188: 127.36-127.36. DOI: 10.4049/jimmunol.188.supp.127.36.Peer-Reviewed Original ResearchB-cell infiltratesCell infiltrateB cellsTumor antigensTumor-infiltrating B cellsAntigen-driven B cell responsesSpecific humoral immune responseCommon adult neoplasmImmune cell infiltratesB cell clonal expansionB cell responsesHumoral immune responseMemory B cellsCentral nervous systemCell clonal expansionB cell repertoireB cell maturationSignificant somatic mutationsDifferentiated plasma cellsImmune infiltratesAntigen experiencePlasma cellsImmune responseIntracranial tumorsCell repertoire