RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction
Yadav S, Garner K, Georgiev P, Li M, Gomez-Espinosa E, Panda A, Mathre S, Okkenhaug H, Cockcroft S, Raghu P. RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction. Journal Of Cell Science 2015, 128: 3330-3344. PMID: 26203165, PMCID: PMC4582195, DOI: 10.1242/jcs.173476.Peer-Reviewed Original ResearchConceptsPhospholipase CPlasma membraneEndoplasmic reticulumMulti-domain proteinsPlasma membrane lipidsExchange of lipidsRdgB functionDrosophila phototransductionDrosophila photoreceptorsProtein domainsRdgB mutantsVivo functionMembrane lipidsPtdInsLipid intermediatesLipid homeostasisMembrane receptorsPLC activationPtdOH levelsTransfer proteinPhosphatidic acidPLC activityPhototransductionNormal phototransductionPtdOH