Ania Jastreboff, MD, PhD
Cards
Professional Highlights
About
Research
Clinical Care
Professional Highlights
About
Research
Clinical Care
Professional Highlights
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Publications Overview
- 120 Publications
- 10,723 Citations
- 79 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight)
Co-Director, Yale Center for Weight Management
Medical Director, Yale Stress Center
Education
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
University of Maryland at Baltimore (2002)
Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Appointments
Publications Overview
- 120 Publications
- 10,723 Citations
- 79 Yale Co-Authors
Y-Weight: Yale Obesity Research Center
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileBoard Certification
2016
Clinical Specialties
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
Honors
- 8 National Awards
- 3 Yale School of Medicine Awards
- 1 Yale University Award
Activities
- 190 Activities
- 2006 - Present
- 18 Countries
Service
- 1 Committee
- 12 Professional Organizations
About
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Titles
Professor of Medicine (Endocrinology)
Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management; Medical Director, Yale Stress Center
Biography
Ania M. Jastreboff, MD, PhD is the Harvey and Kate Cushing Professor of Medicine and Professor of Pediatrics at Yale School of Medicine. Dr. Jastreboff is a physician-scientist, endocrinologist, and international thought leader in the scientific development and clinical application of novel anti-obesity pharmacotherapeutics revolutionizing obesity treatment. As founding director of the Yale Obesity Research Center (Y-Weight), she is leading and shaping pivotal landmark studies of dual- and triple-receptor hormone agonists and NIH-funded studies investigating the physiology of obesity. She has served as lead investigator and author for trials investigating novel nutrient-stimulated hormone (NuSH)-based therapies for obesity including dual hormone receptor agonist, tirzepatide, a GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022 and NEJM, 2024), triple hormone receptor agonist, retatrutide, a GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023), and a monthly monoclonal antibody peptide conjugate, maridebart cafraglutide, a GIP receptor antagonist GLP-1 receptor agonist (Jastreboff, et, al., NEJM, 2025). Trained in both adult endocrinology and pediatric endocrinology, and attaining board certification in five specialties (endocrinology, pediatric endocrinology, obesity medicine, internal medicine, and pediatrics), she has helped to develop Obesity Clinical Practice Guidelines, served on the Board of Governance for The Obesity Society (TOS), and as a director of the American Board of Obesity Medicine, and serves as co-director of the Yale Center for Weight Management, where she sees patients. She is a highly sought after speaker, teaching internationally, nationally, and locally. She is a compassionate advocate for patients with obesity, from grass-roots patient groups to interviews with Ms. Oprah Winfrey on CBS Sunday Morning, TODAY, and The View. She is also a New York Times Best-Selling author of Enough: Your Health, Your Weight, and What It’s Like to Be Free by Ania M. Jastreboff, MD, PhD and Oprah Winfrey.
Videos of Dr. Jastreboff speaking with Ms. Oprah Winfrey about obesity (YouTube podcast)
- Serena Williams and Oprah on GLP-1 Medications (posted Jan-13-2026)
- The Truth about Obesity (posted Jan-14-2025)
- How People Treat You After Weight Loss (posted Jan-21-2025)
- What Exactly is Obesity? (posted May-10-2024)
Video of Dr. Jastreboff speaking at the Lincoln Center about the biology of obesity and anti-obesity medications for the Yale For Humanity Illuminated event (NYC - January 2025)
Videos of Dr. Jastreboff and colleagues from the NEJM about:
- What causes obesity: https://www.nejm.org/doi/full/...
- Supporting patients with obesity: https://www.nejm.org/doi/full/...
- Medications and surgery for obesity treatment: https://www.nejm.org/doi/full/...
Yale video with Dr. Jastreboff about anti-obesity medications and the biology of obesity.
Clinically, Dr. Jastreboff specializes in sophisticated use of anti-obesity medication combinations to help patients reach their weight and health goals.
Recent misinformation has been circulating online regarding a so-called "pink salt trick" for weight loss. It is not medically supported, and it has no connection to Dr. Ania Jastreboff or Yale. Videos of Dr. Jastreboff purporting to endorse this product are fraudulent and have been AI generated.
Appointments
Endocrinology
ProfessorPrimary
Other Departments & Organizations
- All Institutions
- Center for Weight Management
- Center for Weight Management - NH & North Haven
- Diabetes Center
- Diabetes Program
- Diabetes Research Center
- Endocrinology
- Internal Medicine
- Obesity Research Working Group
- Pediatric Weight Solutions Program
- Status of Women in Medicine Committee (SWIM)
- Yale Medicine
- Yale New Haven Health System
- Yale Obesity Research Center (Y-Weight)
- Yale Stress Center
Education & Training
- Student - Yale Advanced Emerging Leaders
- Yale University (2023)
- Yale Public Voices Fellowship
- Yale University (2022)
- Clinical Scholar
- Yale University School of Medicine (2013)
- YCCI Clinical Research Scholar
- Yale School of Medicine (2013)
- PhD
- Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)
- Neuromanaging in Psychiatry
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Postdoctoral Fellowship
- Yale School of Medicine (2011)
- Food Policy and Science
- Yale University (2010)
- Learning to Mentor the next generation of scientists
- Yale School of Medicine (2009)
- Nutrition and Chronic Disease
- Yale University (2009)
- Chief Resident
- University of Maryland (2006)
- Residency
- University of Maryland School of Medicine (2006)
- Intern
- University of Maryland (2003)
- MD
- University of Maryland at Baltimore (2002)
- BA
- Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)
Research
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Overview
obesity; obesity pharmacotherapy
Medical Research Interests
Public Health Interests
ORCID
0000-0003-1446-0991Y-Weight: Yale Obesity Research Center
Investigating novel pharmacological therapeutics for obesity treatment and probing the mechanisms of obesity in translational physiology studies
View Lab Website
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Rajita Sinha, PhD
Yuan Lu, ScD
Harlan Krumholz, MD, SM
Wendy Silverman, PhD, ABPP
Michelle Van Name, MD
Alissa Chen, MD, MPH, MHS
Obesity
Weight Loss
Publications
2026
Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms
McKee S, Lydecker J, Pittman B, Jastreboff A, DiLeone R, Lavery M, Grilo C. Naltrexone/bupropion for binge-eating disorder: A human laboratory investigation of mechanisms. Drug And Alcohol Dependence Reports 2026, 19: 100428. PMID: 41867954, PMCID: PMC13000475, DOI: 10.1016/j.dadr.2026.100428.Peer-Reviewed Original ResearchAltmetricConceptsHuman laboratory studiesBinge-eating disorderRandomized clinical trialsBrain reward systemHunger ratingsHigh-caloric foodPlasma levelsPsychosocial impairmentEating episodesFood cravingsReward systemCravingEating behaviorsEarly treatment responseNaltrexone/bupropionPotential markersTreatment responseSweet snacksClinical trialsDisordersSecondary outcomesEffective treatmentInvestigation of mechanismsEffective therapeuticsSnack foodsMindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial.
Fogelman N, Bernstein H, Bautista T, Savoye M, Chaplin T, Silverman W, Jastreboff A, Sinha R. Mindfulness Intervention for Parent Stress and Childhood Obesity Risk: A Randomized Trial. 2026, 157 PMID: 41786283, PMCID: PMC12989181, DOI: 10.1542/peds.2025-072230.Peer-Reviewed Original ResearchAltmetricConceptsChildhood obesity riskEarly childhood obesity riskChildren's food intakeHealthy food intakeObesity riskParenting stressChild BMI z-scoreSignificant time main effectPositive parentingTime main effectsBMI z-scoreWeekly group interventionFood intakeAssessment of long-term effectsRandomized Controlled TrialsPhysical activityChild BMIGroup interventionHealthy nutritionSecondary outcomesMindfulness interventionEarly childhood risksCoprimary outcomesChildhood riskInterventionSemaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease
Nicholls S, Ryan D, Deanfield J, Ferreira D, Lang C, Lincoff A, Lingvay I, Lübker C, Terns P, Rasmussen S, Stensen S, Weeke P, Kahn S, Nibouche D, Chettibi M, Hammoudi N, Porto A, Oviedo A, Sanabria H, Casas M, Farias E, Duronto E, Chacon C, Villarino A, Farias J, Zaidman C, Morbey C, Colquhoun D, Ekinci E, Leung M, William M, Kostner K, Shirazi M, Cross D, Amerena J, Purnell P, Arstall M, Abhayaratna W, Toplak H, Prager R, Ludvik B, Kautzky-Willer A, Hanusch U, Aigner E, Kaser S, De Pauw M, Vanduynhoven P, Van De Borne P, Vercammen C, Verwerft J, Vrolix M, Turatti L, Saraiva J, Cercato C, Kormann A, Leite S, Rossi P, Arantes F, Maia L, Kaiser S, Fonseca A, Kurtz Lisboa H, Franco D, Nicolau J, Farsky P, Ritt L, Goudev A, Vassilev D, Runev N, Georgiev B, Katova T, Petrov I, Gelev V, Milanova M, Postadzhiyan A, Tokmakova M, Yotov Y, Tisheva-Gospodinova S, Minkova D, Prakova-Teneva Z, Vasileva S, Egan A, Tsoukas G, Verma S, Bourgeois R, Filteau P, Vijayaraghavan R, Hartleib M, Spaic T, Stewart J, Pandey A, Rabasa-Lhoret R, St-Maurice F, Cha J, Pedersen S, Allison R, Poirier P, Langlois M, Lau D, Robitaille Y, Weisnagel J, Constance C, Datta S, Garg N, Salter T, Vale N, Vallieres G, Peters K, Tellier G, Botero Lopez R, Urina Triana M, Cadena Bonfanti A, Accini Mendoza J, Rodriguez Plazas J, Martinez Cano C, Milicic D, Canecki Varzic S, Budincevic H, Delic-Brkljacic D, Ruzic A, Kruljac I, Fuckar K, Linhart A, Malecha J, Cermak O, Koleckar P, Klimsa Z, Kuchar L, Malicherova E, Stasek J, Haluzik M, Vesela A, Mæng M, Hove J, Egstrup K, Jensen S, Gislason G, Bôttcher M, Pietilä M, Ilveskoski E, Lakka T, Ahtiainen P, Ukkola O, Niskanen L, Keski-Opas T, Schiele F, Stephan D, Petit C, Kerneis M, Cariou B, Steg G, Verges B, Hulot J, Demicheli T, Thuan J, Barone Rochette G, Gatta-Cherifi B, Serusclat P, Al-Zoebi A, Appel K, Kreutzmann K, Chevts J, Denger R, Eggebrecht H, Von Engelhardt C, Hagenow A, Heymer P, Jacob S, Jungmair W, Kahrmann G, Kempe H, Von Münchhausen C, Lehrke M, Wagner J, Froer M, Sauter J, Meyhöfer S, Zeller H, Segner A, Stahl H, Steindorf J, Sturm K, Schaum T, Wendisch U, Liberopoulos E, Bargiota A, Tziomalos K, Lambadiari V, Pagkalos E, Kokkinos A, Argyrakopoulou G, Siasos G, Patsilinakos S, Lanaras L, Kartalis A, Ntaios G, Stamatelopoulos K, Tsougos E, Páll D, Kocsis G, Takács R, Baranyai M, Lupkovics G, Piros A, Könyves L, Kaul U, Mittal S, Jitendra Pal Singh S, Garg S, Ambuj R, Gandotra D, Thomas N, Kahali D, Abhaichand R, Christopher J, Hiremath S, Kannan J, Sethi R, Shah M, Ajay N, Prafulla K, Varghese K, Abhyankar A, Bhagwat A, Wander G, Chopra A, Parvathareddy K, Bansal S, Mahajan A, Pothineni R, Desai D, Vijan V, Agarwal D, Fulwani M, Arneja J, Desai P, Maher V, Molony D, Mcdonald K, Byrne M, O'shea D, Sreenan S, Le Roux C, Mosenzon O, Durst R, Bashkin A, Sofer Y, Vishlitzky V, Segal Lieberman G, Shechter M, Dicker D, Zornitzki T, Liberty I, Shehadeh N, Arbel Y, Buscemi S, Pagotto U, Vettor R, Santini F, Mingrone G, Dotta F, Cortinovis F, Cogni G, Bo S, Frittitta L, Malavazos A, Bucci M, Mannucci E, Sbraccia P, Colao A, Zatelli M, Muratori F, Leonetti F, Tuccinardi D, Mirani M, Berra C, Ohsugi M, Tanaka H, Onaka H, Watanabe A, Sugiura T, Morisaki K, Nagano T, Doi M, Natsuaki M, Miyamoto N, Fujii K, Oh F, Mitomo S, Kawanishi M, Kitamura R, Maeda H, Miyake T, Kinoshita N, Sato A, Takeuchi Y, Ueda O, Kiyosue A, Kodera S, Manita M, Fukushima Y, Kinoshita M, Yamasaki M, Sueyoshi A, Ando T, Hanaoka K, Isawa T, Hata Y, Kunishige H, Oguri M, Abe M, Matsumoto T, Ono Y, Okada Y, Kato T, Koga T, Fujita R, Sakamoto T, Okayama H, Kadokami T, Yamaguchi H, Iwasawa T, Maeda I, Teragawa H, Ezaki H, Lace A, Veze I, Rezgale I, Latkovskis G, Sime I, Teterovska D, Rancane G, Klavina I, Bang L, Ong T, Krishinan S, Lee L, Ali N, Ruhani A, Hussein Z, Rosman D, Abidin I, Wan Mohamed W, Kasim S, Morales Villegas E, García Reza R, Arenas León J, Lazcano Soto J, Bazzoni Ruiz A, Garcia Hernandez P, Jimenez-Ramos S, Arias Mendoza M, De Los Rios Ibarra M, Van Beek A, Schaap J, Swart H, Martens F, Nierop P, Vossenberg T, Van Der Zwaan C, Dorman R, Groenemeijer B, Römer T, Hjelmesaeth J, Tonstad S, Halvorsen S, Gullestad L, Gretland Valderhaug T, Høivik H, Høgalmen R, Nygård O, Rice E, Bogdanski P, Franek E, Gajos G, Ostrowska L, Szyprowska E, Lukaszewicz M, Kania G, Skoczylas G, Kujawiak M, Wozniak I, Chrustowski W, Jozefowska M, Leksycka A, Jurowiecki J, Czochra W, Pulka G, Karczmarczyk A, Stogowska-Nikiciuk B, Kalmucki P, Beckowski M, França S, Fonseca L, Martins C, Monteiro P, Pinto F, Hancu N, Vlad A, Pop L, Onaca A, Cif A, Kurtinecz M, Vladu I, Constantin C, Nafornita V, Toarba C, Constantinescu S, Avram R, Nicolescu G, Popa B, Cosma D, Marin L, Reurean Pintilei D, Morosanu M, Mîndrescu N, Mistodie C, Badiu C, Lupu S, Enculescu D, Caceaune E, Enache G, Gordeev I, Shaydyuk O, Kobalava Z, Khlevchuk T, Ezhov M, Mareev V, Vorobyeva O, Markova T, Ermakova P, Bolshakova O, Alpenidze D, Zrazhevskiy K, Sardinov R, Obrezan A, Zalevskaya A, Zagrebelnaya O, Dvoryashina I, Platonov D, Khaisheva L, Shutemova E, Sergeeva-Kondrachenko M, Smolenskaya O, Suplotova L, Shalaev S, Gilinskaya O, Barbarash O, Ryabov V, Boshchenko A, Samoilova Y, Veselovskaya N, Lysenko T, Zhdanova E, Zykov M, Belousova L, Peskov A, Ipatko I, Gurieva I, Ruyatkin D, Antonova E, Kazakova E, Ershova O, Vinogradova O, Guseva G, Pergaeva Y, Kharakhulakh M, Sorokin M, Krivosheeva I, Galyavich A, Sveklina T, Lalic N, Lalic K, Djenic N, Vukicevic M, Stokic E, Asanin M, Stankovic G, Ristic A, Ebrahim I, Urbach D, Corbett C, Lombard L, Badat A, Fulat M, Kapp C, Bandezi V, Moosa N, De Jong D, Tsabedze N, Van Der Walt E, Van Nieuwenhuizen E, Wadvalla S, Burgess L, Coetzee K, Dawood S, Peter J, Van Zyl L, Fourie N, Lombaard J, Makotoko E, Jugnundan P, Punt Z, Klug E, Tinahones F, De Pablo C, De La Cuesta C, Soto González A, Merino Torres J, Masmiquel Comas L, Rivas Fernández M, Castro A, Morales Portillo C, Mezquita Raya P, González Albarrán O, Rydén L, Eliasson B, Holmer H, Mooe T, Eliasson K, Lindholm C, Wu C, Hsieh I, Yeh H, Liu M, Lee T, Suwanwalaikorn S, Suwanagool A, Piyayotai D, Buranapin S, Vathesatogkit P, Udommongkol C, Sansanayudh N, Kiatchoosakun S, Wongcharoen W, Dagdelen S, Sonmez Y, Sancak S, Kayikcioglu M, Unubol M, Sari R, Bakiner O, Celik A, Altuntas Y, Gogas Yavuz D, Ozpelit E, Gul I, Ozdogan O, Yazici D, Araz M, Adas M, Tuna M, Soyluk Selcukbiricik O, Kanadasi M, Oguzhan A, Parkhomenko O, Lysak Z, Rudenko L, Velychko V, Levchenko O, Mostovoy Y, Stanislavchuk M, Kushnir M, Vyshnyvetskyy I, Ilashchuk T, Buriakovska O, Leonidova V, Kyyak Y, Horoshko O, Todoriuk L, Myshanych G, Wilding J, Andrews R, Asamoah N, Barber M, Bellary S, Broadley A, Capehorn M, Clark R, Clifford P, Stoker J, Creely S, Dang C, Dobson S, English P, Jackson-Voyzey E, Tatovic D, Keeling P, Khoo J, Lynch M, Lee K, Mcgowan B, Beerachee Y, Miras A, Myint M, Nair S, Paul N, Price H, Randeva H, Sathyapalan T, Senior R, Sharma R, Sharma S, Strzelecka A, Swanson N, Tait G, Vaidya B, Vincent R, Wakeling J, Wilson P, Wong Y, Wyatt N, Agaiby J, Al-Karadsheh A, Apovian C, Arif A, Aroda V, Shea H, Barnum O, Berk M, Pereira I, Biggs W, Billings L, Brautigam D, Brockmyre A, Budoff M, Buffman B, Burguera B, Busch R, Buse J, Call R, Cannon K, Curtis B, Chochinov R, Calinescu C, Clark W, Lewis M, Swenson B, Cornett G, Daboul N, Desouza C, Buljubasic N, Finneran M, Fordan S, Gandy J, Garvey W, Geller S, Geohas J, Gilbert M, Dukes C, Hartman A, Herman L, Houser P, Issa M, Jackson R, Jardula M, Jerkins T, Joyce J, Kastelic R, Nayak B, Kereiakes D, Klein E, Kubicki T, Ledesma G, Ruffin O, Lenzmeier T, Lepor N, Liu J, Lofton H, Lovell C, Marso S, Folkens E, Mclean B, Meyers P, Murthy A, Johnson W, Nakhle S, O'donnell P, Perkelvald A, Philis-Tsimikas A, Powell T, Pratley R, Purighalla R, Raikhel M, Rasouli N, Zacher J, Risser J, Correia M, Rosen G, Samal A, Sargeant W, Sathananthan A, Anderson R, Shlesinger Y, Poremba J, Siraj E, Sivalingam K, Smith S, Snyder B, Murray R, Sofley C, Still C, Oaks J, Warren M, Harris K, Wierum C, Wynne A, Saggar S, Chaicha-Brom T, Yuan Q, Klonoff D, Patel M, Singh N, Sultan S, Garza J, Morin R, Riley T, Shneker A, Jastreboff A, Wallace J, Condit J, Koren M, Munir I, Weber B, Jaffrani N, Hewitt E, Delibasic M, Lupovitch S, Davuluri A, Krishnasamy S, Ward K, Sotolongo C, Concha M, Ahmed A, Carr J, Heimer B, Zarich S, Morawski E, Potu R, Lorraine R, Agha M, Ariani M, Bakdash W, Bernstein M, Breton C, Dela Llana A, Opsahl P, Harris B, Iteld B, Abou Assi H, Logemann T, Siddiqui I, Ong S, Perez-Vargas E, Sangrigoli R, Wenocur H, Levy L, Mcpherson D, Block B, Gorton S, Qureshi M, Sigal F, Tripathy D, Brodie S, Vo A, Weintraub H, Wilson J, Aronne L, Audish H, Baum S, Beshay I, Herzog W, Jabbar D, Levins P, Miller G, Mills R, Oneil P, Pop-Busui R, Pullman J, Robbins D, Robertson D, Rodbard H, Solano R, Soufer J, Tamirisa A, Usdan L, Lash J, Doran J, Bosworth H, Iranmanesh A, Sidey J, Mcgrew F, Reyes C, Gambill M, D'agostino R, Welker J, Tran H, Kandath D, Bays H, Buynak R, Carrillo-Jimenez R, Martinez C, Bitar F, Ghazi A, Bhan A, Scott J, Serota H, Pereira E, Friedman K, Allison D, Chandra S, Trusau A, Shah N, Khadra S, Spriggs D. Semaglutide and Hospitalizations in Patients With Obesity and Established Cardiovascular Disease. JAMA Cardiology 2026, 11: 156-164. PMID: 41433034, PMCID: PMC12728728, DOI: 10.1001/jamacardio.2025.4824.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHospital admissionSerious adverse eventsRandomized clinical trialsEstablished CV diseaseCV diseaseSemaglutide groupRate of hospital admissionsAdverse eventsClinical trialsReduction of hospital admissionsDuration of hospital stayImpact of semaglutideBody mass indexTotal hospital admissionsEstablished cardiovascular diseaseEffect of semaglutideCV risk reductionOnce-weekly semaglutideAssociated with significant reductionsMain OutcomesMass indexPlacebo groupPatient yearsTotal hospitalHospital stayFDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/Obesity
Do D, Murugiah K, Sawano M, Cartwright B, Rodriguez P, Gratzl S, Curtis L, Jastreboff A, Lu Y, Stucky N. FDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/Obesity. JACC Advances 2026, 5: 102575. PMID: 41576595, PMCID: PMC12860981, DOI: 10.1016/j.jacadv.2025.102575.Peer-Reviewed Original ResearchConceptsTirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial
Malhotra A, Grunstein R, Azarbarzin A, Sands S, Somers V, Aronne L, Jastreboff A, Lou J, Chakladar S, Dunn J, Bunck M, Bednarik J. Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial. Nature Medicine 2026, 32: 653-659. PMID: 41540105, PMCID: PMC12920140, DOI: 10.1038/s41591-025-04071-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsObstructive sleep apnea metricsObstructive sleep apneaHomeostatic model assessmentModerate-to-severe OSAPlacebo-controlled phase 3 studyBlood pressureHigh-sensitivity C-reactive proteinModel assessmentInsulin resistanceApnea-hypopnea indexSleep-disordered breathingPhase 3 studyCardiometabolic risk factorsC-reactive proteinAssociated with obesityDiastolic blood pressureSystolic blood pressurePost Hoc AnalysisHypoxic burdenSleep apneaDouble-blindCardiometabolic riskCardiometabolic benefitsCardiovascular riskRandomized trials
2025
Once-Monthly Maridebart Cafraglutide in Obesity - A Phase 2 Trial. Reply.
Jastreboff A, Ryan D, Pannacciulli N. Once-Monthly Maridebart Cafraglutide in Obesity - A Phase 2 Trial. Reply. The New England Journal Of Medicine 2025, 393: 2275. PMID: 41337724, DOI: 10.1056/nejmc2514331.Peer-Reviewed Original ResearchAge-Specific Associations Between Adiposity and Mortality in U.S. Adults, 1999-2018
Lu Y, Mou Y, Liu Y, Chen A, Herrin J, Spatz E, Sharifi M, Jastreboff A, Krumholz H. Age-Specific Associations Between Adiposity and Mortality in U.S. Adults, 1999-2018. JACC Advances 2025, 4: 102234. PMID: 41205545, PMCID: PMC12639814, DOI: 10.1016/j.jacadv.2025.102234.Peer-Reviewed Original ResearchAltmetricConceptsU.S. adultsBody mass indexMortality HRAssociated with elevated all-cause mortalityNational Health and Nutrition Examination SurveyWaist-to-height ratioHealth and Nutrition Examination SurveyElevated all-cause mortalityMass indexYoung adultsNutrition Examination SurveySample of U.S. adultsAge-specific associationsClass 3 obesityAll-Cause MortalityCox proportional hazards modelsAge-tailored interventionAdiposity measuresExamination SurveyProportional hazards modelWaist circumferenceMortality dataAll-CauseUnderweight statusAnthropometric measurementsSemaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers
Kim C, Dinan M, Robinson T, Ross J, Jastreboff A, Krumholz H, Lu Y. Semaglutide and Tirzepatide Prescribing for Obesity in Patients With Preexisting Comorbid Cancers. JAMA Oncology 2025, 12: 101-104. PMID: 41196576, PMCID: PMC12593664, DOI: 10.1001/jamaoncol.2025.4560.Peer-Reviewed Original ResearchCitationsAltmetricCurrent and Future Medications for Obesity Treatment
Kushner R, Jastreboff A, Ryan D. Current and Future Medications for Obesity Treatment. JAMA: The Journal Of The American Medical Association 2025, 334: 1551-1552. PMID: 40932726, DOI: 10.1001/jama.2025.13665.Peer-Reviewed Original ResearchCitationsAltmetricClinical profile and long-term outcomes of chest pain patients with coronary microvascular dysfunction from the emergency department – results from the Yale-CMD registry
Safdar B, Zhou B, Li F, Camici P, Dziura J, Jastreboff A, Lansky A, Shah S, Sinusas A, Spatz E, D'Onofrio G. Clinical profile and long-term outcomes of chest pain patients with coronary microvascular dysfunction from the emergency department – results from the Yale-CMD registry. Microvascular Research 2025, 163: 104878. PMID: 41110546, DOI: 10.1016/j.mvr.2025.104878.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCMD patientsCoronary microvascular dysfunctionLong-term prognosisLong-term outcomesCoronary artery diseaseCoronary flow reserveEmergency departmentMicrovascular dysfunctionProspective cohortHeart failureHealthcare utilizationMedian follow-up timeHigh riskCohort of ED patientsMyocardial infarctionCardiac positron emission tomographyHigher adverse eventsChest pain patientsFollow-up timeAdverse cardiac eventsHigher MACE riskHigher healthcare utilizationAnnual follow-upSeattle Angina QuestionnaireProspective cohort of ED patients
Academic Achievements & Community Involvement
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Activities
activity Obesity - National Childhood Obesity Awareness Month Special Issue
06/01/2021 - PresentJournal ServiceAssociate Editoractivity Diabetes Care
2022 - PresentJournal ServiceAssociate Editoractivity The Obesity Society
2021 - PresentProfessional OrganizationsCo-ChairDetailsTOS Pediatric Obesity Treatment Task Forceactivity American Diabetes Association (ADA)
2008 - PresentProfessional OrganizationsMemberactivity American Association of Clinical Endocrinology (AACE) and American College of Endocrinology
2022 - PresentProfessional OrganizationsTask Force Member
Honors
honor New York Times Best-Selling Author
02/01/2026National Awardhonor Clinician of the Year Award, The Obesity Society
01/02/2023National AwardThe Obesity SocietyDetailsUnited Stateshonor American Board of Obesity Medicine (ABOM), Board of Directors (2022-2025)
05/01/2022National AwardABOMDetailsUnited Stateshonor Nominated for the Leonard Tow Humanism in Medicine Award Yale Teaching
01/01/2020Yale University AwardYale Universityhonor NIH/NIDDK K23 Mentored Patient-Oriented Research Career Development Award
05/01/2014National AwardDetailsUnited States
Clinical Care
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Overview
Ania M. Jastreboff, MD, PhD, is an adult and pediatric endocrinologist with expertise in obesity medicine and weight management. She cares for patients who have prediabetes, insulin resistance, metabolic syndrome, and type 1 and type 2 diabetes.
Dr. Jastrebroff, who is director of the Yale Obesity Research Center (Y-Weight), says she empathizes with patients who struggle to lose weight or maintain weight loss. “Carrying excess weight and having obesity is not a lifestyle choice. Obesity is a chronic disease and should be treated with the same vigor and integrity as other chronic diseases,” she says. “We are in the infancy of our understanding of the mechanisms that underlie obesity. Many novel treatments are under development, including new anti-obesity medications, endoscopic procedures, and the refining of behavioral and surgical interventions.”
An assistant professor of medicine (endocrinology) and of pediatrics (endocrinology) at Yale School of Medicine, Dr. Jastrebroff says one of her goals is to conduct clinic research that will lead to better treatments for obesity and also have a clear public health impact in mitigating the obesity “pandemic.”
Recent misinformation has been circulating online regarding a so-called "pink salt trick" for weight loss. It is not medically supported, and it has no connection to Dr. Ania Jastreboff or Yale. Videos of Dr. Jastreboff purporting to endorse this product are fraudulent and have been AI generated.
Clinical Specialties
Fact Sheets
Diabetes: Symptoms, Causes, and Treatments
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Board Certifications
Obesity Medicine
- Certification Organization
- AB of Obesity Medicine
- Original Certification Date
- 2016
Yale Medicine News
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View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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News
- March 27, 2026Source: Oprah Daily (with Dr. Ania Jastreboff)
"Triple G" Weight-Loss Meds Can Help Patients Shed 30 Percent of Their Body Weight-but Proceed With Caution
- March 08, 2026Source: Science Daily
Parents’ Stress May Be Quietly Driving Childhood Obesity, Yale Study Finds
- March 04, 2026Source: Yale News
‘Enough’ with Blame and Shame: The Science Behind Obesity and GLP-1s
- February 24, 2026
Stigma to Science: Yale’s Role in Changing Our Understanding of Obesity and Its Treatment
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.