2023
Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes
Zhang L, Bordey A. Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes. Biochimica Et Biophysica Acta (BBA) - Reviews On Cancer 2023, 1878: 188951. PMID: 37433417, DOI: 10.1016/j.bbcan.2023.188951.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsElectroporationGenetic EngineeringGliomaHumansImmune SystemTumor Microenvironment
1998
Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells
Bordey A, Sontheimer H. Electrophysiological Properties of Human Astrocytic Tumor Cells In Situ: Enigma of Spiking Glial Cells. Journal Of Neurophysiology 1998, 79: 2782-2793. PMID: 9582244, DOI: 10.1152/jn.1998.79.5.2782.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAstrocytesAstrocytomaBrain NeoplasmsCarcinomaCell DifferentiationChildChoroid Plexus NeoplasmsDelayed Rectifier Potassium ChannelsHumansIon TransportNeoplasm ProteinsNeoplastic Stem CellsNerve Tissue ProteinsPatch-Clamp TechniquesPotassiumPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingPotassium Channels, Voltage-GatedSodium Channel BlockersSodium ChannelsSpinal CordTetraethylammoniumTetrodotoxinConceptsAstrocytoma cellsTumor cellsGlial cellsWhole-cell patch-clamp recordingsCell patch-clamp recordingsAction potential-like responsesOlder pediatric patientsSpinal cord astrocytesHuman astrocytic tumor cellsSensitive sodium currentsGroup of tumorsLow-grade astrocytomasPatch-clamp recordingsOutward potassium currentGlial tumor cellsAstrocytic tumor cellsGeneration of spikesHigh input resistancePeritumoral astrocytesPediatric patientsMicroM Ba2Pilocytic astrocytomaPotassium currentAstrocytesElectrophysiological propertiesExpression of voltage-activated chloride currents in acute slices of human gliomas
Ullrich N, Bordey A, Gillespie GY, Sontheimer H. Expression of voltage-activated chloride currents in acute slices of human gliomas. Neuroscience 1998, 83: 1161-1173. PMID: 9502255, DOI: 10.1016/s0306-4522(97)00456-9.Peer-Reviewed Original ResearchConceptsAcute slicesChloride currentsGlioma cellsGrade tumorsGlial cellsPatient biopsiesWhole-cell patch-clamp recordingsChloride channelsHost glial cellsImplanted glioma cellsPathological tumor gradeLow-grade tumorsHigh-grade tumorsPatch-clamp recordingsSpecific Cl- channelsNormal glial cellsAstrocyte-like cellsShort-term cultureTumor gradePathological gradeSCID miceVoltage-activated sodiumIntracranial injectionPotassium currentExperimental tumors
1994
Mobilization of intracellular calcium by substance p in a human astrocytoma cell line (U‐373 MG)
Bordey A, Feltz P, Trouslard J. Mobilization of intracellular calcium by substance p in a human astrocytoma cell line (U‐373 MG). Glia 1994, 11: 277-283. PMID: 7525479, DOI: 10.1002/glia.440110309.Peer-Reviewed Original ResearchConceptsSubstance PReceptor agonistConcentrations of SPEffects of SPIntracellular free calcium concentrationSelective receptor agonistsNK1 receptor agonistNM substance PIntracellular calcium poolsFura-2 acetoxymethylesterHuman astrocytoma cell lineStable basal levelExtracellular calcium ionsFree calcium concentrationAstrocytoma cell linesHuman astrocytoma cellsPertussis treatmentNK1 receptorsIntracellular calciumCalcium poolMaximal effectCytosolic calciumAstrocytoma cellsBasal levelsCalcium concentration