Featured Publications
Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy
Nguyen LH, Xu Y, Mahadeo T, Zhang L, Lin TV, Born HA, Anderson AE, Bordey A. Expression of 4E-BP1 in juvenile mice alleviates mTOR-induced neuronal dysfunction and epilepsy. Brain 2021, 145: 1310-1325. PMID: 34849602, PMCID: PMC9128821, DOI: 10.1093/brain/awab390.Peer-Reviewed Original ResearchConceptsFocal malformationsCortical developmentJuvenile miceCortical spectral activitySpontaneous seizure frequencyIrregular firing patternNovel therapeutic opportunitiesNeuronal cytomegalySeizure frequencyEpilepsy onsetNeuronal abnormalitiesElectrophysiological alterationsIntractable epilepsyNeuronal dysfunctionJuvenile brainMouse modelMTOR pathwayTherapeutic opportunitiesMalformationsFiring patternsEpilepsyAberrant expressionNeurodevelopmental disordersMTOR effectorsMiceFilamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations
Zhang L, Huang T, Teaw S, Nguyen LH, Hsieh LS, Gong X, Burns LH, Bordey A. Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Science Translational Medicine 2020, 12 PMID: 32075941, DOI: 10.1126/scitranslmed.aay0289.Peer-Reviewed Original ResearchConceptsFocal cortical dysplasia type IITuberous sclerosis complexFocal cortical malformationsCortical malformationsSeizure frequencyReduced seizure frequencyVehicle-treated miceOnset of seizuresFilamin ALifelong epilepsyShort hairpin RNANeurological comorbiditiesNeuronal abnormalitiesSeizure activityEpilepsy treatmentSeizure onsetMouse modelAdult miceFLNA expressionPatientsCortical tissueMiceSeizuresMalformationsHairpin RNA
2021
CD-1 Outbred Mice Produce Less Variable Ultrasonic Vocalizations Than FVB Inbred Mice, While Displaying a Similar Developmental Trajectory
Binder MS, Shi HD, Bordey A. CD-1 Outbred Mice Produce Less Variable Ultrasonic Vocalizations Than FVB Inbred Mice, While Displaying a Similar Developmental Trajectory. Frontiers In Psychiatry 2021, 12: 687060. PMID: 34475829, PMCID: PMC8407076, DOI: 10.3389/fpsyt.2021.687060.Peer-Reviewed Original ResearchFVB miceOutbred miceCD-1Ultrasonic vocalizationsCD-1 micePostnatal day 4Female CD-1Neurological disorder modelsNeonatal ultrasonic vocalizationsNeurological deficitsNeonatal miceCD1 miceDay 4PD 12MicePD 4Maternal careLonger durationMean amplitudeSignificant differencesUSV productionOutbred animalsDevelopmental trajectoriesMore ultrasonic vocalizationsFVB
2016
Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks
Hsieh LS, Wen JH, Miyares L, Lombroso PJ, Bordey A. Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks. Neuroscience Letters 2016, 637: 142-147. PMID: 27871995, PMCID: PMC5203811, DOI: 10.1016/j.neulet.2016.11.035.Peer-Reviewed Original ResearchConceptsOutbred CD1 miceC57 miceCD1 miceAge-matched male miceThree-chamber sociability testThree-chamber testThree-chamber taskStranger mouseSocial interaction testAggressive behaviorMale CD1C57BL/6J miceMale miceBehavioral testingSociability testOutbred miceMiceMouse strainsStatistical significanceInteraction testMore timeTsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels
Zhang L, Huang T, Bordey A. Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neuroscience Letters 2016, 629: 15-18. PMID: 27345385, PMCID: PMC4983256, DOI: 10.1016/j.neulet.2016.06.037.Peer-Reviewed Original ResearchConceptsTuberous sclerosis complexDendritic complexityDendritic patterningTotal dendritic lengthTsc1 haploinsufficiencyFLNA levelsNeonatal electroporationDendritic lengthNewborn neuronsDendritic abnormalitiesSholl analysisOlfactory bulbFilamin ATsc1 lossHeterozygote miceCognitive defectsDendritic morphologyMiceA levelsMost individualsHaploinsufficiencyHeterozygote conditionLevelsAbnormalitiesNeuronsSwitching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice
Mahoney C, Feliciano DM, Bordey A, Hartman NW. Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neuroscience Letters 2016, 614: 112-118. PMID: 26812181, DOI: 10.1016/j.neulet.2015.12.042.Peer-Reviewed Original ResearchConceptsNeural stem cellsSubventricular zoneNeonatal subventricular zoneWeek old miceTuberous sclerosis complexStem cellsNewborn neuroblastsYoung miceOld miceProgressive lossYoung adultsRapamycin complex 1Mechanistic targetRecent evidenceProliferative cellsMiceHyperactive mTORC1Terminal differentiationCellsMTORC1 activationProliferationActivationMTORC1NeurogenesisHyperactivity
2010
Imaging and Recording Subventricular Zone Progenitor Cells in Live Tissue of Postnatal Mice
Lacar B, Young SZ, Platel JC, Bordey A. Imaging and Recording Subventricular Zone Progenitor Cells in Live Tissue of Postnatal Mice. Frontiers In Neuroscience 2010, 4: 43. PMID: 20700392, PMCID: PMC2918349, DOI: 10.3389/fnins.2010.00043.Peer-Reviewed Original ResearchSubventricular zoneSVZ cellsSubventricular zone progenitor cellsPatch-clamp recordingsCell populationsAstrocyte-like cellsFluorescent reporter miceRNA interference technologyNeurogenic zonesAcute slicesCellular diversityGlial cellsLateral ventricleMultiple cell populationsOlfactory bulbPostnatal brainClamp recordingsReporter miceFloxed miceTransgenic micePostnatal miceCalcium activityMiceProgenitor cellsGenetic labeling