2024
mTOR in Acquired and Genetic Models of Epilepsy
Wong M, Bordey A, Danzer S. mTOR in Acquired and Genetic Models of Epilepsy. 2024, 45-74. DOI: 10.1093/med/9780197549469.003.0004.Peer-Reviewed Original ResearchDisrupted mTOR signalingMTOR signalingDysregulation of mTOR signalingCellular functionsMTOR pathway signalingAbstract MutationsTarget of rapamycinPathway signalingSignaling pathwayGenetic modelsMTOR pathwayPathway disruptionMTORPathwayNongenetic causesRegulate brain developmentGeneral patternTraumatic brain injuryTuberous sclerosis complexGenetic model of epilepsyPatterns of brain pathologyPotential mechanismsSignalBrain developmentModulator of epileptogenesis
2021
Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex
Zhang L, Zhang X, Hsieh LS, Lin TV, Bordey A. Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex. Cells 2021, 10: 622. PMID: 33799820, PMCID: PMC8000154, DOI: 10.3390/cells10030622.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritic SpinesExcitatory Postsynaptic PotentialsExtracellular VesiclesFemaleGene Expression Regulation, DevelopmentalGestational AgeMiceParacrine CommunicationPregnancyPyramidal CellsRab27 GTP-Binding ProteinsSensory Receptor CellsSomatosensory CortexSynaptic TransmissionVibrissaeConceptsSmall extracellular vesiclesL4 neuronsParacrine communicationExcitatory synaptic transmissionRelease of sEVsDendritic spine formationCell-autonomous effectsRisk of autismL2/3 neuronsPyramidal neuronsLayer 2/3Somatosensory cortexBarrel cortexCortical neuronsSynaptic transmissionWhisker stimulationSomatosensory informationJuvenile miceSynaptic connectivitySynaptic integrationSpine formationBrain developmentNeuronsSensory stimulationSpine development
2014
Embryonic Cerebrospinal Fluid Nanovesicles Carry Evolutionarily Conserved Molecules and Promote Neural Stem Cell Amplification
Feliciano DM, Zhang S, Nasrallah CM, Lisgo SN, Bordey A. Embryonic Cerebrospinal Fluid Nanovesicles Carry Evolutionarily Conserved Molecules and Promote Neural Stem Cell Amplification. PLOS ONE 2014, 9: e88810. PMID: 24533152, PMCID: PMC3923048, DOI: 10.1371/journal.pone.0088810.Peer-Reviewed Original ResearchConceptsNeural stem cellsRapamycin complex 1 (mTORC1) pathwayIntracellular pathwaysStem cell amplificationInsulin-like growth factorCoordinated regulationGenetic programMicroRNA componentsExosome NanovesiclesEmbryonic CSFCell amplificationStem cellsENSCsPathwayCoordinated transferGrowth factorHuman embryosBrain developmentNanovesiclesMixed cultureAmplificationMoleculesEmbryosProteinExosomes
2012
Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!
Ben-Ari Y, Woodin MA, Sernagor E, Cancedda L, Vinay L, Rivera C, Legendre P, Luhmann HJ, Bordey A, Wenner P, Fukuda A, van den Pol AN, Gaiarsa JL, Cherubini E. Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever! Frontiers In Cellular Neuroscience 2012, 6: 35. PMID: 22973192, PMCID: PMC3428604, DOI: 10.3389/fncel.2012.00035.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2008
GABAA receptors, anesthetics and anticonvulsants in brain development.
Henschel O, Gipson KE, Bordey A. GABAA receptors, anesthetics and anticonvulsants in brain development. CNS & Neurological Disorders - Drug Targets 2008, 7: 211-24. PMID: 18537647, PMCID: PMC2557552, DOI: 10.2174/187152708784083812.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGABAergic drugsBrain developmentLong-term cognitive deficitsMain inhibitory neurotransmitterFunction of GABANeonatal periodInhibitory neurotransmitterGABAA receptorsMature brainNeuronal excitabilitySide effectsCognitive deficitsClinical perspectiveGABACNS developmentReceptorsReceptor propertiesDrugsAnticonvulsantsAnestheticsBasic scienceReviewSedativesExcitabilityNeurotransmitters