2023
Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction tests
2018
GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21
Wiemels JL, Walsh KM, de Smith AJ, Metayer C, Gonseth S, Hansen HM, Francis SS, Ojha J, Smirnov I, Barcellos L, Xiao X, Morimoto L, McKean-Cowdin R, Wang R, Yu H, Hoh J, DeWan AT, Ma X. GWAS in childhood acute lymphoblastic leukemia reveals novel genetic associations at chromosomes 17q12 and 8q24.21. Nature Communications 2018, 9: 286. PMID: 29348612, PMCID: PMC5773513, DOI: 10.1038/s41467-017-02596-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaliforniaChild, PreschoolChromosomes, Human, Pair 17Chromosomes, Human, Pair 8FemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHispanic or LatinoHumansInfantInfant, NewbornMalePolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaRisk FactorsConceptsNew risk lociRisk lociGenome-wide association studiesGrowth regulation pathwaysGenetic associationAcute lymphoblastic leukemiaNovel genetic associationsChildhood acute lymphoblastic leukemiaGenetic Epidemiology ResearchTranscription factorsStrong genetic associationGene expressionAssociation studiesLymphocyte developmentMYC oncogeneChromosome 17q12Oncology GroupLymphoblastic leukemiaLociChildren's Oncology GroupCalifornia Childhood Leukemia StudyChildhood Leukemia StudyStructural contactsYear of birthNon-Latino whites
2012
Whole-exome sequencing of a pedigree segregating asthma
DeWan AT, Egan KB, Hellenbrand K, Sorrentino K, Pizzoferrato N, Walsh KM, Bracken MB. Whole-exome sequencing of a pedigree segregating asthma. BMC Medical Genomics 2012, 13: 95. PMID: 23046476, PMCID: PMC3563469, DOI: 10.1186/1471-2350-13-95.Peer-Reviewed Original ResearchConceptsNon-asthmatic childrenWhole-exome sequencingAsthma candidate genesAsthmatic childrenAsthmaAsthma associationsAffected motherExome sequencingUnaffected fatherAsthma-susceptibility variantsPrediction scoreUnaffected offspringCommon risk variantsRisk variantsCandidate genesChildrenNonsynonymous variantsAffected offspring