Andre Levchenko
John C. Malone Professor of Biomedical EngineeringDownloadHi-Res Photo
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Appointments
Neurosurgery
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About
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Titles
John C. Malone Professor of Biomedical Engineering
Appointments
Neurosurgery
ProfessorSecondary
Other Departments & Organizations
- Cancer Signaling Networks
- Immunology
- Neurosurgery
- Program in Neurodevelopment and Regeneration
- Yale Biomedical Imaging Institute
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale CTAP
- Yale Fibrosis Program
- Yale-BI Biomedical Data Science Fellowship
- YCCEH
Research
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Overview
Medical Research Interests
Cell Communication; Microfluidics; Signal Transduction; Systems Biology
ORCID
0000-0001-6262-1222
Research at a Glance
Yale Co-Authors
Frequent collaborators of Andre Levchenko's published research.
Publications Timeline
A big-picture view of Andre Levchenko's research output by year.
Research Interests
Research topics Andre Levchenko is interested in exploring.
Michael Murrell
Sung Hoon Lee
Sidi Chen, PhD
Alexandre Jourdon, PhD
Alexej Abyzov, PhD
Anjelica Gonzalez, PhD
53Publications
4,685Citations
Signal Transduction
Cell Communication
Systems Biology
Publications
2026
SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma
Tang H, Sailo B, Shang X, Hossan M, Kratz J, Das P, Chhoda A, Aldo P, Liu H, Robert M, Doucette S, Paris T, Kunstman J, Pappou E, Wood L, Iacobuzio-Donahue C, Wolfgang C, He L, Pfaff M, Ang-Olson O, Hoggard T, Garcia-Milian R, Sharma A, Levchenko A, Ahuja N. SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma. Cell Reports 2026, 45: 117806. PMID: 42611708, DOI: 10.1016/j.celrep.2026.117806.Peer-Reviewed Original ResearchAltmetricAssessing the reliability of cellular decision making from noisy, multidimensional single-cell TNF–NF-κB signaling data
Emadi A, Lipniacki T, Levchenko A, Abdi A. Assessing the reliability of cellular decision making from noisy, multidimensional single-cell TNF–NF-κB signaling data. PLOS Computational Biology 2026, 22: e1014608. PMID: 42585223, PMCID: PMC13552947, DOI: 10.1371/journal.pcbi.1014608.Peer-Reviewed Original ResearchAltmetricThe root cause: why do so many drugs fail to translate from bench to bedside?
Levchenko A, Corrigan M, Wexler B. The root cause: why do so many drugs fail to translate from bench to bedside? Expert Opinion On Drug Discovery 2026, 21: 823-826. PMID: 42021580, DOI: 10.1080/17460441.2026.2665217.Commentaries, Editorials and LettersCitationsCancer signaling beyond the genes
Levchenko A, Madsen R. Cancer signaling beyond the genes. Current Opinion In Cell Biology 2026, 100: 102643. PMID: 42000563, DOI: 10.1016/j.ceb.2026.102643.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsDisruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states
Torborg S, Kim J, Singhal A, Grbovic-Huezo O, Holm M, Wu K, Han X, Ho Y, Haglund C, Mitchell M, Lowe S, Dow L, Pitter K, Sanchez-Rivera F, Levchenko A, Tammela T. Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Developmental Cell 2026, 61: 1012-1027.e8. PMID: 41875882, PMCID: PMC13179057, DOI: 10.1016/j.devcel.2026.02.017.Peer-Reviewed Original ResearchCitationsAltmetricCRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1
Maeda M, Sherman K, Zhou W, Cheng J, Nihongaki Y, Idrizi A, Tryggvadottir R, Camacho O, Shang X, Min J, Koldobskiy M, Maitra A, Levchenko A, Slusher B, Ji H, Feinberg A. CRISPR screen of human pancreatic cancer xenografts identifies a KLF5 proliferation vulnerability through epigenetic modifiers NCAPD2 and MTHFD1. Molecular Cancer 2026, 25: 75. PMID: 41668133, PMCID: PMC12998327, DOI: 10.1186/s12943-026-02575-z.Peer-Reviewed Original ResearchCitationsAltmetricThe hierarchical timescale hypothesis: Functional and structural convergence of biological networks and artificial neural nets
Lee S, Nemenman I, Levchenko A. The hierarchical timescale hypothesis: Functional and structural convergence of biological networks and artificial neural nets. Cell Systems 2026, 17: 101507. PMID: 41713403, DOI: 10.1016/j.cels.2025.101507.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThis study investigates the hierarchical timescale hypothesis, showing biological and artificial networks optimize signal processing by layering responses across progressively slower timescales to handle complex inputs.
2025
Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway
Lee S, Kang T, Shang X, Levchenko A. Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway. Cell Systems 2025, 16: 101321. PMID: 40541183, PMCID: PMC12276906, DOI: 10.1016/j.cels.2025.101321.Peer-Reviewed Original ResearchCitationsAltmetricYAP controls cell migration and invasion through a Rho GTPase switch
Shah S, Ren C, Tippens N, Park J, Mohyeldin A, Wang S, Vela G, Martinez-Gutierrez J, Margolis S, Schmidt S, Xia S, Quiñones-Hinojosa A, Levchenko A. YAP controls cell migration and invasion through a Rho GTPase switch. Science Signaling 2025, 18: eadu3794-eadu3794. PMID: 40424361, PMCID: PMC12268267, DOI: 10.1126/scisignal.adu3794.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBrain NeoplasmsCell Line, TumorCell MovementFemaleGlioblastomaGuanine Nucleotide Exchange FactorsHumansMiceNeoplasm InvasivenessPhosphoproteinsProtein Serine-Threonine Kinasesrac1 GTP-Binding ProteinrhoA GTP-Binding ProteinSignal TransductionSTAT3 Transcription FactorTranscription FactorsYAP-Signaling ProteinsSpecification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines
Scuderi S, Kang T, Jourdon A, Nelson A, Yang L, Wu F, Anderson G, Mariani J, Tomasini L, Sarangi V, Abyzov A, Levchenko A, Vaccarino F. Specification of human brain regions with orthogonal gradients of WNT and SHH in organoids reveals patterning variations across cell lines. Cell Stem Cell 2025, 32: 970-989.e11. PMID: 40315847, PMCID: PMC12145255, DOI: 10.1016/j.stem.2025.04.006.Peer-Reviewed Original ResearchCitationsAltmetric
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News
- May 01, 2025Source: Yale News
How Molecular Traffic Cops Guide Development of the Human Brain
- July 27, 2023
Yale Scientists Develop a New Approach to Strengthen CAR-T Cell Therapy for Cancer Treatment
- April 04, 2023Source: Yale Daily News
Researchers explore the role of cellular plasticity in cancer
- February 23, 2023Source: Big Think
Cancer evolution is mathematical
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