2015
The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity
Tubman VN, Mejia P, Shmukler BE, Bei AK, Alper SL, Mitchell JR, Brugnara C, Duraisingh MT. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrobial Agents And Chemotherapy 2015, 60: 613-616. PMID: 26459896, PMCID: PMC4704178, DOI: 10.1128/aac.01668-15.Peer-Reviewed Original ResearchConceptsGardos channel inhibitorChannel inhibitorsSickle cell diseaseC57BL/6 miceClinical trialsCell diseaseAntimalarial developmentPlasmodium growthErythrocyte dehydrationGardos channelSenicapocBlood stagesBiochemical profileAntimalarial activityPrimate plasmodiaVitro growthInhibitorsPatientsParasitemiaBlockadeDiseaseMiceTrials
2013
Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans
Lim C, Hansen E, DeSimone TM, Moreno Y, Junker K, Bei A, Brugnara C, Buckee CO, Duraisingh MT. Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans. Nature Communications 2013, 4: 1638. PMID: 23535659, PMCID: PMC3762474, DOI: 10.1038/ncomms2612.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsErythrocytesHumansMacaca mulattaPlasmodium knowlesiZoonosesConceptsRed blood cellsParasite densityP. knowlesiHuman bloodPlasmodium falciparum infectionMalaria parasite Plasmodium knowlesiYoung red blood cellsZoonotic malaria parasiteHigh parasite densityOld red blood cellsFalciparum infectionClinical infectionSevere diseaseWide age rangeNormal human bloodPlasmodium knowlesiMalaria parasitesBlood cellsImportant zoonosisAge rangeInfectionBloodKnowlesiYoung cellsCulture system