2024
The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition
Magrou L, Joyce M, Froudist-Walsh S, Datta D, Wang X, Martinez-Trujillo J, Arnsten A. The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition. Cerebral Cortex 2024, 34: bhae174. PMID: 38771244, PMCID: PMC11107384, DOI: 10.1093/cercor/bhae174.Peer-Reviewed Original ResearchConceptsInter-areal connectionsVisual cortexPrimary visual cortexHigher cortical areasMacaque cortexPrimate specializationHigher cognitionPrimate cortexV1Working memory storageDendritic spine densityTop-down regulationPrefrontal cortexConnection structureSpine densityFunctional segregationCortical areasFrontal areasCortexConnectomeNetwork organizationMemory storageMultimodal association
2015
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten AF. Stress weakens prefrontal networks: molecular insults to higher cognition. Nature Neuroscience 2015, 18: 1376-1385. PMID: 26404712, PMCID: PMC4816215, DOI: 10.1038/nn.4087.Peer-Reviewed Original Research
2010
Dynamic Network Connectivity: A new form of neuroplasticity
Arnsten AF, Paspalas CD, Gamo NJ, Yang Y, Wang M. Dynamic Network Connectivity: A new form of neuroplasticity. Trends In Cognitive Sciences 2010, 14: 365-375. PMID: 20554470, PMCID: PMC2914830, DOI: 10.1016/j.tics.2010.05.003.Peer-Reviewed Original Research
2009
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten AF. Stress signalling pathways that impair prefrontal cortex structure and function. Nature Reviews Neuroscience 2009, 10: 410-422. PMID: 19455173, PMCID: PMC2907136, DOI: 10.1038/nrn2648.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain ChemistryHumansNerve NetNeural PathwaysPrefrontal CortexSignal TransductionStress, PsychologicalConceptsPrefrontal functionMemory abilityUncontrollable stressPrefrontal cortex structurePrefrontal pyramidal cellsControl of behaviorCognitive abilitiesEmotional operationsPrefrontal networkImpair performanceMental illnessPrefrontal dysfunctionPrefrontal cortexPrefrontal gray matterPrefrontal neuronsMemory functionStress impairsPersistent firingNeurochemical environmentStress exposureNeurochemical eventsCortex structureHigh levelsEmotionsChronic stress
1997
Catecholamine regulation of the prefrontal cortex
Arnsten A. Catecholamine regulation of the prefrontal cortex. Journal Of Psychopharmacology 1997, 11: 151-162. PMID: 9208378, DOI: 10.1177/026988119701100208.Peer-Reviewed Original ResearchConceptsPrefrontal cortexAdrenergic receptorsAlpha-1 adrenergic receptorsPFC functionPFC cognitive functionAlpha 2A-adrenergic receptorD1 receptor stimulationTreatment of disordersCatecholamine regulationCatecholamine releaseDA stimulationCatecholamine stimulationD2 familyProminent symptomReceptor stimulationModulatory influencePFC dysfunctionCognitive functionSubcortical structuresReview evidenceDetrimental actionsCatecholamines dopamineReceptorsStimulationNorepinephrine
1985
Catecholamines and Cognitive Decline in Aged Nonhuman Primates
ARNSTEN A, GOLDMAN‐RAKIC P. Catecholamines and Cognitive Decline in Aged Nonhuman Primates. Annals Of The New York Academy Of Sciences 1985, 444: 218-234. PMID: 3925850, DOI: 10.1111/j.1749-6632.1985.tb37592.x.Peer-Reviewed Original Research
1984
Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey
Arnsten A, Goldman-Rakic PS. Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey. Brain Research 1984, 306: 9-18. PMID: 6466989, DOI: 10.1016/0006-8993(84)90351-2.Peer-Reviewed Original ResearchConceptsRaphe nucleusLocus coeruleusDorsal prefrontal cortexInferior temporal gyrusCortical areasPrefrontal cortexCortical projectionsRhesus monkeysTemporal gyrusAnterograde labeling techniquesCentral superior raphe nucleiPrefrontal cortical projectionsNoradrenergic locus coeruleusContralateral locus coeruleusParietal association cortexSuperior raphe nucleusDorsolateral prefrontal cortexSerotonergic dorsalLabeled fibersCerebral cortexCortical injectionsOrbital prefrontal cortexMonoaminergic innervationRaphe regionSomatosensory cortex